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公开(公告)号：US11786898B2
公开(公告)日：2023-10-17
申请号：US16818953
申请日：2020-03-13
Applicant: Illumina, Inc.
Inventor： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
IPC: B01L3/00 , B01L7/00 , F16K99/00 , G01N35/08 , C12Q1/6869
CPC classification number: B01L3/502738 , B01L3/50273 , B01L3/502715 , B01L7/52 , C12Q1/6869 , F16K99/0013 , F16K99/0015 , F16K99/0028 , G01N35/08 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , F16K2099/0084
Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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公开(公告)号：US09309571B2
公开(公告)日：2016-04-12
申请号：US14084355
申请日：2013-11-19
Applicant: ILLUMINA, INC.
Inventor： Min-Jui Richard Shen , Robert C. Kain , Kenneth M. Kuhn , AmirAli Hajhossein Talasaz , Arash Jamshidi , George Sakaldasis , Eric Vermaas , Sebastian Bohm , Tarun Khurana , Helmy A. Eltoukhy , Jian Gong
CPC classification number: C12Q1/6874 , B01L3/502792 , B01L2200/0673 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0851 , B01L2300/165 , B01L2400/0427
Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.
Abstract translation: 提供了用于使用液滴操纵进行排序的方法和装置，例如通过基于电润湿的技术。 还提供了用于在同一装置上进行样品制备和测序的综合方法和装置。 此外，提供了减少试剂废物的方法和包括用于样品制备和/或测序的试剂的预装的消耗品筒。
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3.发明申请SYSTEMS AND METHODS OF LOADING OR REMOVING LIQUIDS USED IN BIOCHEMICAL ANALYSIS 有权用于生物化学分析的装载或去除液体的系统和方法公开(公告)号：US20150352544A1
公开(公告)日：2015-12-10
申请号：US14712409
申请日：2015-05-14
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , Sebastian Bohm , Alexander Hsiao
IPC: B01L3/00
CPC classification number: B01L3/0289 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0673 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0487 , Y10T436/11
Abstract: System configured to conduct designated reactions for biological or chemical analysis. The system includes a liquid-exchange assembly comprising an assay reservoir for holding a first liquid, a receiving cavity for holding a second liquid that is immiscible with respect to the first liquid, and an exchange port fluidically connecting the assay reservoir and the receiving cavity. The system also includes a pressure activator that is operably coupled to the assay reservoir of the liquid-exchange assembly. The pressure activator is configured to repeatedly exchange the first and second liquids by (a) flowing a designated volume of the first liquid through the exchange port into the receiving cavity and (b) flowing a designated volume of the second liquid through the exchange port into the assay reservoir. The system also includes a fluidic system that is in flow communication with the liquid-exchange assembly.
Abstract translation: 系统配置为进行生物或化学分析的指定反应。 该系统包括液体交换组件，其包括用于保持第一液体的测定储存器，用于保持与第一液体不混溶的第二液体的接收腔以及流体连接测定储存器和接收腔的交换口。 该系统还包括可操作地耦合到液体交换组件的测定储存器的压力激活器。 压力启动器被配置为通过以下步骤来重复地交换第一和第二液体：（a）将指定体积的第一液体通过交换口流动到接收腔中，和（b）使指定体积的第二液体通过交换口流入 测定池。 该系统还包括与液体交换组件流动连通的流体系统。
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公开(公告)号：US20140073514A1
公开(公告)日：2014-03-13
申请号：US14084355
申请日：2013-11-19
Applicant: ILLUMINA, INC.
Inventor： Min-Jui Richard Shen , Robert C. Kain , Kenneth M. Kuhn , AmirAli Hajhossein Talasaz , Arash Jamshidi , George Sakaldasis , Eric Vermaas , Sebastian Bohm , Tarun Khurana , Helmy A. Eltoukhy , Jian Gong
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , B01L3/502792 , B01L2200/0673 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0851 , B01L2300/165 , B01L2400/0427
Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.
