利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.023 秒)

    Templated native silk smectic gels
    1.
    发明申请
    Templated native silk smectic gels 有权

    公开(公告)号：US20060205927A1

    公开(公告)日：2006-09-14

    申请号：US10533611

    申请日：2003-10-31

    申请人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    发明人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    IPC分类号： C07K14/78 ,  C07K14/435

    CPC分类号： A61K47/42 ,  C07K14/43586 ,  Y10T436/25375

    摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.

    Templated Native Silk Smectic Gels
    2.
    发明申请
    Templated Native Silk Smectic Gels 有权
    模板本地丝绸水晶凝胶

    公开(公告)号：US20100294716A1

    公开(公告)日：2010-11-25

    申请号：US12536793

    申请日：2009-08-06

    申请人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    发明人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    IPC分类号： B01D15/08 ,  B01D59/26 ,  C07K14/435 ,  B32B9/02 ,  C12N9/00 ,  C09K3/00 ,  B01J31/02

    CPC分类号： A61K47/42 ,  C07K14/43586 ,  Y10T436/25375

    摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.

    摘要翻译： 本发明的一个方面涉及一种通过溶剂模板法制备纤维蛋白质近晶水凝胶的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 并收集所得到的纤维蛋白质近晶凝胶并使其干燥。 本发明的另一方面涉及从外消旋混合物主要获得一种对映异构体的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 允许外消旋混合物的对映体选择性地扩散到溶液中的近晶水凝胶中; 从溶液中除去近晶凝胶; 从近晶水凝胶的表面主要漂洗一种对映异构体; 并从近晶水凝胶的内部主要提取一种对映异构体。 本发明还涉及根据上述方法制备的近晶型水凝胶。

    Templated native silk smectic gels
    3.
    发明授权
    Templated native silk smectic gels 有权

    公开(公告)号：US08580924B2

    公开(公告)日：2013-11-12

    申请号：US12536793

    申请日：2009-08-06

    申请人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    发明人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    IPC分类号： A61K38/17

    CPC分类号： A61K47/42 ,  C07K14/43586 ,  Y10T436/25375

    摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.

    Templated native silk smectic gels
    4.
    发明授权
    Templated native silk smectic gels 有权
    模板的天然丝状近晶凝胶

    公开(公告)号：US07572894B2

    公开(公告)日：2009-08-11

    申请号：US10533611

    申请日：2003-10-31

    申请人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    发明人： Hyoung-Joon Jin ,  Jae-Hyung Park ,  Regina Valluzzi

    IPC分类号： C07K14/00 ,  G01N33/50

    CPC分类号： A61K47/42 ,  C07K14/43586 ,  Y10T436/25375

    摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.

    摘要翻译： 本发明的一个方面涉及一种通过溶剂模板法制备纤维蛋白质近晶水凝胶的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 并收集所得到的纤维蛋白质近晶凝胶并使其干燥。 本发明的另一方面涉及从外消旋混合物主要获得一种对映异构体的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 允许外消旋混合物的对映体选择性扩散到溶液中的近晶水凝胶中; 从溶液中除去近晶凝胶; 从近晶水凝胶的表面主要漂洗一种对映异构体; 并从近晶水凝胶的内部主要提取一种对映异构体。 本发明还涉及根据上述方法制备的近晶型水凝胶。

    Silk biomaterials and methods of use thereof
    8.
    发明授权
    Silk biomaterials and methods of use thereof 有权
    丝素生物材料及其使用方法

    公开(公告)号：US08071722B2

    公开(公告)日：2011-12-06

    申请号：US12688014

    申请日：2010-01-15

    申请人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    发明人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    IPC分类号： A61K38/00 ,  C07K14/00

    CPC分类号： D01D5/0038 ,  A61L27/227 ,  A61L27/3604 ,  D01F1/02 ,  D01F4/02 ,  D01F6/94 ,  D06M13/17 ,  D06M15/03 ,  D06M15/11 ,  A61L27/48 ,  C08L71/02 ,  A61L27/44

    摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.

    摘要翻译： 本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。 在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。 我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。 此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

    SILK BIOMATERIALS AND METHODS OF USE THEREOF
    9.
    发明申请
    SILK BIOMATERIALS AND METHODS OF USE THEREOF 有权
    丝状生物材料及其使用方法

    公开(公告)号：US20100196447A1

    公开(公告)日：2010-08-05

    申请号：US12688014

    申请日：2010-01-15

    申请人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    发明人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    IPC分类号： A61K9/70 ,  A61K31/56 ,  A61K38/30 ,  A61K38/16 ,  A61K31/715 ,  A61K47/42 ,  A61P17/02

    CPC分类号： D01D5/0038 ,  A61L27/227 ,  A61L27/3604 ,  D01F1/02 ,  D01F4/02 ,  D01F6/94 ,  D06M13/17 ,  D06M15/03 ,  D06M15/11 ,  A61L27/48 ,  C08L71/02 ,  A61L27/44

    摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.

    摘要翻译： 本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。 在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。 我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。 此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

    Silk biomaterials and methods of use thereof
    10.
    发明授权
    Silk biomaterials and methods of use thereof 有权
    丝素生物材料及其使用方法

    公开(公告)号：US07674882B2

    公开(公告)日：2010-03-09

    申请号：US11020650

    申请日：2004-12-23

    申请人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    发明人： David L. Kaplan ,  Hyoung-Joon Jin ,  Gregory Rutledge ,  Sergey Fridrikh

    IPC分类号： A61K38/17 ,  A61L15/00

    CPC分类号： D01D5/0038 ,  A61L27/227 ,  A61L27/3604 ,  D01F1/02 ,  D01F4/02 ,  D01F6/94 ,  D06M13/17 ,  D06M15/03 ,  D06M15/11 ,  A61L27/48 ,  C08L71/02 ,  A61L27/44

    摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.

    摘要翻译： 本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。 在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。 我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。 此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。