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17 条记录 (耗时 0.047 秒)

    Endothelin antagonists
    4.
    发明授权
    Endothelin antagonists 失效
    内皮素拮抗剂

    公开(公告)号：US06207686B1

    公开(公告)日：2001-03-27

    申请号：US08836198

    申请日：1997-06-20

    申请人： Masahiro Neya ,  Tatsuya Zenkoh ,  Hitoshi Sawada ,  Chiyoshi Kasahara ,  Masayoshi Murata ,  Keiji Hemmi

    发明人： Masahiro Neya ,  Tatsuya Zenkoh ,  Hitoshi Sawada ,  Chiyoshi Kasahara ,  Masayoshi Murata ,  Keiji Hemmi

    IPC分类号： A61K3138

    CPC分类号： C07D405/12 ,  C07D209/20 ,  C07D317/60 ,  C07D409/12

    摘要： A compound of formula (I), in which: R1 is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2 is hydrogen, hydroxy or protected hydroxy; R3 is lower alkyl, aryl, ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl; R4 is carboxy, protected carboxy or lower alkylsufonylcarbamoyl; R5 is hydrogen or lower alkyl; R6 is hydrogen or heterocyclic group; A is a single bond or lower alkylene, and Ar is optionally substituted aryl, or pharmaceutically acceptable salts thereof, having endothelin antagonistic activity.

    摘要翻译： 式（I）化合物，其中：R 1为低级烷基，环（低级）烷基，任选取代的芳基，任选取代的杂环基，环（低级）烷基（低级）烷基或芳（低级）烷基; R2是氢，羟基或被保护的羟基; R3是低级烷基，芳基，芳（低级）烷基或任选取代的杂环（低级）烷基; R4是羧基，被保护的羧基或低级烷基磺酰基氨基甲酰基; R5是氢或低级烷基; R6是氢或杂环基; A是单键或低级亚烷基，Ar是具有内皮素拮抗活性的任选取代的芳基或其药学上可接受的盐。

    Method of producing diacetone sorbose
    7.
    依法登记的发明
    Method of producing diacetone sorbose 失效
    双丙酮山梨糖的生产方法

    公开(公告)号：USH708H

    公开(公告)日：1989-11-07

    申请号：US35847

    申请日：1987-04-08

    申请人： Youichi Oka ,  Hitoshi Sawada ,  Masao Yokoyama

    发明人： Youichi Oka ,  Hitoshi Sawada ,  Masao Yokoyama

    IPC分类号： C07B61/00 ,  C07H9/04

    CPC分类号： C07H9/04

    摘要： A method of producing diacetone sorbose by reacting L-sorbose with acetone in the presence of a ketal formation catalyst in acetone, which comprises: carrying out the reaction while continuously removing water generated in the reaction together with acetone and continuously adding to the reaction mixture dehydrated acetone of which water content is not more than about 100 ppm.

    Milk-coagulating enzyme originating in bacterium and process for producing cheese using the same
    9.
    发明申请
    Milk-coagulating enzyme originating in bacterium and process for producing cheese using the same 审中-公开
    源于细菌的凝固凝固酶及使用其的生产奶酪的方法

    公开(公告)号：US20060099317A1

    公开(公告)日：2006-05-11

    申请号：US10518374

    申请日：2003-07-01

    申请人： Daisuke Yasokawa ,  Hitoshi Sawada ,  Ryoji Nakagawa ,  Makoto Kawakami ,  Koji Nagashima ,  Shuhei Miyashita ,  Hiroko Miyashita

    发明人： Daisuke Yasokawa ,  Hitoshi Sawada ,  Ryoji Nakagawa ,  Makoto Kawakami ,  Koji Nagashima ,  Shuhei Miyashita ,  Hiroko Miyashita

    IPC分类号： A23C19/00

    CPC分类号： C12R1/07 ,  A23C19/0326 ,  C12N9/54 ,  C12P21/06

    摘要： The present invention relates to a milk-coagulating enzyme of bacterial origin and a process for producing cheese by using this enzyme, namely, an enzyme that is produced by a bacterium belonging to the genus Paenibacillus and exhibits milk-coagulating activity, characterized by having the following enzymological properties: 1) function: having an activity of coagulating milk to form a curd; 2) substrate specificity: acting on κ-casein as a substrate and specifically cleaving Thr94-Met95 in the presence of calcium; 3) optimum pH: 6.0-7.0, and 4) molecular weight: 35,000-37,000 Da when measured by SDS-PAGE; a process for producing the enzyme; a process for producing cheese; and a cheese-like food product.

    摘要翻译： 本发明涉及一种细菌来源的乳凝固酶，以及使用该酶生产奶酪的方法，即由Paenibacillus属的细菌产生的酶，具有乳凝活性，其特征在于，具有 以下酶学性质：1）功能：具有凝结牛奶以形成凝乳的活性; 2）底物特异性：作用于卡巴酪蛋白作为底物，并在钙存在下特异性切割Thr94-Met95; 3）最适pH：6.0-7.0和4）当通过SDS-PAGE测定时分子量：35,000-37,000Da; 一种生产酶的方法; 生产奶酪的过程; 和奶酪样食品。