Abstract translation: 提供了用于使用液滴操纵进行排序的方法和装置，例如通过基于电润湿的技术。 还提供了用于在同一装置上进行样品制备和测序的综合方法和装置。 此外，提供了减少试剂废物的方法和包括用于样品制备和/或测序的试剂的预装的消耗品筒。
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公开(公告)号：US20130116128A1
公开(公告)日：2013-05-09
申请号：US13670318
申请日：2012-11-06
Applicant: ILLUMINA, INC.
Inventor： Min-Jui Richard Shen , Robert C. Kain , Kenneth M. Kuhn , AmirAli Hajhossein Talasaz , Arash Jamshidi , George Sakaldasis , Eric Vermaas , Sebastian Bohm , Tarun Khurana , Helmy A. Eltoukhy , Jian Gong
CPC classification number: C12Q1/6874 , B01L3/502792 , B01L2200/0673 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0851 , B01L2300/165 , B01L2400/0427
Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.
Abstract translation: 提供了用于使用液滴操纵进行排序的方法和装置，例如通过基于电润湿的技术。 还提供了用于在同一装置上进行样品制备和测序的综合方法和装置。 此外，提供了减少试剂废物的方法和包括用于样品制备和/或测序的试剂的预装的消耗品筒。
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240001361A1
公开(公告)日：2024-01-04
申请号：US18369587
申请日：2023-09-18
Applicant: ILLUMINA, INC.
Inventor： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Kumar Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
IPC: B01L3/00 , B01L7/00 , F16K99/00 , G01N35/08 , C12Q1/6869
CPC classification number: B01L3/502738 , B01L3/50273 , B01L7/52 , F16K99/0013 , F16K99/0028 , F16K99/0015 , G01N35/08 , B01L3/502715 , C12Q1/6869 , B01L2400/0644 , B01L2200/10 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , F16K2099/0084 , B01L2400/0655
Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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公开(公告)号：US10167505B2
公开(公告)日：2019-01-01
申请号：US15067013
申请日：2016-03-10
Applicant: Illumina, Inc.
Inventor： Min-Jui Richard Shen , Robert C. Kain , Kenneth M. Kuhn , AmirAli Hajhossein Talasaz , Arash Jamshidi , George Sakaldasis , Eric Vermaas , Sebastian Bohm , Tarun Khurana , Helmy A. Eltoukhy , Jian Gong
IPC: C12Q1/68 , B01L3/00 , C12Q1/6874 , B81B7/00
Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.
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8.发明申请公开(公告)号：US20200206737A1
公开(公告)日：2020-07-02
申请号：US16818953
申请日：2020-03-13
Applicant: Illumina, Inc.
Inventor： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
IPC: B01L3/00 , F16K99/00 , C12Q1/6869 , B01L7/00 , G01N35/08
Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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公开(公告)号：US09782770B2
公开(公告)日：2017-10-10
申请号：US14712409
申请日：2015-05-14
Applicant: ILLUMINA, INC.
Inventor： Dale Buermann , Sebastian Bohm , Alexander Hsiao
CPC classification number: B01L3/0289 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0673 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0487 , Y10T436/11
Abstract: System configured to conduct designated reactions for biological or chemical analysis. The system includes a liquid-exchange assembly comprising an assay reservoir for holding a first liquid, a receiving cavity for holding a second liquid that is immiscible with respect to the first liquid, and an exchange port fluidically connecting the assay reservoir and the receiving cavity. The system also includes a pressure activator that is operably coupled to the assay reservoir of the liquid-exchange assembly. The pressure activator is configured to repeatedly exchange the first and second liquids by (a) flowing a designated volume of the first liquid through the exchange port into the receiving cavity and (b) flowing a designated volume of the second liquid through the exchange port into the assay reservoir. The system also includes a fluidic system that is in flow communication with the liquid-exchange assembly.
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10.发明申请公开(公告)号：US20170144155A1
公开(公告)日：2017-05-25
申请号：US15315638
申请日：2015-06-03
Applicant: ILLUMINA, INC.
Inventor： Sebastian Bohm , Alex Aravanis , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Hai Quang Tran , Majid Aghababazadeh , M. Shane Bowen , Boyan Boyanov , Dale Buermann
Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.
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