公开(公告)号：US09995623B2

公开(公告)日：2018-06-12

申请号：US14775299

申请日：2013-12-03

Applicant: Integrated Plasmonics Corporation

Inventor： Robert Joseph Walters

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/10 ,  G01N21/25 ,  G01J3/12 ,  G01J3/18 ,  G01J3/42 ,  G01N21/31

CPC classification number: G01J3/0208 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0272 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/12 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/42 ,  G01J2003/1213 ,  G01N21/255 ,  G01N2021/3122

Abstract: A spectroscopic device, which may be a handheld spectroscopic light source, which uses ambient light as a primary broadband light source, but which may be supplemented with an auxiliary light source to supplement band regions which may be deficient in the broad band source. The spectroscopic device makes use of a number of parallel control channels to monitor for sufficient light and to compensate for variations in the input light levels.

公开(公告)号：US10241347B2

公开(公告)日：2019-03-26

申请号：US15694682

申请日：2017-09-01

Applicant: Integrated Plasmonics Corporation

Inventor： Michael Yagoda Shagam ,  Robert Joseph Walters

IPC: G01N21/00 ,  G02B27/46 ,  G01N21/25 ,  G01N21/31 ,  B23K26/384 ,  B23K26/402 ,  C23C14/34 ,  C25D5/02 ,  B23K103/18 ,  B23K103/00

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

公开(公告)号：US09784986B2

公开(公告)日：2017-10-10

申请号：US14774990

申请日：2013-12-03

Applicant: Integrated Plasmonics Corporation

Inventor： Michael Yagoda Shagam ,  Robert Joseph Walters

IPC: G01N21/00 ,  G02B27/46 ,  G01N21/25 ,  G01N21/31 ,  B23K26/384 ,  B23K26/402 ,  C23C14/34 ,  C25D5/02 ,  B23K103/18

CPC classification number: G02B27/46 ,  B23K26/384 ,  B23K26/402 ,  B23K2103/18 ,  B23K2103/50 ,  C23C14/34 ,  C25D5/02 ,  G01N21/255 ,  G01N21/31 ,  G01N2201/0633 ,  G01N2201/068

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

公开(公告)号：US09404797B2

公开(公告)日：2016-08-02

申请号：US14648843

申请日：2013-12-03

Applicant: Integrated Plasmonics Corporation

Inventor： Robert Joseph Walters

IPC: G01N21/25 ,  G01J3/02 ,  G01J3/42 ,  G02B5/00 ,  G01N21/64

CPC classification number: G01J3/0229 ,  G01J3/0208 ,  G01J3/42 ,  G01N21/64 ,  G02B5/008

Abstract: A spectroscopic measurement system, which may utilize multiple plasmonic filters associated with a cuvette to monitor different wavelengths of light. The spectroscopic measurement system may measure absorbance and or fluorescence, and may have built-in low cost CMOS image sensor(s). Reagents and samples may be introduced to the cuvette from a fluidics manifold. Multiple sets of combined cuvettes, image sensors and plasmonic filters may utilize a single fluidics manifold for reagent and sample distribution.

Abstract translation: 一种光谱测量系统，其可以利用与比色皿相关联的多个等离子体激元滤波器来监测不同波长的光。 光谱测量系统可以测量吸光度和/或荧光，并且可以具有内置的低成本CMOS图像传感器。 试剂和样品可以从流体歧管引入试管。 多套组合的比色皿，图像传感器和等离子体激元过滤器可以利用单个流体歧管进行试剂和样品分布。

公开(公告)号：US08582108B2

公开(公告)日：2013-11-12

申请号：US13717201

申请日：2012-12-17

Applicant: Integrated Plasmonics Corporation

Inventor： Robert Joseph Walters

IPC: G01N21/55

CPC classification number: C12Q1/6837 ,  G01N21/553 ,  G01N21/6428 ,  G01R3/00 ,  H01L31/02327

Abstract: An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels.

