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1.发明授权公开(公告)号：US12020477B2
公开(公告)日：2024-06-25
申请号：US18110415
申请日：2023-02-16
IPC分类号： G06K9/00 , G06F16/532 , G06F16/55 , G06F16/56 , G06T7/10 , G06T9/00 , G06V10/44 , G06V10/762 , G06V10/764 , G06V10/77 , G06V10/82
CPC分类号： G06V10/82 , G06F16/532 , G06F16/55 , G06F16/56 , G06T7/10 , G06T9/002 , G06V10/44 , G06V10/762 , G06V10/764 , G06V10/77 , G06T2207/20021
摘要： Computer-implemented methods and systems are provided for generating encoded representations for multiple magnifications of one or more query images. An example method for involves operating a processor to obtain a query image and identify a set of anchor points within the query image. The processor is operable to generate a plurality of sub-images for a plurality of magnification levels for each anchor point. Each sub-image includes the anchor point and corresponds to a magnification level of the plurality of magnification levels. The processor is operable to, for each magnification level, apply an artificial neural network model to a group of sub-images having that magnification level to extract a feature vector representative of image characteristics of the query image at that magnification level; and to generate an encoded representation for multiple magnifications of the query image based on the feature vectors extracted for the plurality of magnification levels.
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公开(公告)号：US20190018231A1
公开(公告)日：2019-01-17
申请号：US16066354
申请日：2017-05-19
发明人： Arthur Edward Dixon
摘要： A scanning microscope and method of operation has a scan filter with a repeat pattern of a plurality of rows that is repeated at least across an active area of an entire surface of an area detector. Each row is covered by a bandpass filter or an emission filter for a specific fluorophore or filters of a particular colour for each row. The scanning microscope can be used to obtain one or more of hyperspectral images, multispectral images, RGB images, RGBW images, W images and Single Field Of View images of a specimen using Moving Specimen Image Averaging. A method of obtaining one or more of the images is also described.
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公开(公告)号：US20150109432A1
公开(公告)日：2015-04-23
申请号：US14382277
申请日：2013-03-04
CPC分类号： G02B21/008 , G01N21/6456 , G01N21/6458 , G01N2021/6417 , G02B21/0076 , G02B21/367
摘要： An instrument and method for scanning all or part of a large specimen mounted on a specimen holder takes a plurality of measurements of each pixel in the whole or part of the specimen being scanned at a plurality of exposure values. A computer controls the movement of the specimen holder during scanning and again of the detector to produce a digitized image of all or part of the specimen with larger dynamic range than the dynamic range of the detection system. In a further embodiment, the instrument can scan two successive, identical strips at a different exposure values and combine the images from the two scans into one digitized image having a larger dynamic range than the dynamic range of the detection system.
摘要翻译： 用于扫描安装在样本保持器上的大样本的全部或部分的仪器和方法以多个曝光值对被扫描的全部或部分待检体中的每个像素进行多次测量。 计算机在扫描期间控制样品架的运动，并再次检测检测器，以产生具有比检测系统的动态范围更大的动态范围的全部或部分样品的数字化图像。 在另一个实施例中，仪器可以以不同的曝光值扫描两个连续的相同的条，并将来自两个扫描的图像组合成具有比检测系统的动态范围更大的动态范围的一个数字化图像。
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公开(公告)号：US09804376B2
公开(公告)日：2017-10-31
申请号：US14382277
申请日：2013-03-04
CPC分类号： G02B21/008 , G01N21/6456 , G01N21/6458 , G01N2021/6417 , G02B21/0076 , G02B21/367
摘要： An instrument and method for scanning all or part of a large specimen mounted on a specimen holder takes a plurality of measurements of each pixel in the whole or part of the specimen being scanned at a plurality of exposure values. A computer controls the movement of the specimen holder during scanning and again of the detector to produce a digitized image of all or part of the specimen with larger dynamic range than the dynamic range of the detection system. In a further embodiment, the instrument can scan two successive, identical strips at a different exposure values and combine the images from the two scans into one digitized image having a larger dynamic range than the dynamic range of the detection system.
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5.发明授权公开(公告)号：US09575308B2
公开(公告)日：2017-02-21
申请号：US14387457
申请日：2013-03-21
CPC分类号： G02B21/365 , G02B21/006 , G02B21/0076 , G02B21/008 , G02B21/12 , G02B21/16 , G02B21/26
摘要： An instrument and method for scanning large microscope specimen on a specimen holder has a scanning optical microscope that is configured to scan the specimen in one of brightfield and fluorescence. The specimen is dynamically tillable about a scan direction during a scan to maintain focus along the length of each scan line as the scan proceeds. A three dimensional image of the specimen can be obtained wherein the specimen tilt and relative focus are maintained from a first image contour to a second image contour through a thickness of a specimen.
