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    DYNAMIC DETILT FOCUS TRACKING
    1.
    发明公开
    DYNAMIC DETILT FOCUS TRACKING 审中-公开

    公开(公告)号：US20230228984A1

    公开(公告)日：2023-07-20

    申请号：US18097947

    申请日：2023-01-17

    Applicant: ILLUMINA, INC.

    Inventor： Dakota Watson ,  Merek Siu ,  Dustin Blair ,  Danilo Condello ,  John Earney ,  Paul Sangiorgio

    IPC: G02B21/24 ,  G02B21/26 ,  G02B21/00 ,  H04N23/56

    CPC classification number: G02B21/245 ,  G02B21/26 ,  G02B21/0036 ,  G02B21/0032 ,  H04N23/56 ,  G02B21/0076 ,  G02B21/362

    Abstract: Some implementations of the disclosure relate to an imaging system, including: a sample holder to support a sample container having multiple sample locations; an optical stage having; an assembly comprising one or more actuators physically coupled to the sample holder to tilt the sample holder relative to the optical stage during imaging of the multiple sample locations to focus the optical stage onto a current sample location; a first light source to project a first pair of spots on the sample container; and a controller to control, based on a sample tilt determined from a first separation measurement of the first pair of spots from one or more images taken by an image sensor at one or more of the sample locations, the one or more actuators to tilt the sample holder along a first direction of the imaging or a second direction substantially perpendicular to the first direction.

    DETILT FOCUS TRACKING
    3.
    发明申请
    DETILT FOCUS TRACKING 有权

    公开(公告)号：US20250004244A1

    公开(公告)日：2025-01-02

    申请号：US18759291

    申请日：2024-06-28

    Applicant: ILLUMINA, INC.

    Inventor： Dustin Blair ,  Gregory Holst ,  Merek Siu ,  Paul Sangiorgio ,  Dakota Watson ,  Danilo Condello ,  John Earney ,  Peter Newman

    IPC: G02B7/40 ,  G02B26/08

    Abstract: An imaging system includes a focus tracking module including: a light source to project a first pair of spots on a sample; and a first image sensor to obtain one or more first images of the first pair of spots; a second image sensor to obtain one or more second images of the sample; one or more mirrors optically coupled to the second image sensor, the one or more mirrors positioned in an optical path from the sample to the second image sensor; and a controller to: determine, using at least a first separation distance measurement of the first pair of spots from the one or more first images, a first sample tilt of the sample about a first axis of the imaging system; and actuate, based at least on the first sample tilt, the one or more mirrors to offset the first sample tilt about the first axis.

    METHOD FOR REDUCING VIBRATION USING SEGMENTED ACCELERATION
    4.
    发明公开
    METHOD FOR REDUCING VIBRATION USING SEGMENTED ACCELERATION 审中-公开

    公开(公告)号：US20240118203A1

    公开(公告)日：2024-04-11

    申请号：US18373592

    申请日：2023-09-27

    Applicant: Illumina, Inc.

    Inventor： Shavinesh Sukesh ,  Chia-Hsi Liu ,  Gregory Holst ,  Ahmed Okasha ,  Kurt Danielson ,  John Earney

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  G01N2201/025 ,  G01N2201/068

    Abstract: The motion of a mechanical stage may be directed in x-, y-, and/or z-dimensions such that excitation of a resonant frequency f is reduced. In particular, once a resonant frequency f is identified, the acceleration of the stage in the x-, y-, and/or z-dimensions may divided into an even number of acceleration segments or intervals, with the second of each pair of acceleration segments starting 1/(2f) seconds after the start of the initial acceleration segment. The acceleration intervals may be defined by a start time, an amplitude profile, and/or a time duration. In some implementations, the amplitude and time duration of each acceleration pulse may be different. The amplitude and time duration of acceleration steps may be determined and adjusted to compensate for the particular resonance frequency of an individual system, and programmed into a controller for the stage using motor programming controls.

    SPOT ERROR HANDLING FOR FOCUS TRACKING
    5.
    发明公开
    SPOT ERROR HANDLING FOR FOCUS TRACKING 审中-公开

    公开(公告)号：US20240114243A1

    公开(公告)日：2024-04-04

    申请号：US18474026

    申请日：2023-09-25

    Applicant: ILLUMINA, INC.

