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1.发明申请FLUIDIC CARTRIDGES, SYSTEMS, AND METHODS FOR CONDUCTING BIOCHEMICAL REACTIONS 有权用于引导生物化学反应的流体药盒，系统和方法公开(公告)号：US20160089668A1
公开(公告)日：2016-03-31
申请号：US14858311
申请日：2015-09-18
申请人： Illumina, Inc.
CPC分类号： B01L3/502 , B01L3/523 , B01L3/527 , B01L2200/026 , B01L2200/028 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , C12Q1/6846 , C12Q1/686
摘要： Fluidic cartridge including a liquid container having a reservoir configured to hold a liquid. The liquid container includes an interior surface. The fluidic cartridge also includes a transfer tube that extends from the interior surface to a distal end. The distal end includes a fluidic port that is in flow communication with the reservoir through the transfer tube. The transfer tube has a piercing segment that includes the distal end. The fluidic cartridge also includes a movable seal that is engaged to the piercing segment of the transfer tube and configured to slide along the piercing segment from a closed position to a displaced position during a mating operation. The movable seal blocks flow of the liquid through the fluidic port when in the closed position. The piercing segment extends through the movable seal when in the displaced position.
摘要翻译： 流体盒包括具有容纳液体的储存器的液体容器。 液体容器包括内表面。 流体盒还包括从内表面延伸到远端的传送管。 远端包括通过传送管与储存器流动连通的流体端口。 传送管具有包括远端的刺穿段。 流体盒还包括可移动密封件，该可移动密封件接合到传送管的刺穿部分并且被配置成在配合操作期间沿着穿刺部分从关闭位置滑动到位移位置。 可移动密封件在处于关闭位置时阻止液体通过流体端口的流动。 当处于移动位置时，刺穿段延伸穿过可移动密封件。
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公开(公告)号：US11786898B2
公开(公告)日：2023-10-17
申请号：US16818953
申请日：2020-03-13
申请人： Illumina, Inc.
发明人： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
IPC分类号： B01L3/00 , B01L7/00 , F16K99/00 , G01N35/08 , C12Q1/6869
CPC分类号： B01L3/502738 , B01L3/50273 , B01L3/502715 , B01L7/52 , C12Q1/6869 , F16K99/0013 , F16K99/0015 , F16K99/0028 , G01N35/08 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , F16K2099/0084
摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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3.发明申请MICRODEVICES AND BIOSENSOR CARTRIDGES FOR BIOLOGICAL OR CHEMICAL ANALYSIS AND SYSTEMS AND METHODS FOR THE SAME 有权用于生物或化学分析和系统的MICRODEVICES和生物传感器盒及其相关方法公开(公告)号：US20150266022A1
公开(公告)日：2015-09-24
申请号：US14729809
申请日：2015-06-03
申请人： ILLUMINA, INC.
CPC分类号： B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , C12Q1/6869 , C12Q1/6874
摘要： A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
摘要翻译： 一种流动池，包括通过其间在其间延伸的流动通道彼此流体连通的入口和出口。 流动通道包括扩散器区域和位于扩散器区域下游的场区域。 流动通道的场区域沿着发生所需反应的反应位置引导流体。 流体在第一流动方向上流过扩散器区域并且在第二流动方向上流过场区域。 第一和第二流动方向基本垂直。
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4.发明申请公开(公告)号：US20200206737A1
公开(公告)日：2020-07-02
申请号：US16818953
申请日：2020-03-13
申请人： Illumina, Inc.
发明人： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
IPC分类号： B01L3/00 , F16K99/00 , C12Q1/6869 , B01L7/00 , G01N35/08
摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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公开(公告)号：US09839910B2
公开(公告)日：2017-12-12
申请号：US14858311
申请日：2015-09-18
申请人： Illumina, Inc.
CPC分类号： B01L3/502 , B01L3/523 , B01L3/527 , B01L2200/026 , B01L2200/028 , B01L2200/0689 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , C12Q1/6846 , C12Q1/686
摘要： Fluidic cartridge including a liquid container having a reservoir configured to hold a liquid. The liquid container includes an interior surface. The fluidic cartridge also includes a transfer tube that extends from the interior surface to a distal end. The distal end includes a fluidic port that is in flow communication with the reservoir through the transfer tube. The transfer tube has a piercing segment that includes the distal end. The fluidic cartridge also includes a movable seal that is engaged to the piercing segment of the transfer tube and configured to slide along the piercing segment from a closed position to a displaced position during a mating operation. The movable seal blocks flow of the liquid through the fluidic port when in the closed position. The piercing segment extends through the movable seal when in the displaced position.
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6.发明申请公开(公告)号：US20170144155A1
公开(公告)日：2017-05-25
申请号：US15315638
申请日：2015-06-03
申请人： ILLUMINA, INC.
发明人： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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公开(公告)号：US20160318017A1
公开(公告)日：2016-11-03
申请号：US15205275
申请日：2016-07-08
申请人： Illumina, Inc.
CPC分类号： B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , C12Q1/6869 , C12Q1/6874
摘要： A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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公开(公告)号：US12048928B2
公开(公告)日：2024-07-30
申请号：US17848840
申请日：2022-06-24
申请人： Illumina, Inc.
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/6869 , C12Q1/6874
CPC分类号： B01L3/502715 , B01L3/5085 , B01L7/52 , C12Q1/6869 , C12Q1/6874 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622
摘要： A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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9.发明公开公开(公告)号：US20240001361A1
公开(公告)日：2024-01-04
申请号：US18369587
申请日：2023-09-18
申请人： ILLUMINA, INC.
发明人： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Kumar Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
IPC分类号： B01L3/00 , B01L7/00 , F16K99/00 , G01N35/08 , C12Q1/6869
CPC分类号： B01L3/502738 , B01L3/50273 , B01L7/52 , F16K99/0013 , F16K99/0028 , F16K99/0015 , G01N35/08 , B01L3/502715 , C12Q1/6869 , B01L2400/0644 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , F16K2099/0084 , B01L2400/0655
摘要： Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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10.发明申请公开(公告)号：US20190351414A1
公开(公告)日：2019-11-21
申请号：US16529397
申请日：2019-08-01
申请人： Illumina, Inc.
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/6874 , C12Q1/6869
摘要： A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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