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公开(公告)号：US20180022790A1
公开(公告)日：2018-01-25
申请号：US15547379
申请日：2016-01-28
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , A61K39/12 , A61K39/395 , A61K39/39516 , A61K39/42 , A61K2039/505 , A61K2039/5258 , A61K2039/545 , C07K16/00 , C07K2317/20 , C07K2317/76 , C12N7/00 , C12N2760/14022 , C12N2760/14034 , C12N2760/14122 , C12N2760/14134 , C12N2760/14222 , C12N2760/14234
摘要： The disclosure provides a composition comprising immunoglobulin from an equine that has been hyper-immunized with a filovirus immunogen. The disclosure further provides methods of making such compositions and methods of using such compositions, e.g., for treating Ebola virus infection.
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2.发明申请公开(公告)号：US20200040065A1
公开(公告)日：2020-02-06
申请号：US16340996
申请日：2017-10-09
摘要： This disclosure provides a method for preventing, treating, or managing an ebolavirus infection in a subject, where the method includes administering to a subject in need thereof an effective amount of at least one pan-ebolavirus internal fusion loop antibody or antigen-binding fragment thereof, wherein the binding domain specifically binds to the epitope on two or more ebolavirus species or strains.
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3.发明申请TARGETING IMMUNOLOGICAL FUNCTIONS TO THE SITE OF BACTERIAL INFECTIONS USING CELL WALL TARGETING DOMAINS OF BACTERIOLYSINS 审中-公开使用细胞壁定向细菌菌株领域的细菌感染领域的免疫功能公开(公告)号：US20160333077A1
公开(公告)日：2016-11-17
申请号：US15111383
申请日：2015-01-14
CPC分类号： C07K16/1271 , A61K38/00 , C07K14/195 , C07K2317/24 , C07K2317/76 , C07K2319/00 , C07K2319/70 , C12N9/52 , C12Y304/24075
摘要： This disclosure provides a comprehensive approach to specifically target various immune functions to the site of infection by a variety of fusion proteins that consist of a bacteriocin cell wall targeting domain (CWT) and an immune function mediating component (IFMC). The CWT targets the fusion protein to the bacterial surface leading to accumulation at the site of infection. The IFMC mediates various immune functions such as toxin neutralization or recruitment of immune cells that can clear the bacteria.
摘要翻译： 本公开提供了通过由细菌素细胞壁靶向结构域（CWT）和免疫功能介导成分（IFMC）组成的多种融合蛋白来特异性靶向针对感染部位的各种免疫功能的综合方法。 CWT将融合蛋白靶向细菌表面，导致在感染部位积聚。 IFMC介导各种免疫功能，如毒素中和或能够清除细菌的免疫细胞的募集。
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公开(公告)号：US20190381162A1
公开(公告)日：2019-12-19
申请号：US16084151
申请日：2017-03-27
IPC分类号： A61K39/12 , C12N15/86 , C07K14/005
摘要： Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.
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5.发明申请公开(公告)号：US20170334973A1
公开(公告)日：2017-11-23
申请号：US15522357
申请日：2015-10-27
申请人： INTEGRATED BIOTHERAPEUTICS, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： Mohammad Javad AMAN , Frederick Wayne HOLTSBERG , Sven G. ENTERLEIN , Katie A. HOWELL , Zhen-Yong KECK , Steven K. H. FOUNG
IPC分类号： C07K16/10 , G01N33/569 , A61K39/00
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/56983 , G01N2333/08 , G01N2469/10
摘要： The disclosure provides non-human primate-derived binding molecules, e.g., antibodies or antigen-binding fragments thereof, that can bind to orthologous epitopes found on two or more filovirus species or strains.
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公开(公告)号：US20180141981A1
公开(公告)日：2018-05-24
申请号：US15541108
申请日：2016-01-06
IPC分类号： C07K14/31 , A61K47/64 , A61K47/61 , A61K39/085 , A61K39/02 , A61P31/04 , A61P11/00 , A61P37/06
CPC分类号： C07K14/31 , A61K39/02 , A61K39/085 , A61K47/61 , A61K47/646 , A61K2039/507 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/575 , A61P11/00 , A61P31/04 , A61P37/06 , C07K16/12 , C07K16/1271 , C07K2317/76 , C07K2319/21
摘要： The present disclosure provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present disclosure provides methods of inducing an immune response against an alpha-hemolysin-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.
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