公开(公告)号：US20210017595A1

公开(公告)日：2021-01-21

申请号：US17040036

申请日：2019-03-22

Applicant: IMEC VZW

Inventor： Tim STAKENBORG ,  Chang CHEN ,  Kris COVENS ,  Qing CAI ,  Maarten FAUVART

IPC: C12Q1/6869 ,  G06N3/12 ,  G16B50/00

Abstract: The present invention relates to a method for writing data comprising a sequence of bits, the data being written in a form of nucleic acid, by in-vitro enzymatically producing memory nucleic acid from a strand of memory writing substrate nucleic acid, wherein the strand of memory writing substrate nucleic acid comprises a plurality of spacer sections and memory writing sections sandwiched between the spacer sections. Each of the spacer sections comprises one or more nucleobases, and each of the memory writing sections comprises a nucleobase other than the nucleobases of an adjacent spacer section upstream of the memory writing section in a travel direction of an enzyme along the strand of memory writing substrate nucleic acid. The method comprising: repeating of: synthesising, in liquid medium comprising the strand of memory writing substrate nucleic acid contacted with the enzyme, a spacer portion of the memory nucleic acid from a spacer section by the enzyme by contacting with a solution of spacer nucleotides compatible with the nucleobases of the spacer section; halting the synthesising of the spacer portion in a position where the enzyme is reaching the memory writing section resulting from incompatibility between spacer nucleotides and nucleobases of the portion of the memory nucleic acid from the memory writing section; receiving a sub-sequence of the sequence of bits, said sub-sequence comprising at least one bit; selecting a memory nucleotide compatible with the nucleobase of the memory writing section, and comprising a first label or first modification, on a condition that said sub-sequence comprises a predetermined first sequence of bit-values, and selecting a memory nucleotide compatible with the nucleobase of the memory writing section, and comprising a second label or second modification, on a condition that said sub-sequence comprises a predetermined second sequence of bit-values; and subsequent to the halting, synthesising, in the liquid medium comprising the strand of memory writing substrate nucleic acid contacted with the enzyme, a memory portion of the memory nucleic acid from the memory writing section by the enzyme by contacting the enzyme with a solution of the selected memory nucleotide.

公开(公告)号：US20240165622A1

公开(公告)日：2024-05-23

申请号：US18509500

申请日：2023-11-15

Applicant: IMEC VZW

Inventor： Olivier HENRY ,  Tim STAKENBORG ,  Willem VAN ROY ,  Peter PEUMANS

IPC: B01L3/00 ,  G01N15/14

CPC classification number: B01L3/502761 ,  B01L3/502776 ,  B01L3/502792 ,  G01N15/1484 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2200/10 ,  B01L2400/0403 ,  G01N2015/1445

Abstract: A method for monitoring a monitor material of a process, such as a manufacturing process, comprises: detecting a suspicious particle in a sample of the monitor material using an imaging system configured to image the sample using illumination light from a light source and to detect an interference pattern based on object light having interacted with the sample and reference light of the illumination light; selectively diverting the suspicious particle rom a flow of the sample to an analysis flow; activating a nucleic acid test (NAT) device, wherein said activating is triggered based on detecting of the suspicious particle in the sample; receiving by the NAT device the analysis flow comprising the suspicious particle; and subjecting the suspicious particle to a NAT analysis.
Also, an apparatus for monitoring a monitor material is provided.

公开(公告)号：US20240207845A1

公开(公告)日：2024-06-27

申请号：US18389977

申请日：2023-12-20

Applicant: IMEC VZW

Inventor： Lei ZHANG ,  Simone SEVERI ,  Riet LABIE ,  Philippe SOUSSAN ,  Tim STAKENBORG ,  Gauri KARVE

IPC: B01L3/00 ,  B81B7/00 ,  B81C1/00

CPC classification number: B01L3/502715 ,  B81B7/008 ,  B81C1/00238 ,  B01L2200/04 ,  B01L2300/0645 ,  B01L2300/168 ,  B81B2201/05 ,  B81B2203/0338 ,  B81B2207/07 ,  B81C2203/0792

Abstract: According to an aspect of the present inventive concept there is provided a microfluidic device comprising: at least one structure arranged in a pocket-defining layer defining a pocket in the pocket-defining layer; a semiconductor chip arranged in the pocket, the semiconductor chip comprising at least one electrode at the surface of the semiconductor chip; an electrical connection layer arranged above the semiconductor chip, wherein the electrical connection layer comprises electronic connections electrically connected to the at least one electrode and arranged to extend laterally in the electrical connection layer away from the semiconductor chip; at least one fluidic channel extending through the pocket-defining layer and above the semiconductor chip, the fluidic channel being arranged to be in fluidic communication with the at least one electrode.

公开(公告)号：US20180169653A1

公开(公告)日：2018-06-21

申请号：US15899982

申请日：2018-02-20

Applicant: PANASONIC CORPORATION ,  IMEC VZW

Inventor： Shuji SATO ,  Yasuaki OKUMURA ,  Yukari NISHIYAMA ,  Tatsurou KAWAMURA ,  Ben JONES ,  Liesbet LAGAE ,  Tim STAKENBORG

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2300/041 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0861 ,  B01L2400/0406 ,  B01L2400/0688 ,  G01N21/03 ,  G01N27/416 ,  G01N33/54386

Abstract: A micro analysis chip comprises an inlet and a fluid flow path communicating thereto. The fluid flow path comprises a first flow path, a second flow path, and a third flow path arranged continuously along a longitudinal direction of the fluid flow path. An antibody is bound on at least one peripheral surface selected from the group consisting of peripheral surfaces of the second and third flow paths. A cross-sectional area of the third flow path is constant or increased monotonically along a direction X from the second flow path toward the third flow path. A cross-sectional area of the second flow path is increased monotonically along the direction X from the one end to the other end of the second flow path. A cross-sectional area of the first flow path is larger than a cross-sectional area at the one end of the second flow path.