公开(公告)号：US08735409B2

公开(公告)日：2014-05-27

申请号：US13513982

申请日：2010-12-21

申请人： Qiang Zhang ,  Hongwen Zhu

发明人： Qiang Zhang ,  Hongwen Zhu

IPC分类号： A01N43/54 ,  A61K31/519 ,  C07D239/72 ,  C07D401/00

CPC分类号： C07D405/12 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/14

摘要： This disclosure concerns novel quinazoline compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful anticancer agents, especially in inhibiting the function of the EGF receptor tyrosine kinases, HER1 tyrosine kinase, and HER2 tyrosine kinase. Thus, the disclosure also concerns a method of treating hyperproliferative diseases or conditions, such as various cancers and benign prostate hyperplasia (BPH), by use of these novel compounds or a composition comprising such novel compounds.

摘要翻译： 本公开涉及如本说明书中定义的式（I）的新颖喹唑啉化合物和包含这些新化合物的组合物。 这些化合物是有用的抗癌剂，特别是抑制EGF受体酪氨酸激酶，HER1酪氨酸激酶和HER2酪氨酸激酶的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物来治疗过度增殖性疾病或病症如各种癌症和良性前列腺增生（BPH）的方法。

公开(公告)号：US20130035350A1

公开(公告)日：2013-02-07

申请号：US13513982

申请日：2010-12-21

申请人： Qiang Zhang ,  Hongwen Zhu

发明人： Qiang Zhang ,  Hongwen Zhu

IPC分类号： C07D239/94 ,  C07D405/12 ,  A61P35/00 ,  A61K31/517

CPC分类号： C07D405/12 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/14

摘要： This disclosure concerns novel quinazoline compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful anticancer agents, especially in inhibiting the function of the EGF receptor tyrosine kinases, HER1 tyrosine kinase, and HER2 tyrosine kinase. Thus, the disclosure also concerns a method of treating hyperproliferative diseases or conditions, such as various cancers and benign prostate hyperplasia (BPH), by use of these novel compounds or a composition comprising such novel compounds.

摘要翻译： 本公开涉及如本说明书中定义的式（I）的新颖喹唑啉化合物和包含这些新化合物的组合物。 这些化合物是有用的抗癌剂，特别是抑制EGF受体酪氨酸激酶，HER1酪氨酸激酶和HER2酪氨酸激酶的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物来治疗过度增殖性疾病或病症如各种癌症和良性前列腺增生（BPH）的方法。

公开(公告)号：US20130310396A1

公开(公告)日：2013-11-21

申请号：US13980788

申请日：2012-01-18

申请人： Hongwen Zhu ,  Qiang Zhang

发明人： Hongwen Zhu ,  Qiang Zhang

IPC分类号： C07D403/12 ,  A61K45/06 ,  A61K31/496

CPC分类号： C07D403/12 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

摘要： This invention provides deuterated thiazolidine derivatives and compositions comprising these compounds, which are useful agents for the treatment of hyperglycemia diseases or disorders, in particular diabetes mellitus. The disclosure also provides a method of treating hyperglycemia diseases or disorders, in particular diabetes mellitus, using these deuterated thiazolidine derivatives.

摘要翻译： 本发明提供氘代噻唑烷衍生物和包含这些化合物的组合物，其是用于治疗高血糖疾病或病症，特别是糖尿病的有用试剂。 本公开还提供了使用这些氘代噻唑烷衍生物治疗高血糖疾病或病症，特别是糖尿病的方法。

公开(公告)号：US09580647B2

公开(公告)日：2017-02-28

申请号：US13637225

申请日：2010-06-30

申请人： David Battaglia ,  Haogua Zhu ,  Qiang Zhang ,  Suresh Sunderrajan ,  Tiecheng Qiao

发明人： David Battaglia ,  Haogua Zhu ,  Qiang Zhang ,  Suresh Sunderrajan ,  Tiecheng Qiao

IPC分类号： C09K11/54 ,  B82Y20/00 ,  C09K11/02 ,  C09K11/88 ,  G02B5/22 ,  H01B1/02 ,  B82Y30/00

CPC分类号： C09K11/54 ,  B82Y20/00 ,  B82Y30/00 ,  C09K11/025 ,  C09K11/883 ,  G02B5/22 ,  G02B2207/101 ,  H01B1/02 ,  Y10S977/774 ,  Y10S977/824

摘要： The present invention relates to low reabsorbing semiconductor nanocrystals having, simultaneously, an emission center core surrounded by at least one absorbing shell capable of absorbing blue or purple light and a protective exterior shell. The emission center core is capable of emitting at least one different wavelength range of light. The low reabsorbing semiconductor nanocrystals demonstrate an absorbance ratio greater than or equal to 10. These low reabsorbing semiconductor nanocrystals can be used in optical applications, some of which can include, for example, light-emitting diodes, solid-state-lighting, solar cells, lasers, and biomedical tags.

