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公开(公告)号：US10576471B2
公开(公告)日：2020-03-03
申请号：US15559321
申请日：2016-03-18
Applicant: ILLUMINA, Inc.
Inventor： James Osmus , Richard L. Lemoine , Jian Gong , Sz-Chin Steven Lin
IPC: B01L3/00
Abstract: Disclosed herein are devices, systems and methods for conducting a reaction using electrowetting in a vertical or substantially vertical position. Some embodiments disclosed herein provide fluidic cartridges for use in a substantially vertical position comprising: (a) a front substrate; (b) a back substrate; (c) a droplet operations gap formed between the front substrate and the back substrate; and (d) a plurality of electrodes on the front substrate or the back substrate, wherein the plurality of electrodes are configured to transport a droplet along a substantially vertical plane defined by the front substrate and the back substrate.
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公开(公告)号：US20180117587A1
公开(公告)日：2018-05-03
申请号：US15729729
申请日：2017-10-11
Applicant: ILLUMINA, INC. , ILLUMINA, SINGAPORE PTE. LTD.
Inventor： Richard L. Lemoine , James Osmus , Sz-Chin Steven Lin , Beng Keong ANG
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/02 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/16 , B01L2300/042 , B01L2300/0609 , B01L2300/0672 , B01L2300/0829 , B01L2400/0478 , B01L2400/0644 , F04B19/006 , G01N21/01 , G01N21/75
Abstract: A cartridge assembly that comprises a housing, including a flow cell chamber to receive a flow cell, and a well plate having liquid wells to receive desired amounts of liquids. The well plate includes a valve station, a pump station and a fluidics analysis station, and channels associated therewith. A pump assembly to manage fluid flow through the channels between the pump station and the fluidics analysis station. A rotary valve assembly that includes a rotor shaft and rotor valve positioned to rotate about a rotational axis and to selectively couple the wells to the pump station. The rotor shaft includes a dual spline configuration at the distal end thereof. The dual spline configuration has first and second sets of splines. The first set of splines forms a drive interface and the second set of splines forms a position encoding interface.
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公开(公告)号：US20220387998A1
公开(公告)日：2022-12-08
申请号：US17888318
申请日：2022-08-15
Applicant: ILLUMINA, INC. , ILLUMINA SINGAPORE PTE. LTD.
Inventor： Richard L. Lemoine , James Osmus , Sz-Chin Steven Lin , Beng Keong Ang
Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.
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公开(公告)号：US20220280940A1
公开(公告)日：2022-09-08
申请号：US17750610
申请日：2022-05-23
Applicant: ILLUMINA, INC.
Inventor： Sz-Chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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公开(公告)号：US11351541B2
公开(公告)日：2022-06-07
申请号：US16500787
申请日：2018-04-02
Applicant: ILLUMINA, INC.
Inventor： Sz-Chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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Patent Agency Ranking
公开(公告)号：US11458469B2
公开(公告)日：2022-10-04
申请号：US16443727
申请日：2019-06-17
Applicant: ILLUMINA, INC. , ILLUMINA SINGAPORE PTE. LTD.
Inventor： Richard L. Lemoine , James Osmus , Sz-Chin Steven Lin , Beng Keong Ang
Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.
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公开(公告)号：US11426723B2
公开(公告)日：2022-08-30
申请号：US16584353
申请日：2019-09-26
Applicant: Illumina, Inc.
Inventor： Wesley A. Cox-Muranami , Kay Klausing , Bradley Kent Drews , Nicholas Watson , Jennifer Olivia Foley , Murphy Hitchcock , Paul Sangiorgio , Sz-Chin Steven Lin
IPC: B01L3/00
Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.
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公开(公告)号：US10343160B2
公开(公告)日：2019-07-09
申请号：US15729729
申请日：2017-10-11
Applicant: ILLUMINA, INC. , ILLUMINA, SINGAPORE PTE. LTD.
Inventor： Richard L. Lemoine , James Osmus , Sz-Chin Steven Lin , Beng Keong Ang
Abstract: A cartridge assembly that comprises a housing, including a flow cell chamber to receive a flow cell, and a well plate having liquid wells to receive desired amounts of liquids. The well plate includes a valve station, a pump station and a fluidics analysis station, and channels associated therewith. A pump assembly to manage fluid flow through the channels between the pump station and the fluidics analysis station. A rotary valve assembly that includes a rotor shaft and rotor valve positioned to rotate about a rotational axis and to selectively couple the wells to the pump station. The rotor shaft includes a dual spline configuration at the distal end thereof. The dual spline configuration has first and second sets of splines. The first set of splines forms a drive interface and the second set of splines forms a position encoding interface.
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公开(公告)号：US12011713B2
公开(公告)日：2024-06-18
申请号：US17817204
申请日：2022-08-03
Applicant: Illumina, Inc.
Inventor： Wesley A. Cox-Muranami , Kay Klausing , Bradley Kent Drews , Nicholas Watson , Jennifer Olivia Foley , Murphy Hitchcock , Paul Sangiorgio , Sz-Chin Steven Lin
IPC: B01L3/00
CPC classification number: B01L3/502 , B01L2200/141 , B01L2200/16 , B01L2300/047 , B01L2300/06 , B01L2400/0487 , B01L2400/0644
Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.
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公开(公告)号：US11724258B2
公开(公告)日：2023-08-15
申请号：US17750610
申请日：2022-05-23
Applicant: ILLUMINA, INC.
Inventor： Sz-Chin Steven Lin , Richard Lemoine , Rajagopal Panchapakesan , Wesley A. Cox-Muranami , Darren Segale
CPC classification number: B01L3/502738 , F16K99/0013 , F16K99/0028 , G01M3/26 , G01M3/2876 , B01L2400/0644 , F16K2099/0084
Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.
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