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1.发明授权公开(公告)号：US11933728B2
公开(公告)日：2024-03-19
申请号：US18154405
申请日：2023-01-13
发明人： Gary Skinner , Geraint Evans , Stanley Hong
IPC分类号： G06V10/10 , B01L3/00 , G01N21/05 , G01N21/64 , G02B21/06 , G02B21/16 , G02B21/36 , G02B27/42
CPC分类号： G01N21/6452 , B01L3/5085 , G01N21/05 , G02B21/06 , G02B21/16 , G02B21/365 , G02B27/425 , G06V10/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/0893 , B01L2300/0896
摘要： Techniques are described for reducing the number of angles needed in structured illumination imaging of biological samples through the use of patterned flowcells, where nanowells of the patterned flowcells are arranged in, e.g., a square array, or an asymmetrical array. Accordingly, the number of images needed to resolve details of the biological samples is reduced. Techniques are also described for combining structured illumination imaging with line scanning using the patterned flowcells.
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公开(公告)号：US20220150394A1
公开(公告)日：2022-05-12
申请号：US17513042
申请日：2021-10-28
发明人： Geraint Evans , Stanley Hong , Merek Siu , Shaoping Lu , John Moon
摘要： A method is used to generate an analysis image of a moving sample based on one or more exposures. An illumination source illuminates a field of view of a camera for one or more pulses while the sample moves through the field of view. The distance moved by the sample during each of these one or more pulses may be less than the size of one pixel in an image captured by the camera.
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公开(公告)号：US20220331798A1
公开(公告)日：2022-10-20
申请号：US17854741
申请日：2022-06-30
发明人： Geraint Evans , Stanley S. Hong
摘要： For example, a flowcell includes: a nanowell layer having a first set of nanowells and a second set of nanowells to receive a sample; a first linear waveguide associated with the first set of nanowells, and a second linear waveguide associated with the second set of nanowells; and a first grating for the first linear waveguide, and a second grating for the second linear waveguide, the first and second gratings providing differential coupling of first light and second light.
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公开(公告)号：US11406977B2
公开(公告)日：2022-08-09
申请号：US17255765
申请日：2020-05-19
发明人： Geraint Evans , Stanley S. Hong
IPC分类号： B01L3/00 , G02B27/42 , G01N21/05 , C12Q1/6869 , G01N21/64
摘要： For example, a flowcell includes: a nanowell layer having a first set of nanowells and a second set of nanowells to receive a sample; a first linear waveguide associated with the first set of nanowells, and a second linear waveguide associated with the second set of nanowells; and a first grating for the first linear waveguide, and a second grating for the second linear waveguide, the first and second gratings providing differential coupling of first light and second light.
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公开(公告)号：US20220134334A1
公开(公告)日：2022-05-05
申请号：US17310790
申请日：2020-12-08
发明人： Geraint Evans , Stanley Hong
摘要： An analysis substrate comprises: a localization layer to be provided with a sample comprising a nucleotide provided with a fluorescent dye; and a sensor layer comprising an array of sensor pixels, the localization layer being on-chip relative to the sensor layer, one or more of the array of sensor pixels to receive a propagation of fluorescence from the fluorescent dye.
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公开(公告)号：US12053776B2
公开(公告)日：2024-08-06
申请号：US17854741
申请日：2022-06-30
发明人： Geraint Evans , Stanley S. Hong
IPC分类号： G01N21/05 , B01L3/00 , C12Q1/6869 , G01N21/64 , G02B27/42
CPC分类号： B01L3/502715 , G01N21/05 , G02B27/4227 , B01L2300/0829 , B01L2300/0861 , B01L2300/0896 , C12Q1/6869 , G01N2021/6482
摘要： For example, a flowcell includes: a nanowell layer having a first set of nanowells and a second set of nanowells to receive a sample; a first linear waveguide associated with the first set of nanowells, and a second linear waveguide associated with the second set of nanowells; and a first grating for the first linear waveguide, and a second grating for the second linear waveguide, the first and second gratings providing differential coupling of first light and second light.
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公开(公告)号：US20230272837A1
公开(公告)日：2023-08-31
申请号：US18113815
申请日：2023-02-24
发明人： Gregory Holst , Dustin Blair , John Earney , Geraint Evans , Matthew Hage
IPC分类号： F16F15/03
CPC分类号： F16F15/035 , F16F2230/0047
摘要： An apparatus includes a chassis, a frame, a sample support member, an imaging assembly, an actuation assembly, and a vibration capture assembly. The frame is coupled with the chassis. The sample support member is supported by the frame. The actuation assembly is supported by the frame and is operable to drive movement of the imaging assembly relative to the sample support member. The vibration capture assembly is operable to selectively transition between a plurality of modes, including a damping mode and an isolation mode. In the damping mode, the vibration capture assembly is configured to resist movement of the frame relative to the chassis in response to operation of the actuation assembly. In the isolation mode, the vibration capture assembly is configured to prevent transmission of vibrational movement in the chassis to the frame.
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公开(公告)号：US20220333178A1
公开(公告)日：2022-10-20
申请号：US17699573
申请日：2022-03-21
发明人： Gary Mark Skinner , Geraint Evans , Niall Gormley , Jonathan Boutell , Matthew W. Kellinger , Michael Previte , Molly He
IPC分类号： C12Q1/6848 , C12Q1/70
摘要： A method for seeding and amplifying target nucleic acids derived from a sample in a cluster at a site on a surface of a substrate includes retaining at least a portion of the target nucleic acids in an inactive form that cannot seed to provide a relatively low concentration of active form target nucleic acids available for seeding. As the active form target nucleic acids seed on the surface of the substrate, they may be amplified. Because the concentration of active form target nucleic acids is low, the likelihood is low that a second active form target nucleic acid will seed at the same site within the same cluster before the first active form target nucleic acid is sufficiently amplified to dominate. Accordingly, the likelihood that the cluster will pass filters is increased relative to traditional seeding and amplification methods employing a higher concentration of active form target nucleic acids.
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公开(公告)号：US20220105511A1
公开(公告)日：2022-04-07
申请号：US17255765
申请日：2020-05-19
发明人： Geraint Evans , Stanley S. Hong
摘要： For example, a flowcell includes: a nanowell layer having a first set of nanowells and a second set of nanowells to receive a sample; a first linear waveguide associated with the first set of nanowells, and a second linear waveguide associated with the second set of nanowells; and a first grating for the first linear waveguide, and a second grating for the second linear waveguide, the first and second gratings providing differential coupling of first light and second light.
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公开(公告)号：US20240348906A1
公开(公告)日：2024-10-17
申请号：US18750675
申请日：2024-06-21
申请人： ILLUMINA, INC.
发明人： Steven Boege , Simon Prince , Peter Newman , Matthew Hage , Geraint Evans
CPC分类号： H04N23/55 , G02B13/0095 , H04N23/54
摘要： An apparatus and method for imaging includes an imaging system formed of a movable objective stage proximal to a sample and positioned for providing an excitation beam onto and for capturing an emission from the sample. The movable objective stage includes an optical lens apparatus and a turn reflector optically coupled to the imaging optics, where at least one of the optical lens apparatus and the turn reflector are movable relative to one another for scanning the sample, and wherein the movement is achieved while maintaining a substantially fixed optical path length between the optical lens apparatus and a fixed plane in a fixed imaging optics stage.
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