Abstract translation: 集成的等离子体感测装置是单片集成的，并且提供无标记检测（消除了使用荧光或吸收标记的需要）和在每个检测区域的条件的原位监测。 集成等离子体感测装置包括设置在单片集成的图像传感器上的等离子体激元背板。 在等离子体激元感测装置中提供一个或多个等离子体激发散射区域和横向偏离等离子体激发散射区域的一个或多个等离子体通过区域。 引导等离激元模式通过等离子体激元背板将功率传递介导到一个或多个底层图像传感器像素。

公开(公告)号：US10481089B2

公开(公告)日：2019-11-19

申请号：US14775266

申请日：2013-12-03

Applicant: Integrated Plasmonics Corporation

Inventor： Robert Joseph Walters

IPC: G01N21/552

Abstract: A detection system includes a planar plasmonic element for analyzing an analyte, the plasmonic element having dielectric and metallic regions, the plasmonic element emitting light that carries detected information; and a planar two-dimensional image sensor positioned in non-parallel angled relationship with respect to a plane of the plasmonic element to enhance a spatial image resolution for the light that carries detected information with respect to at least a portion of the light.

公开(公告)号：US20150377780A1

公开(公告)日：2015-12-31

申请号：US14766551

申请日：2013-12-03

Applicant: INTEGRATED PLASMONICS CORPORATION

Inventor： Robert Joseph Walters ,  Francisco Richard LePort

IPC: G01N21/552 ,  G01N21/47

CPC classification number: G01N21/554 ,  G01N21/4788 ,  G01N21/553 ,  G01N2201/062

Abstract: A device for detecting an analyte includes a light source emitting substantially monochromatic light; a two-dimensional diffraction element that interacts with the light from the light source, the diffraction element having one or more features that can generate plasmon waves upon receipt of the light from the light source, at least some of the features being configured to interact with the analyte; and a two-dimensional image sensor facing the diffraction element to receive diffracted light from the diffraction element so as to detect a diffraction pattern projected thereto and to measure a two-dimensional spatial change in the diffraction pattern that occurs as a result of the analyte interacting with the feature of the diffraction element.

Abstract translation: 用于检测分析物的装置包括发射基本单色光的光源; 与来自光源的光相互作用的二维衍射元件，所述衍射元件具有一个或多个特征，其在从光源接收到光时可产生等离子体波，所述特征中的至少一些被配置为与 分析物; 以及面向衍射元件的二维图像传感器，以从衍射元件接收衍射光，以便检测投影到其上的衍射图案，并测量作为分析物相互作用的结果发生的衍射图案的二维空间变化 具有衍射元件的特征。

公开(公告)号：US20150308893A1

公开(公告)日：2015-10-29

申请号：US14648843

申请日：2013-12-03

Applicant: INTEGRATED PLASMONICS CORPORATION

Inventor： Robert Joseph Walters

IPC: G01J3/02 ,  G01N21/64

CPC classification number: G01J3/0229 ,  G01J3/0208 ,  G01J3/42 ,  G01N21/64 ,  G02B5/008

Abstract: A spectroscopic measurement system, which may utilize multiple plasmonic filters associated with a cuvette to monitor different wavelengths of light. The spectroscopic measurement system may measure absorbance and or fluorescence, and may have built-in low cost CMOS image sensor(s). Reagents and samples may be introduced to the cuvette from a fluidics manifold. Multiple sets of combined cuvettes, image sensors and plasmonic filters may utilize a single fluidics manifold for reagent and sample distribution.

Abstract translation: 一种光谱测量系统，其可以利用与比色皿相关联的多个等离子体激元滤波器来监测不同波长的光。 光谱测量系统可以测量吸光度和/或荧光，并且可以具有内置的低成本CMOS图像传感器。 试剂和样品可以从流体歧管引入试管。 多套组合的比色皿，图像传感器和等离子体激元过滤器可以利用单个流体歧管进行试剂和样品分布。

公开(公告)号：US20130100454A1

公开(公告)日：2013-04-25

申请号：US13717201

申请日：2012-12-17

Applicant: INTEGRATED PLASMONICS CORPORATION

Inventor： Robert Joseph Walters

IPC: G01N21/55

CPC classification number: C12Q1/6837 ,  G01N21/553 ,  G01N21/6428 ,  G01R3/00 ,  H01L31/02327

Abstract: An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels.

Abstract translation: 集成的等离子体感测装置是单片集成的，并且提供无标记检测（消除了使用荧光或吸收标记的需要）和在每个检测区域的条件的原位监测。 集成等离子体感测装置包括设置在单片集成的图像传感器上的等离子体激元背板。 在等离子体激元感测装置中提供一个或多个等离子体激发散射区域和横向偏离等离子体激发散射区域的一个或多个等离子体通过区域。 引导等离激元模式通过等离子体激元背板将功率传递介导到一个或多个底层图像传感器像素。