摘要翻译： 用于扫描样本支架上的大显微镜样本的仪器和方法具有扫描光学显微镜，其配置为以明场和荧光之一扫描样本。 在扫描过程中，样本可以围绕扫描方向动态切割，以便在扫描进行时沿着每条扫描线的长度保持对焦。 可以获得样本的三维图像，其中样本倾斜和相对聚焦通过样本的厚度从第一图像轮廓维持到第二图像轮廓。
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公开(公告)号：US20160004062A1
公开(公告)日：2016-01-07
申请号：US14770427
申请日：2014-02-25
发明人： Arthur Edward Dixon
IPC分类号： G02B21/36 , G02B21/02 , G02B21/08 , H04N7/18 , G06T3/40 , H04N5/374 , H04N5/232 , G06T7/20 , G06T7/00 , G06T7/40 , G02B21/16 , H04N5/372
CPC分类号： G02B21/36 , G02B21/025 , G02B21/082 , G02B21/16 , G06T3/4038 , G06T7/11 , G06T7/187 , G06T7/20 , G06T7/90 , G06T2207/10024 , G06T2207/10061 , G06T2207/10064 , G06T2207/10144 , G06T2207/30004 , G06T2210/41 , H04N5/23296 , H04N5/372 , H04N5/374 , H04N7/183
摘要： An instrument and a method of scanning a large microscope specimen moves the specimen relative to a detector array during scanning by a scanner. Magnification of the instrument is adjustable using a zoom tube lens over a continuous range of magnification to enable scans of the specimen to be taken over a range of resolutions without varying the infinity corrective objective. Scans of the specimen can be taken over a range of resolutions with the same infinity connected objective.
摘要翻译： 扫描大型显微镜样本的仪器和方法使扫描仪扫描期间样品相对于检测器阵列移动。 使用变焦管镜头可以在连续放大倍数范围内使用变焦管镜头进行放大倍数，以使样本的扫描能够在一定范围的分辨率下进行，而无需改变无穷大的校正目标。 标本的扫描可以采用相同无穷远相关目标的一系列分辨率。
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公开(公告)号：US11269171B2
公开(公告)日：2022-03-08
申请号：US16066354
申请日：2017-05-19
发明人： Arthur Edward Dixon
摘要： A scanning microscope and method of operation has a scan filter with a repeat pattern of a plurality of rows that is repeated at least across an active area of an entire surface of an area detector. Each row is covered by a bandpass filter or an emission filter for a specific fluorophore or filters of a particular colour for each row. The scanning microscope can be used to obtain one or more of hyperspectral images, multispectral images, RGB images, RGBW images, W images and Single Field Of View images of a specimen using Moving Specimen Image Averaging. A method of obtaining one or more of the images is also described.
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公开(公告)号：US20210278648A1
公开(公告)日：2021-09-09
申请号：US16328644
申请日：2017-08-25
发明人： Arthur Edward Dixon
摘要： A mosaic scan filter array has a plurality of identical tiles, each tile have n rows and m columns where n is equal to a greater than 1 and m is equal to a greater than 2. One row of tiles extends a width of a detector array and constitutes a base pattern. The base pattern is repeated M times and each repetition is laterally offset in one direction by one pixel width. The base pattern and laterally offset repetitions constitute a repeat pattern. There are M×N filters selected from the group of one or more of the following: RGBW filters, fluorescence emission filters and a series of narrow spectral band filters covering a continuous spectral range. The mosaic scan filter arrays can be used with a scanning microscope or a scanning camera.
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公开(公告)号：US09632301B2
公开(公告)日：2017-04-25
申请号：US14346661
申请日：2012-09-21
IPC分类号： G02B7/04 , G02B21/06 , B82Y35/00 , G02B21/00 , G01N21/64 , G02B21/16 , G02B21/34 , G02B21/36
CPC分类号： G02B21/06 , B82Y35/00 , G01N21/6456 , G02B21/002 , G02B21/16 , G02B21/34 , G02B21/367
摘要： An instrument and method for scanning a large microscope specimen uses a light source and at least one lens to focus light from the specimen onto a detector array. The specimen holder is located on a scanning stage and the detector array is dynamically tilted about a scan direction during the scan to maintain focus across the width of the scan strip as the scan proceeds. A degree of tilt varies during the scan as is required to maintain lateral focus relative to the detector array.
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10.发明申请SLIDE SCANNER WITH DYNAMIC FOCUS AND SPECIMEN TILT AND METHOD OF OPERATION 有权具有动态聚焦和样本倾斜的滑动扫描仪及其操作方法公开(公告)号：US20150054921A1
公开(公告)日：2015-02-26
申请号：US14387457
申请日：2013-03-21
CPC分类号： G02B21/365 , G02B21/006 , G02B21/0076 , G02B21/008 , G02B21/12 , G02B21/16 , G02B21/26
摘要： An instrument and method for scanning large microscope specimen on a specimen holder has a scanning optical microscope that is configured to scan the specimen in one of brightfield and fluorescence. The specimen is dynamically tillable about a scan direction during a scan to maintain focus along the length of each scan line as the scan proceeds. A three dimensional image of the specimen can be obtained wherein the specimen tilt and relative focus are maintained from a first image contour to a second image contour through a thickness of a specimen.
摘要翻译： 用于扫描样本支架上的大显微镜样本的仪器和方法具有扫描光学显微镜，其配置为以明场和荧光之一扫描样本。 在扫描过程中，样本可以围绕扫描方向动态切割，以便在扫描进行时沿着每条扫描线的长度保持对焦。 可以获得样本的三维图像，其中样本倾斜和相对聚焦通过样本的厚度从第一图像轮廓维持到第二图像轮廓。
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