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    Pulse generator for cranial nerve stimulation
    3.
    发明授权
    Pulse generator for cranial nerve stimulation 有权
    用于颅神经刺激的脉冲发生器

    公开(公告)号：US09364674B2

    公开(公告)日：2016-06-14

    申请号：US13990348

    申请日：2011-11-30

    申请人： Ian A. Cook ,  Christopher M. DeGiorgio ,  Leon Ekchian ,  Patrick Miller ,  Colin Kealey

    发明人： Ian A. Cook ,  Christopher M. DeGiorgio ,  Leon Ekchian ,  Patrick Miller ,  Colin Kealey

    IPC分类号： A61N1/37 ,  A61N1/36 ,  A61N1/04 ,  A61N1/372 ,  A61N1/375

    CPC分类号： A61N1/36025 ,  A61N1/0456 ,  A61N1/36128 ,  A61N1/37235 ,  A61N1/37247 ,  A61N1/3758

    摘要： A system for trigeminal nerve stimulation includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.

    摘要翻译： 一种用于三叉神经刺激的系统包括存储介质，与存储介质通信的脉冲发生器，耦合到脉冲发生器的电源以及通信地耦合到脉冲发生器的至少一个电极。 所述脉冲发生器包括执行来自所述存储介质的指令的微控制器，并且所述微控制器被配置为执行以下操作中的至少一个：产生具有确定特性的电脉冲，记录使用日志和异常事件，限制对特定个体的使用 与电极接口，向指定的个体提供指示操作条件和故障条件的信号，并向指定的个体提供指示治疗期结束的信号。

    PULSE GENERATOR FOR CRANIAL NERVE STIMULATION
    4.
    发明申请
    PULSE GENERATOR FOR CRANIAL NERVE STIMULATION 有权
    脉冲神经刺激脉冲发生器

    公开(公告)号：US20140081353A1

    公开(公告)日：2014-03-20

    申请号：US13990348

    申请日：2011-11-30

    申请人： Ian A. Cook ,  Christopher M. DeGiorgio ,  Leon Ekchian ,  Patrick Miller ,  Colin Kealey

    发明人： Ian A. Cook ,  Christopher M. DeGiorgio ,  Leon Ekchian ,  Patrick Miller ,  Colin Kealey

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36025 ,  A61N1/0456 ,  A61N1/36128 ,  A61N1/37235 ,  A61N1/37247 ,  A61N1/3758

    摘要： Disclosed herein is a system for trigeminal nerve stimulation. In one embodiment, the system includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.

    摘要翻译： 本文公开了一种用于三叉神经刺激的系统。 在一个实施例中，系统包括存储介质，与存储介质通信的脉冲发生器，耦合到脉冲发生器的电源以及通信地耦合到脉冲发生器的至少一个电极。 脉冲发生器包括执行来自存储介质的指令的微控制器，并且微控制器被配置为执行以下操作中的至少一个：产生具有确定特性的电脉冲，记录使用日志和异常事件，限制对特定个体的使用 与电极接口，向指定的个体提供指示操作条件和故障条件的信号，并向指定的个体提供指示治疗期结束的信号。

    Systems, devices and methods for the treatment of neurological disorders and conditions
    5.
    发明授权
    Systems, devices and methods for the treatment of neurological disorders and conditions 有权
    用于治疗神经障碍和病症的系统，装置和方法

    公开(公告)号：US08688220B2

    公开(公告)日：2014-04-01

    申请号：US12898675

    申请日：2010-10-05

    申请人： Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin

    发明人： Christopher DeGiorgio ,  Ian A. Cook ,  Alejandro Covalin

    IPC分类号： A61N1/04

    CPC分类号： A61N1/36082 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/36014 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36096 ,  A61N1/36157 ,  A61N1/3616 ,  A61N1/36171 ,  A61N1/36175

    摘要： The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

    摘要翻译： 本公开涉及用于治疗和/或促进从各种神经障碍和病症恢复的方法，装置和系统，包括癫痫和其他癫痫发作障碍以及运动和其它相关疾病; 用于促进急性或慢性脑损伤（例如中风，缺氧/缺血，头部创伤，蛛网膜下腔出血和其他形式的脑损伤）的恢复，用于唤醒和/或促进各种昏迷水平的患者的恢复，改变的精神状态或 营养状态）; 或通过外部（皮肤）刺激面部和额头中三叉神经的感觉分支来促进慢性日常头痛和偏头痛及相关疾病的恢复。 更具体地，公开了被配置用于刺激眶上，眶上，眶下，z骨，z骨，z骨，z骨，鼻和神经性神经的装置和电极组件。

    Method and apparatus for determining brain activity including the nature of brain lesions by electroencephalography
    9.
    发明授权
    Method and apparatus for determining brain activity including the nature of brain lesions by electroencephalography 失效
    通过脑电图测定大脑活动的方法和装置，包括脑损伤的性质

    公开(公告)号：US5309923A

    公开(公告)日：1994-05-10

    申请号：US929192

    申请日：1992-08-12

    申请人： Andrew F. Leuchter ,  Ian A. Cook

    发明人： Andrew F. Leuchter ,  Ian A. Cook

    IPC分类号： A61B5/0476 ,  A61B5/048 ,  G06F17/00

    CPC分类号： A61B5/048 ,  A61B5/4088

    摘要： Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical output in the brain region. The representative value is compared to a selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases. Mapping is used to determine activation during tasks such as motor and memory tasks, cognitive processing or other conditions, and also to assess the level of perfusion of the brain.

    摘要翻译： 通过定量脑电图确定脑损伤是通过获得脑区域的主频域中的绝对功率数据来实现的。 确定与次频域功率相关的主频域的功率数据。 两组数据相关，以获得代表脑区域电输出的值。 将代表值与选定的基本值进行比较，并将量化出发在地形图上映射。 该图用于识别和评估与包括痴呆和脱髓鞘疾病在内的疾病和折磨相关的病变。 映射用于确定诸如运动和记忆任务，认知处理或其他状况的任务期间的激活，以及评估大脑灌注水平。

    Diagnosing brain conditions by quantitative electroencephalography
    10.
    发明授权
    Diagnosing brain conditions by quantitative electroencephalography 失效
    通过定量电化学诊断脑条件

    公开(公告)号：US5230346A

    公开(公告)日：1993-07-27

    申请号：US830676

    申请日：1992-02-04

    申请人： Andrew F. Leuchter ,  Ian A. Cook

    发明人： Andrew F. Leuchter ,  Ian A. Cook

    IPC分类号： G06F17/00 ,  G06F19/00

    CPC分类号： A61B5/048 ,  A61B5/4088 ,  A61B5/4064

    摘要： Determining the brain condition of a human between normal and abnormal as determined by dementia, and selectively between dementia of the Alzheimer's-type and multi-infarct dementia is effected. Measures of electrical output, spectral ratio and coherence value of the brain are determined. Selected scores are applied to the electrical output, spectral ratio and coherence values. A relationship between the scores and addi-tionally the scored value of a coherence ratio are effected to obtain a diagnostic evaluation.

    摘要翻译： 确定由痴呆确定的正常和异常之间的人的脑部状况，并且选择性地在阿尔茨海默氏型和多梗死性痴呆的痴呆之间进行。 确定大脑电输出，光谱比和相干值的测量。 所选分数应用于电输出，频谱比和相干值。 分数之间的关系，另外还有一个相干比的得分值进行诊断评估。