公开(公告)号：US20210102177A1

公开(公告)日：2021-04-08

申请号：US17119484

申请日：2020-12-11

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Karl Russell Koehler ,  Jiyoon Lee

IPC: C12N5/071 ,  A61L27/60 ,  A61L27/38 ,  A61K35/36 ,  C12N5/077 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C12Q1/6876

Abstract: Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.

公开(公告)号：US20180305671A1

公开(公告)日：2018-10-25

申请号：US15769139

申请日：2016-10-21

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Karl R. Koehler ,  Jiyoon Lee

IPC: C12N5/071 ,  A61L27/52 ,  A61L27/56 ,  A61L27/54 ,  A61L27/58 ,  C12Q1/6876 ,  A61L27/38 ,  A61L27/36 ,  A61L27/60

CPC classification number: C12N5/0698 ,  A61K35/36 ,  A61L27/362 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/3895 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2430/34 ,  A61L2430/40 ,  C12N5/0606 ,  C12N5/0629 ,  C12N2501/155 ,  C12N2501/999 ,  C12N2506/03 ,  C12N2506/1346 ,  C12N2513/00 ,  C12N2533/76 ,  C12Q1/6876 ,  C12Q2600/136

Abstract: Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.

公开(公告)号：US11021688B2

公开(公告)日：2021-06-01

申请号：US15769139

申请日：2016-10-21

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Karl R. Koehler ,  Jiyoon Lee

IPC: C12N5/071 ,  A61L27/60 ,  A61L27/38 ,  A61K35/36 ,  C12N5/077 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C12Q1/6876

Abstract: Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.