    Inventor： Yu Chen ,  Gregory Holst ,  John Earney ,  Patrick Wen ,  Chia-Hsi Liu ,  Daeyong Sim

    IPC: H04N23/67 ,  G06V10/141 ,  G06V10/60 ,  G06V10/74

    CPC classification number: H04N23/675 ,  G06V10/141 ,  G06V10/60 ,  G06V10/761

    Abstract: Some implementations of the disclosure relate to an imaging system including one or more image sensors and a Z-stage. The imaging system is configured to perform operations including: capturing, using the one or more image sensors, a first image of a first pair of spots projected at a first sample location of a sample; determining whether or not the first image of the first pair of spots is valid; and when the first image is determined to be valid: obtaining, based on the first image, a current separation distance measurement of the first pair of spots; and controlling, based at least on the current separation distance measurement, the Z-stage to focus the imaging system at the first sample location.

    OPTICAL ALIGNMENT TARGETS
    7.
    发明申请
    OPTICAL ALIGNMENT TARGETS 有权

    公开(公告)号：US20250052565A1

    公开(公告)日：2025-02-13

    申请号：US18799507

    申请日：2024-08-09

    Applicant: ILLUMINA, INC.

    Inventor： Shamsul Abedin ,  John Earney ,  Charles Hubert ,  Joseph Pinto ,  Arthur Pitera ,  Spencer Williams ,  Brandon Wenning ,  Clayton Braga

    IPC: G01B11/27

    Abstract: An example optical alignment target includes a translucent or transparent substrate having a bottom surface; an opaque material formed over the bottom surface in a pattern; an enclosed channel disposed below the bottom surface; and a fluid suspension contained in the enclosed channel. The pattern has an opaque portion of an opaque material and has a gap portion devoid of the opaque material. The fluid suspension includes a carrier liquid and a light emitting material suspended in the carrier liquid. The light emitting material is selected from the group consisting of quantum dots and cerium powder.

    FLOW CELL BASED MOTION SYSTEM CALIBRATION AND CONTROL METHODS
    8.
    发明公开
    FLOW CELL BASED MOTION SYSTEM CALIBRATION AND CONTROL METHODS 审中-公开

    公开(公告)号：US20240100518A1

    公开(公告)日：2024-03-28

    申请号：US18474589

    申请日：2023-09-26

    Applicant: ILLUMINA, INC.

    Inventor： Matthew Hage ,  John Earney ,  Gregory Holst ,  Mark Majette

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0893 ,  B01L2300/0896

    Abstract: The presently described techniques relate generally to providing motion feedback (e.g., motion system calibration and/or sample alignment) in the context of an imaging system (such as a time delay and integration (TDI) based imaging system). The architecture and techniques discussed may achieve nanoscale control and calibration of a movement feedback system without a high-resolution encoder subsystem or, in the alternative embodiments, with a lower resolution (and correspondingly less expensive) encoder subsystem than might otherwise be employed. By way of example, certain embodiments described herein relate to ascertaining or calibrating linear motion of a sample holder surface using nanoscale features (e.g., sample sites or nanowells or lithographically patterned features) provided on a surface of the sample holder.

    APPARATUS AND METHOD FOR CAPTURING VIBRATION IN SYSTEM
    9.
    发明公开
    APPARATUS AND METHOD FOR CAPTURING VIBRATION IN SYSTEM 审中-公开

    公开(公告)号：US20230272837A1

    公开(公告)日：2023-08-31

    申请号：US18113815

    申请日：2023-02-24

    Applicant: ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

    Inventor： Gregory Holst ,  Dustin Blair ,  John Earney ,  Geraint Evans ,  Matthew Hage

    IPC: F16F15/03

    CPC classification number: F16F15/035 ,  F16F2230/0047

    Abstract: An apparatus includes a chassis, a frame, a sample support member, an imaging assembly, an actuation assembly, and a vibration capture assembly. The frame is coupled with the chassis. The sample support member is supported by the frame. The actuation assembly is supported by the frame and is operable to drive movement of the imaging assembly relative to the sample support member. The vibration capture assembly is operable to selectively transition between a plurality of modes, including a damping mode and an isolation mode. In the damping mode, the vibration capture assembly is configured to resist movement of the frame relative to the chassis in response to operation of the actuation assembly. In the isolation mode, the vibration capture assembly is configured to prevent transmission of vibrational movement in the chassis to the frame.

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