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    Method for acquiring information of a biochip using time of flight secondary ion mass spectrometry and an apparatus for acquiring information for the application thereof
    5.
    发明授权
    Method for acquiring information of a biochip using time of flight secondary ion mass spectrometry and an apparatus for acquiring information for the application thereof 有权
    使用飞行时间二次离子质谱法获取生物芯片的信息的方法和用于获取其应用信息的装置

    公开(公告)号：US07188031B1

    公开(公告)日：2007-03-06

    申请号：US10601777

    申请日：2003-06-24

    申请人： Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

    发明人： Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

    IPC分类号： G01N33/48 ,  G01R23/02 ,  C12Q1/00 ,  C12M1/34

    CPC分类号： G01N23/2258 ,  H01J49/16 ,  H01J49/40

    摘要： A measurement method is provided, which enables to obtain a two-dimensional image with better quantitative-ability by suppressing the influence of the charge-up, when the two-dimensional secondary ion image is obtained for a biological material fixed on a substrate having a high resistivity by utilizing a TOF-SIMS method in a certain wide area. A two-dimensional image having considerably high positioning resolution-ability can be obtained by the procedure in which the pulsed primary ion beam is irradiated at a spot, and the pulse-wise spot-applications of the primary ion beam and the simultaneous detection of the secondary ion generated from the irradiated primary ion beam proceed along with a discontinuous scanning pattern, and eventually the results of these secondary ion measurements are reconstructed into a two-dimensional image in line with the aforementioned discontinuous scanning pattern.

    摘要翻译： 提供了一种测量方法，其能够通过抑制电荷的影响来获得具有更好的定量能力的二维图像，当获得固定在具有 在某一广泛领域利用TOF-SIMS方法具有高电阻率。 具有相当高的定位分辨能力的二维图像可以通过脉冲一次离子束在一个点照射的过程和一次离子束的脉冲点应用和同时检测 从照射的一次离子束产生的二次离子与不连续扫描图案一起进行，最终将这些二次离子测量的结果重建为与上述不连续扫描图案一致的二维图像。

    METHOD FOR ACQUIRING INFORMATION OF A BIOCHIP USING TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY AND AN APPARATUS FOR ACQUIRING INFORMATION FOR THE APPLICATION THEREOF
    6.
    发明申请
    METHOD FOR ACQUIRING INFORMATION OF A BIOCHIP USING TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY AND AN APPARATUS FOR ACQUIRING INFORMATION FOR THE APPLICATION THEREOF 有权
    使用飞行次级离子质谱的时间获取生物信息的方法和获取其应用信息的装置

    公开(公告)号：US20070042496A1

    公开(公告)日：2007-02-22

    申请号：US10601777

    申请日：2003-06-24

    申请人： Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

    发明人： Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

    IPC分类号： G06F19/00 ,  G01N33/50

    CPC分类号： G01N23/2258 ,  H01J49/16 ,  H01J49/40

    摘要： A measurement method is provided, which enables to obtain a two-dimensional image with better quantitative-ability by suppressing the influence of the charge-up, when the two-dimensional secondary ion image is obtained for a biological material fixed on a substrate having a high resistivity by utilizing a TOF-SIMS method in a certain wide area. A two-dimensional image having considerably high positioning resolution-ability can be obtained by the procedure in which the pulsed primary ion beam is irradiated at a spot, and the pulse-wise spot-applications of the primary ion beam and the simultaneous detection of the secondary ion generated from the irradiated primary ion beam proceed along with a discontinuous scanning pattern, and eventually the results of these secondary ion measurements are reconstructed into a two-dimensional image in line with the aforementioned discontinuous scanning pattern.

    摘要翻译： 提供了一种测量方法，其能够通过抑制电荷的影响来获得具有更好的定量能力的二维图像，当获得固定在具有 在某一广泛领域利用TOF-SIMS方法具有高电阻率。 具有相当高的定位分辨能力的二维图像可以通过脉冲一次离子束在一个点照射的过程和一次离子束的脉冲点应用和同时检测 从照射的一次离子束产生的二次离子与不连续扫描图案一起进行，最终将这些二次离子测量的结果重建为与上述不连续扫描图案一致的二维图像。

    DNA MICRO-ARRAY HAVING STANDARD PROBE AND KIT INCLUDING THE ARRAY
    7.
    发明申请
    DNA MICRO-ARRAY HAVING STANDARD PROBE AND KIT INCLUDING THE ARRAY 审中-公开
    具有标准探针和包装阵列的DNA微阵列

    公开(公告)号：US20090093373A1

    公开(公告)日：2009-04-09

    申请号：US12264241

    申请日：2008-11-03

    申请人： Masahiro Kawaguchi ,  Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

    发明人： Masahiro Kawaguchi ,  Tadashi Okamoto ,  Hiromitsu Takase ,  Hiroyuki Hashimoto

    IPC分类号： C40B30/04 ,  C40B30/10

    CPC分类号： C12Q1/6837

    摘要： To provide a DNA micro-array having a nucleic acid probe immobilized on a substrate, which is used to detect a molecule of a target nucleic acid contained in a sample and has a substantially complementary base sequence to the target base sequence of the nucleic acid molecule, including at least one probe selected from the group consisting of: at least one internal standard probe for assay of PCR of the target nucleic acid; at least one external standard probe for a detection operation and assay of an amount of the probe; and a probe for measurement of the amount or density of the nucleic acid probe, formed by the same method as the nucleic acid probe.

    摘要翻译： 提供具有固定在底物上的核酸探针的DNA微阵列，其用于检测样品中所含的靶核酸的分子，并且与核酸分子的靶碱基序列具有基本上互补的碱基序列 包括至少一种选自以下的探针：用于测定靶核酸的PCR的至少一个内标物探针; 用于检测操作的至少一个外部标准探针和探针的量的测定; 以及通过与核酸探针相同的方法形成的用于测量核酸探针的量或密度的探针。