摘要翻译： 本发明涉及低再吸收半导体纳米晶体，其同时具有被至少一个吸收蓝色或紫色光的吸收壳包围的发射中心芯和一个保护性外壳。 发射中心芯能够发射至少一种不同波长范围的光。 低重吸收半导体纳米晶体表现出大于或等于10的吸光度比。这些低再吸收半导体纳米晶体可以用于光学应用中，其中一些可以包括例如发光二极管，固态照明，太阳能电池 ，激光和生物医学标签。

公开(公告)号：US09452160B2

公开(公告)日：2016-09-27

申请号：US14742570

申请日：2015-06-17

申请人： Youyi Peng ,  Lawrence P. Wennogle ,  Qiang Zhang ,  John Tomesch

发明人： Youyi Peng ,  Lawrence P. Wennogle ,  Qiang Zhang ,  John Tomesch

IPC分类号： A61K31/445 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/506 ,  A61K33/24 ,  A61K45/06 ,  C07D401/12 ,  A61K31/41 ,  A61K31/415 ,  A61K31/7068

CPC分类号： C07D401/12 ,  A61K31/41 ,  A61K31/415 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： It is an object of the present invention that the novel nicotinic receptor antagonists disclosed herein may be used in a broad array of clinical or medicinal facets. For example, it is a contemplated use of the present invention that the novel nicotinic receptor antagonists be used to inhibit the growth cycle of non-small cell lung cancer cells. Without being bound by theory, it is an object of the present invention that the nicotinic receptor antagonists disclosed herein are believed to possess reversible binding properties. Moreover, the compounds of the present invention are selective for 0.7 nAChR. For example, the compounds of the present invention are not believed to bind to 0.4 (32 nAChR neuromuscular receptors. It is also contemplated that the nicotinic receptor antagonists of the present invention will be used as a counter measure to treat exposure, or potential exposure, to a wide array of potential neurotoxins.

公开(公告)号：US09393135B2

公开(公告)日：2016-07-19

申请号：US11747500

申请日：2007-05-11

申请人： Robert Burgermeister ,  Ramesh Marrey ,  Vipul Bhupendra Dave ,  David Overaker ,  Joseph H. Contiliano ,  Qiang Zhang

发明人： Robert Burgermeister ,  Ramesh Marrey ,  Vipul Bhupendra Dave ,  David Overaker ,  Joseph H. Contiliano ,  Qiang Zhang

IPC分类号： A61F2/915 ,  A61L31/04 ,  A61L31/16 ,  A61L31/18 ,  A61F2/82

CPC分类号： A61F2/915 ,  A61F2/82 ,  A61F2002/825 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2250/0018 ,  A61F2250/0028 ,  A61F2250/0029 ,  A61F2250/0036 ,  A61F2250/0062 ,  A61F2250/0067 ,  A61F2250/0098 ,  A61L31/04 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/416

摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics. The stent has a plurality of hoop components interconnected by a plurality of flexible connectors. The hoop components are formed as a continuous series of substantially longitudinally or axially oriented radial strut members and alternating substantially circumferentially oriented radial arc members. The geometry of the struts and arcs is such that when the stent is expanded, it has very high strains within a relatively small region. This strain localization results in what is often referred to as “hinging”, where the hinge is the small region within which the strains are very high.

摘要翻译： 生物相容性材料可以配置成任何数量的可植入医疗装置，包括腔内支架。 可以使用聚合材料来制造包括支架在内的任何这些装置。 支架可以是球囊扩张或自扩张。 聚合物材料可以包括添加剂如药物或其他生物活性剂以及不透射线剂。 通过聚合物的优先机械变形，聚合物链可以被取向以获得某些所需的性能特征。 支架具有通过多个柔性连接器互连的多个环部件。 环形部件形成为基本纵向或轴向定向的径向支柱构件和交替的基本上周向定向的径向弧形构件的连续系列。 支柱和弧的几何形状使得当支架膨胀时，其在相对小的区域内具有非常高的应变。 这种应变定位导致通常被称为“铰接”，其中铰链是应变非常高的小区域。

