公开(公告)号：US20190224677A1

公开(公告)日：2019-07-25

申请号：US15875905

申请日：2018-01-19

Applicant: International Business Machines Corporation

Inventor： Joshua T. Smith ,  Stacey M. Gifford ,  Sung-Cheol Kim ,  Benjamin H. Wunsch

IPC: B01L3/00 ,  G01N1/40

Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid, an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.

公开(公告)号：US20180272048A1

公开(公告)日：2018-09-27

申请号：US15927443

申请日：2018-03-21

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Stacey M. Gifford ,  Huan Hu ,  Emily R. Kinser ,  Roy R. Yu ,  Sufi Zafar

IPC: A61L31/16 ,  B82B3/00 ,  A61L31/06 ,  A61L31/10 ,  A61L31/08

Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.

公开(公告)号：US20180272047A1

公开(公告)日：2018-09-27

申请号：US15927428

申请日：2018-03-21

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Stacey M. Gifford ,  Huan Hu ,  Emily R. Kinser ,  Roy R. Yu ,  Sufi Zafar

IPC: A61L31/16 ,  B82B3/00 ,  A61L31/06 ,  A61L31/10 ,  A61L31/08

CPC classification number: A61L31/16 ,  A61L27/06 ,  A61L27/306 ,  A61L27/34 ,  A61L27/50 ,  A61L31/06 ,  A61L31/088 ,  A61L31/10 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  B81B2203/0361 ,  B81B2207/056 ,  B81C1/00206 ,  B82B3/0019 ,  B82B3/0033

Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.

公开(公告)号：US20180080857A1

公开(公告)日：2018-03-22

申请号：US15270478

申请日：2016-09-20

Applicant: International Business Machines Corporation

Inventor： Stacey M. Gifford ,  Gustavo A. Stolovitzky ,  Benjamin H. Wunsch

IPC: G01N1/34 ,  G01N33/543

CPC classification number: G01N1/34 ,  B01D15/34 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2400/0415 ,  G01N1/40 ,  G01N30/0005 ,  G01N33/537

Abstract: Techniques for phosphoprotein detection, quantification, and purification using a chip-based pillar array are provided. In one aspect, a method for purifying a protein sample includes: introducing a mixture including the protein sample and an antibody to a nanoDLD array having a plurality of pillars separated by a gap g, wherein the antibody and proteins in the protein sample form antibody-protein complexes having a size that is greater than a size threshold of the nanoDLD array created by the gap g which permits size-based separation of the antibody-protein complexes as the mixture flows through the nanoDLD array; and collecting a purified protein sample containing the antibody-protein complexes from the nanoDLD array. A lab-on-a-chip (LOC) device including the nanoDLD array is also provided.

公开(公告)号：US11754476B2

公开(公告)日：2023-09-12

申请号：US18061635

申请日：2022-12-05

Applicant: International Business Machines Corporation

Inventor： Benjamin H. Wunsch ,  Joshua T. Smith ,  Sung-Cheol Kim ,  Stacey M. Gifford

IPC: G01N1/40 ,  B01D29/44 ,  B01L3/00

CPC classification number: G01N1/4077 ,  B01D29/44 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/0858 ,  B01L2400/086

Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx/Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.

公开(公告)号：US11172680B2

公开(公告)日：2021-11-16

申请号：US16298101

申请日：2019-03-11

Applicant: International Business Machines Corporation

Inventor： Stacey M. Gifford ,  Huan Hu ,  Pablo M. Rojas ,  Gustavo A. Stolovitzky

IPC: A01N25/34 ,  B81C1/00 ,  C09K13/08 ,  A01N59/16 ,  B81C99/00 ,  C30B33/10 ,  H01L21/3213 ,  H01L21/306 ,  C30B33/08 ,  B82Y40/00 ,  B82Y30/00 ,  B82Y5/00

Abstract: The method comprises contacting a silicon substrate with a silver salt and an acid for a time effective to produce spikes having a first end disposed on the silicon substrate and a second end extending away from the silicon substrate. The spikes have a second end diameter of about 10 nm to about 200 nm, a height of about 100 nm to 10 micrometers, and a density of about 10 to 100 per square microns. The nanostructures provide antimicrobial properties and can be transferred to the surface of various materials such as polymers.

公开(公告)号：US20210114028A1

公开(公告)日：2021-04-22

申请号：US17132849

申请日：2020-12-23

Applicant: International Business Machines Corporation

Inventor： Joshua T. Smith ,  Stacey M. Gifford ,  Sung-Cheol Kim ,  Benjamin H. Wunsch

IPC: B01L3/00 ,  G01N1/40

Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid, an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.

公开(公告)号：US20190331561A1

公开(公告)日：2019-10-31

申请号：US16506826

申请日：2019-07-09

Applicant: International Business Machines Corporation

Inventor： Stacey M. Gifford ,  Gustavo A. Stolovitzky ,  Benjamin H. Wunsch

IPC: G01N1/34 ,  G01N33/537 ,  G01N30/00 ,  B01L3/00 ,  B01D15/34 ,  G01N1/40

Abstract: Techniques for phosphoprotein detection, quantification, and purification using a chip-based pillar array are provided. In one aspect, a method for purifying a protein sample includes: introducing a mixture including the protein sample and an antibody to a nanoDLD array having a plurality of pillars separated by a gap g, wherein the antibody and proteins in the protein sample form antibody-protein complexes having a size that is greater than a size threshold of the nanoDLD array created by the gap g which permits size-based separation of the antibody-protein complexes as the mixture flows through the nanoDLD array; and collecting a purified protein sample containing the antibody-protein complexes from the nanoDLD array. A lab-on-a-chip (LOC) device including the nanoDLD array is also provided.

公开(公告)号：US10292384B2

公开(公告)日：2019-05-21

申请号：US14973984

申请日：2015-12-18

Applicant: International Business Machines Corporation

Inventor： Stacey M. Gifford ,  Huan Hu ,  Pablo M. Rojas ,  Gustavo A. Stolovitzky

IPC: B81C1/00 ,  B82Y5/00 ,  B81C99/00 ,  B82Y30/00 ,  B82Y40/00 ,  C09K13/08 ,  C30B33/10 ,  A01N25/10 ,  A01N25/34 ,  A01N59/16 ,  C30B33/08 ,  H01L21/306 ,  H01L21/3213

Abstract: The method comprises contacting a silicon substrate with a silver salt and an acid for a time effective to produce spikes having a first end disposed on the silicon substrate and a second end extending away from the silicon substrate. The spikes have a second end diameter of about 10 nm to about 200 nm, a height of about 100 nm to 10 micrometers, and a density of about 10 to 100 per square microns. The nanostructures provide antimicrobial properties and can be transferred to the surface of various materials such as polymers.

公开(公告)号：US10946380B2

公开(公告)日：2021-03-16

申请号：US15875905

申请日：2018-01-19

Applicant: International Business Machines Corporation

Inventor： Joshua T. Smith ,  Stacey M. Gifford ,  Sung-Cheol Kim ,  Benjamin H. Wunsch

IPC: G01N1/34 ,  G01N15/06 ,  G01N33/00 ,  B01L3/00 ,  G01N1/40

Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid, an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.