-
公开(公告)号：US20180153962A1
公开(公告)日：2018-06-07
申请号：US15576027
申请日：2016-05-20
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： Thierry LEVEILLARD , John FLANNERY , Mei XIN , Leah BYRNE , José-Alain SAHEL , Emmanuelle CLERIN-LACHAPELLE , Sun JUNWEI , Jean BENNETT , Jeannette BENNICELLI
摘要： The present invention relates to the synergistic combination of the short and long Rod-Derived Cone Viability Factors and to methods for treating retinal degenerative diseases.
-
2.发明公开公开(公告)号：US20230159609A1
公开(公告)日：2023-05-25
申请号：US17995880
申请日：2020-07-10
申请人： Sorbonne Université , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale) , Ruhr-Universität Bochum , Centrre Hospitalier National d'Ophtalmologie Quinze-Vingts
发明人： Deniz DALKARA , Cardillia-Joe SIMON , Stefan HERLITZE , José-Alain SAHEL , Isabelle AUDO , Serge PICAUD , Stéphane Bertin
IPC分类号： C07K14/705 , C12N15/86 , C07K14/005 , A61P27/02 , A61P25/00
CPC分类号： C07K14/705 , C12N15/86 , C07K14/005 , A61P27/02 , A61P25/00 , C12N2750/14143 , C12N2750/14145 , C12N2750/14171 , C12N2750/14122 , A61K48/00
摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones.
-
3.发明公开公开(公告)号：US20230330440A1
公开(公告)日：2023-10-19
申请号：US18044645
申请日：2021-09-09
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Serge PICAUD , Sara CADONI , José-Alain SAHEL , Mickaël TANTER , Charlie DEMENE
CPC分类号： A61N7/00 , C12N15/86 , A61N2007/0026 , C12N2750/14143 , A61N2007/0095
摘要： Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.
-
4.发明公开公开(公告)号：US20230172919A1
公开(公告)日：2023-06-08
申请号：US17913268
申请日：2021-03-26
申请人： SORBONNE UNIVERSITE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61K31/4439 , A61K9/00 , A61P27/02 , A61K45/06 , A61K31/155
CPC分类号： A61K31/4439 , A61K9/0019 , A61K9/0048 , A61K31/155 , A61K45/06 , A61P27/02
摘要： An insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment, and in particular for preventing or treating the loss of vision induced by retinal detachment. Also, a composition including the insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment and a device including the composition.
-
公开(公告)号：US20190225649A1
公开(公告)日：2019-07-25
申请号：US16300438
申请日：2017-05-10
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
摘要： Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.
-
公开(公告)号：US20190010235A1
公开(公告)日：2019-01-10
申请号：US16066015
申请日：2016-12-23
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (Institut National de la Santé et de la Recherche Médicale)
摘要： Disclosed are agents inhibiting the interaction between CFH and CD11b/18, as well as the use of such agents, in particular for treating inflammatory disorders, such as age-related macular degeneration.
-
公开(公告)号：US20180353482A1
公开(公告)日：2018-12-13
申请号：US15777078
申请日：2016-11-17
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Valérie FONTAINE , Cécile VIDAL , José-Alain SAHEL
IPC分类号： A61K31/426 , A61P27/02 , A61K9/00
CPC分类号： A61K31/426 , A61K9/0048 , A61K9/0053 , A61P27/02
摘要： Disclosed is a method utilizing (R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or an analogue, pharmaceutically acceptable salt or solvate thereof for the treatment of a retinal disease, more specifically using mirabegron for the treatment of age-related macular degeneration. Also Disclosed is a pharmaceutical composition, a medicament and a kit for the treatment of age-related macular degeneration.
-
8.发明申请METHODS FOR OBTAINING RETINAL PROGENITORS, RETINAL PIGMENTED EPITHELIAL CELLS AND NEURAL RETINAL CELLS 有权用于获得终末前列腺素，上皮细胞上皮细胞和神经细胞的方法公开(公告)号：US20160060596A1
公开(公告)日：2016-03-03
申请号：US14786427
申请日：2014-04-25
申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
IPC分类号： C12N5/079 , C12N5/0793 , C12N5/0797
CPC分类号： C12N5/0621 , C12N5/062 , C12N5/0623 , C12N2501/115 , C12N2501/42 , C12N2502/1323 , C12N2506/03 , C12N2527/00 , C12N2533/54
摘要： A method for in vitro obtaining human retinal progenitors, includes the steps of (i) placing an adherent culture of human pluripotent stem cells in a pro-neural medium; and (ii) maintaining this culture in the pro-neural medium until the appearance of pigmented cells and/or of neuroepithelial-like structures. Additional steps can be performed to obtain RPE cells and/or precursors of the neural retina.
摘要翻译： 体外获得人视网膜祖细胞的方法包括以下步骤：（i）将人多能干细胞的贴壁培养物置于前神经培养基中; 和（ii）将该培养物保持在前神经培养基中，直到着色细胞和/或神经上皮样结构的出现。 可以进行附加步骤以获得神经视网膜的RPE细胞和/或前体。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.061 秒)