公开(公告)号：US09342205B2

公开(公告)日：2016-05-17

申请号：US14342669

申请日：2012-09-04

申请人： Dong Chen ,  Qiang Zhang ,  Yingfeng Ma ,  Zhifeng Xin

发明人： Dong Chen ,  Qiang Zhang ,  Yingfeng Ma ,  Zhifeng Xin

IPC分类号： G06F3/048 ,  G06F3/14

CPC分类号： G06F3/048 ,  G06F1/1616 ,  G06F1/1654 ,  G06F1/1692 ,  G06F3/1446 ,  G06F3/1454 ,  G06F2200/1614 ,  G09G2354/00 ,  G09G2356/00

摘要： Disclosed are a display method, a terminal device and a multi-terminal device system. The display method is applied to a first terminal device and the first terminal device includes a first display unit. The method includes the first display unit displaying a first display interface; detecting a connection with a second terminal device, and obtaining a detection result, the second terminal device including a second display unit displaying a second display interface, and when the detection result indicating that the first terminal device and the second terminal device are connected, one of the first display unit and the second display unit displaying the first display interface, and the other of the first display unit and the second display unit displaying a third display interface, the third display interface and the first display interface being different.

摘要翻译： 公开了一种显示方法，终端装置和多终端装置系统。 显示方法应用于第一终端装置，第一终端装置包括第一显示单元。 该方法包括显示第一显示界面的第一显示单元; 检测与第二终端设备的连接，并获得检测结果，所述第二终端设备包括显示第二显示界面的第二显示单元，当连接了所述第一终端设备和所述第二终端设备的检测结果时， 所述第一显示单元和所述第二显示单元显示所述第一显示界面，所述第一显示单元和所述第二显示单元中的另一个显示第三显示界面，所述第三显示界面和所述第一显示界面不同。

公开(公告)号：US20150344897A1

公开(公告)日：2015-12-03

申请号：US14422661

申请日：2012-09-14

申请人： Haibo Wang ,  Fushuang Dong ,  Mengyu Lv ,  Yanmin Zhang ,  Zhiheng Ren ,  Fan Yang ,  Xinchao Liang ,  Wenbo Zuo ,  Xueping Shi ,  Huanhuan Zhang ,  Yiping Gao ,  He Zhao ,  Xian Xu ,  Guozhong Sun ,  Jianfang Chai ,  Yongwei Liu ,  Jinyong Zhu ,  Qiufen Han ,  Qiang Zhang ,  Huijie Ma ,  Zhanwu Wang ,  Junfeng Guan

发明人： Haibo Wang ,  Fushuang Dong ,  Mengyu Lv ,  Yanmin Zhang ,  Zhiheng Ren ,  Fan Yang ,  Xinchao Liang ,  Wenbo Zuo ,  Xueping Shi ,  Huanhuan Zhang ,  Yiping Gao ,  He Zhao ,  Xian Xu ,  Guozhong Sun ,  Jianfang Chai ,  Yongwei Liu ,  Jinyong Zhu ,  Qiufen Han ,  Qiang Zhang ,  Huijie Ma ,  Zhanwu Wang ,  Junfeng Guan

IPC分类号： C12N15/82

CPC分类号： C12N15/8205 ,  C12N15/8207

摘要： The present invention is a method of shoot apical meristem transformation for monocot plant via sufficient and micro wounding (SMW). The technical process includes: expose the apical meristem by removing the coleoptile away when the shoot grows to 0.2-2 cm after 1-2 days of seed germination; make sufficient and micro wounding transformation to the apical meristem by stabbing and brushing for 2-3 times using the SMW brush having 100-5000 bristles which is 4-20 μm in diameter for each one and 0.5-3 mm in exposed length, and dipped with the Agrobacterium tumefaciens containing binary vector harboring exogenous genes; develop the treated meristems directly to normal plants after co-cultivation; promote the plants to develop big spikes and set more seeds; harvest the seeds of T0 plants separately; detect and identify the transformation results in T1 generation which is bred from each individual T0 plant. The advantages of the invention are independent of tissue culture, unlimited in genotype, unnecessary to carry resistant marker, simple and large scale to perform, and applicable to all monocot plants which can set seeds. The transformation efficiencies for wheat, rice and maize using this method are 49%, 66.3%, and 100%, respectively.

