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公开(公告)号：US11243390B2
公开(公告)日：2022-02-08
申请号：US17110406
申请日：2020-12-03
Applicant: ILLUMINA, INC.
Inventor： Austin Corbett , Bo Lu , Robert Langlois , Joseph Pinto , Yu Chen , Peter Newman , Hongji Ren
Abstract: A method is used to generate a report presenting parameter values corresponding to a structured illumination microscopy (SIM) optical system. The parameter values are based at least in part on the performed modulation calculation corresponding to an image set captured with the SIM optical system. A minimum FWHM slice is identified, based at least in part on an average FWHM value across the images in the first image set. Parameter estimation is performed on the identified minimum FWHM slice. Best in-focus parameters are identified based at least in part on the performed estimation. A phase estimate is performed for each image in the set. A modulation calculation is performed based at least in part on the identified best in-focus parameters. The report is based at least in part on the performed modulation calculation.
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公开(公告)号：US11885953B2
公开(公告)日：2024-01-30
申请号：US17558829
申请日：2021-12-22
Applicant: ILLUMINA, INC.
Inventor： Austin Corbett , Bo Lu , Robert Langlois , Joseph Pinto , Yu Chen , Peter Newman , Hongji Ren
CPC classification number: G02B21/365 , G02B26/06 , G06T7/0014 , G06T7/80 , H04N23/56 , G02B21/082 , G06T2207/10056 , G06T2207/30168
Abstract: A method is used to generate a report presenting parameter values corresponding to a structured illumination microscopy (SIM) optical system. The parameter values are based at least in part on the performed modulation calculation corresponding to an image set captured with the SIM optical system. A minimum FWHM slice is identified, based at least in part on an average FWHM value across the images in the first image set. Parameter estimation is performed on the identified minimum FWHM slice. Best in-focus parameters are identified based at least in part on the performed estimation. A phase estimate is performed for each image in the set. A modulation calculation is performed based at least in part on the identified best in-focus parameters. The report is based at least in part on the performed modulation calculation.
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公开(公告)号：US20210173194A1
公开(公告)日：2021-06-10
申请号：US17110406
申请日：2020-12-03
Applicant: ILLUMINA, INC.
Inventor： Austin Corbett , Bo Lu , Robert Langlois , Joseph Pinto , Yu Chen , Peter Newman , Hongji Ren
Abstract: A method is used to generate a report presenting parameter values corresponding to a structured illumination microscopy (SIM) optical system. The parameter values are based at least in part on the performed modulation calculation corresponding to an image set captured with the SIM optical system. A minimum FWHM slice is identified, based at least in part on an average FWHM value across the images in the first image set. Parameter estimation is performed on the identified minimum FWHM slice. Best in-focus parameters are identified based at least in part on the performed estimation. A phase estimate is performed for each image in the set. A modulation calculation is performed based at least in part on the identified best in-focus parameters. The report is based at least in part on the performed modulation calculation.
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Patent Agency Ranking
公开(公告)号：US20250004244A1
公开(公告)日：2025-01-02
申请号：US18759291
申请日：2024-06-28
Applicant: ILLUMINA, INC.
Inventor： Dustin Blair , Gregory Holst , Merek Siu , Paul Sangiorgio , Dakota Watson , Danilo Condello , John Earney , Peter Newman
Abstract: An imaging system includes a focus tracking module including: a light source to project a first pair of spots on a sample; and a first image sensor to obtain one or more first images of the first pair of spots; a second image sensor to obtain one or more second images of the sample; one or more mirrors optically coupled to the second image sensor, the one or more mirrors positioned in an optical path from the sample to the second image sensor; and a controller to: determine, using at least a first separation distance measurement of the first pair of spots from the one or more first images, a first sample tilt of the sample about a first axis of the imaging system; and actuate, based at least on the first sample tilt, the one or more mirrors to offset the first sample tilt about the first axis.
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公开(公告)号：US20240369469A1
公开(公告)日：2024-11-07
申请号：US18652880
申请日：2024-05-02
Applicant: ILLUMINA, INC.
Inventor： Dakota Watson , Joseph Pinto , Peter Newman
IPC: G01N15/1434
Abstract: An apparatus includes a sample stage region, an optical assembly, and a camera assembly. The optical assembly includes an objective element, a tube lens, and a compensating element. The objective element provides a field of view. at least a portion of the sample stage region is within the field of view. The objective element has a variable astigmatism. The tube lens is configured to receive light transmitted through the objective element and further transmit the light through an image space. The compensating element is in the image space. The compensating element is configured to induce a second astigmatism. The second astigmatism is configured to offset the variable astigmatism. The camera assembly is configured to receive light transmitted from the compensating assembly.
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公开(公告)号：US20220113532A1
公开(公告)日：2022-04-14
申请号：US17558829
申请日：2021-12-22
Applicant: ILLUMINA, INC.
Inventor： Austin Corbett , Bo Lu , Robert Langlois , Joseph Pinto , Yu Chen , Peter Newman , Hongji Ren
Abstract: A method is used to generate a report presenting parameter values corresponding to a structured illumination microscopy (SIM) optical system. The parameter values are based at least in part on the performed modulation calculation corresponding to an image set captured with the SIM optical system. A minimum FWHM slice is identified, based at least in part on an average FWHM value across the images in the first image set. Parameter estimation is performed on the identified minimum FWHM slice. Best in-focus parameters are identified based at least in part on the performed estimation. A phase estimate is performed for each image in the set. A modulation calculation is performed based at least in part on the identified best in-focus parameters. The report is based at least in part on the performed modulation calculation.
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公开(公告)号：US20240348906A1
公开(公告)日：2024-10-17
申请号：US18750675
申请日：2024-06-21
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Peter Newman , Matthew Hage , Geraint Evans
CPC classification number: H04N23/55 , G02B13/0095 , H04N23/54
Abstract: An apparatus and method for imaging includes an imaging system formed of a movable objective stage proximal to a sample and positioned for providing an excitation beam onto and for capturing an emission from the sample. The movable objective stage includes an optical lens apparatus and a turn reflector optically coupled to the imaging optics, where at least one of the optical lens apparatus and the turn reflector are movable relative to one another for scanning the sample, and wherein the movement is achieved while maintaining a substantially fixed optical path length between the optical lens apparatus and a fixed plane in a fixed imaging optics stage.
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公开(公告)号：US12063430B2
公开(公告)日：2024-08-13
申请号：US17957659
申请日：2022-09-30
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Peter Newman , Matthew Hage , Geraint Evans
CPC classification number: H04N23/55 , G02B13/0095 , H04N23/54
Abstract: An apparatus and method for imaging includes an imaging system formed of a movable objective stage proximal to a sample and positioned for providing an excitation beam onto and for capturing an emission from the sample. The movable objective stage includes an optical lens apparatus and a turn reflector optically coupled to the imaging optics, where at least one of the optical lens apparatus and the turn reflector are movable relative to one another for scanning the sample, and wherein the movement is achieved while maintaining a substantially fixed optical path length between the optical lens apparatus and a fixed plane in a fixed imaging optics stage.
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