摘要翻译： 本发明是通过足够和微伤（SMW）的单子叶植物的茎顶分生组织转化的方法。 技术过程包括：通过在种子发芽1-2天后枝条生长至0.2-2厘米时，通过去除胚芽鞘来揭开顶端分生组织; 使用具有直径为4-20μm，暴露长度为0.5-3mm的直径为4-20μm的100-5000个刷毛的SMW刷，通过刺入和刷刷2-3次来对顶端分生组织进行充分和微小的伤口转化，并浸渍 含有包含外源基因的二元载体的根癌农杆菌; 共培养后将经处理的分生组织直接发育至正常植物; 促进植物发展大穗，种植更多种子; 分别收获T0植物的种子; 检测和识别从每个T0植物繁殖的T1代转化结果。 本发明的优点独立于组织培养，基因型无限，不需携带抗性标记，简单大规模进行，适用于可以设置种子的所有单子叶植物。 使用该方法对小麦，水稻和玉米的转化效率分别为49％，66.3％和100％。

公开(公告)号：US09119125B2

公开(公告)日：2015-08-25

申请号：US14009463

申请日：2011-04-06

申请人： Jonas Fröberg Olsson ,  Qiang Zhang

发明人： Jonas Fröberg Olsson ,  Qiang Zhang

IPC分类号： H04W36/20 ,  H04W36/00 ,  H04L1/00 ,  H04L1/18

CPC分类号： H04W36/20 ,  H04L1/00 ,  H04L1/1867 ,  H04W36/00 ,  H04W36/0016

摘要： Methods and arrangements (600) in a first network node (120-1) for managing handover of a user equipment (110) from the first network node (120-1), to a second network node (120-2). The method and arrangement (600) comprises transmitting (501) a handover message to the user equipment (110), which handover message is triggering the user equipment (110) to perform the handover, and to establishing (502) a limit related to the amount of retransmissions to be made. Further the method and arrangement (600) comprises interrupting (503) scheduling of resources to the user equipment (110) and inhibiting further retransmissions of the handover message, when either the established limit is reached, or an indication that the user equipment (110) has left the first cell (130-1) is received. Also, methods and arrangements (800) in a in a second network node (120-2) are disclosed.

摘要翻译： 用于管理用户设备（110）从第一网络节点（120-1）切换到第二网络节点（120-2）的第一网络节点（120-1）中的方法和布置（600）。 所述方法和装置（600）包括向所述用户设备（110）发送切换消息（501），所述切换消息正在触发所述用户设备（110）执行所述切换，以及建立（502）与所述用户设备 重新发送的数量。 此外，所述方法和装置（600）包括中断（503）向所述用户设备（110）的资源调度，并且当达到所建立的限制时，禁止进一步重传所述切换消息，或者指示所述用户设备（110） 已经离开接收到第一小区（130-1）。 此外，公开了第二网络节点（120-2）中的方法和布置（800）。

公开(公告)号：US09034353B2

公开(公告)日：2015-05-19

申请号：US12850676

申请日：2010-08-05

申请人： Robert J. Ehr ,  Thomas H. Kalantar ,  Lei Liu ,  Dale C. Schmidt ,  Mike P. Tolley ,  Kerrm Y. Yau ,  Qiang Zhang ,  Min Zhao

发明人： Robert J. Ehr ,  Thomas H. Kalantar ,  Lei Liu ,  Dale C. Schmidt ,  Mike P. Tolley ,  Kerrm Y. Yau ,  Qiang Zhang ,  Min Zhao

IPC分类号： A01N25/34 ,  A01N25/32 ,  A01N43/72 ,  A01N25/28

CPC分类号： A01N25/28 ,  A01N43/22 ,  A01N43/40 ,  A01N43/653 ,  A01N43/70 ,  A01N47/38 ,  A01N2300/00

摘要： Disclosed herein are mesocapsules that include agriculturally active ingredients. These mesocapsules are comprised of a polyurea shell and include hydrophilic groups on their surfaces and have a volume-average diameter of about 500 nm or less and some of them have a volume-average diameter on the order of about 300 nm or less. These mesocapsules are suited for delivering active ingredients that are not very soluble in water. Methods for making these mesocapsules include interfacial polycondensation reactions carried out in the presence of surfactants and other methods in which all or most of the surfactant is replaced by adding amino acids to the aqueous phase of the interfacial reaction mixture before forming the final emulsion.

摘要翻译： 本文公开了包含农业活性成分的中间胶囊。 这些中间胶囊由聚脲壳组成并且在其表面上包括亲水基团并且具有约500nm或更小的体积平均直径，并且它们中的一些具有约300nm或更小量级的体积平均直径。 这些mesocapsules适用于递送不太溶于水的活性成分。 制备这些中间胶囊的方法包括在表面活性剂和其它方法下进行的界面缩聚反应，其中在形成最终乳液之前，通过向界面反应混合物的水相中加入氨基酸来代替所有或大部分表面活性剂。