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    Luminescent labelling material and procedures
    5.
    发明授权
    Luminescent labelling material and procedures 失效
    发光标签材料和程序

    公开(公告)号：US06414152B1

    公开(公告)日：2002-07-02

    申请号：US08328563

    申请日：1994-10-24

    申请人： Anthony Keith Campbell ,  James Stuart Woodhead ,  Ian Weeks

    发明人： Anthony Keith Campbell ,  James Stuart Woodhead ,  Ian Weeks

    IPC分类号： C07D21904

    CPC分类号： C07D401/12 ,  G01N33/533 ,  G03G15/0898 ,  G03G15/09

    摘要： A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitation of an antigen of interest, by initiation of the luminescent reaction and subsequent measurement of the photonic emission of the immune complex formed during the immunological reaction.

    摘要翻译： 在免疫测定中用作化学发光标记的化合物包括与N-琥珀酰亚胺基部分连接的芳基吖啶酯。 该化合物方便地与单克隆抗体或其它蛋白质连接，并用于双位点免疫测定中，用于定量感兴趣的抗原，通过引发发光反应和随后测量在期间形成的免疫复合物的光子发射 免疫反应。

    Shutter handle latch
    6.
    发明授权
    Shutter handle latch 失效
    快门把手锁

    公开(公告)号：US6094865A

    公开(公告)日：2000-08-01

    申请号：US201665

    申请日：1998-12-01

    申请人： Ian Weeks

    发明人： Ian Weeks

    IPC分类号： E05B65/00 ,  E05B65/08 ,  E05C3/14 ,  E06B9/17 ,  E06B9/80 ,  E06B7/086 ,  E06B9/56

    CPC分类号： E06B9/80 ,  E05C3/14 ,  E06B9/17046 ,  E05B65/0021 ,  E05B65/0835 ,  Y10S292/36

    摘要： A shutter, as used on fire engines, consists of a number of laths (13), which are hingedly connected together and can be drawn across an opening by handle and can be latched in the closed condition by a latch. The handle, which extends across the shutter, being formed by the mounting bracket (12), which is mounted on a lath (13), and the latch member (11) which is hingedly connected to the mounting bracket (12), thereby reducing the number of parts required and the need for separate opening and closing handles. The latch member (11) co-operates with a keeper (18) which is mounted on the structure (10) which surrounds the opening thereby latching the shutter in position.

    摘要翻译： 在消防车上使用的快门由许多板条（13）组成，它们铰接连接在一起，并且可以通过手柄拉过开口，并且可以通过闩锁在闭合状态下锁定。 延伸穿过闸门的手柄由安装在板条（13）上的安装支架（12）和铰链地连接到安装支架（12）上的闩锁构件（11）形成，从而减少 需要的零件数量和需要独立的开关手柄。 闩锁构件（11）与安装在围绕开口的结构（10）上的保持器（18）配合，从而将闸板锁定就位。

    Immunological procedure for detecting or quantifying substances
    8.
    发明授权
    Immunological procedure for detecting or quantifying substances 失效
    检测或定量物质的免疫程序

    公开(公告)号：US4761382A

    公开(公告)日：1988-08-02

    申请号：US13215

    申请日：1987-02-05

    申请人： James S. Woodhead ,  Ian Weeks

    发明人： James S. Woodhead ,  Ian Weeks

    IPC分类号： G01N33/542 ,  G01N33/536

    CPC分类号： G01N33/542 ,  Y10S436/80 ,  Y10S436/805

    摘要： This invention relates to a method of detecting, analyzing, quantifying, or locating a substance of biological interest by an immunoassay in which a first component of an immune reaction in the form of an antigen, hapten, or antibody, is linked with one or more components of a chemiluminescent reaction, and the other component of the immune reaction, the analyte, is complexed therewith to cause entropic and/or ethalpic changes in a subsequent light emitting action as compared with the reaction of uncomplexed labelled component, the reaction being observed and compared to provide information on the immune complex formation. Preferably the intensity of light emission of the rate of photonic emission or the rate of change of intensity of emission are observed compared with the equivalent properties of the uncomplexed component.

    摘要翻译： 本发明涉及通过免疫测定来检测，分析，定量或定位生物学上的物质的方法，其中抗原，半抗原或抗体形式的免疫反应的第一组分与一种或多种 化学发光反应的组分和免疫反应的另一个成分（分析物）与其结合，导致随后的发光作用中的熵和/或乙醛变化，与未络合的标记组分的反应相比，观察到的反应和 比较提供免疫复合物形成的信息。 优选地，与未复合组分的等效特性相比，观察到光子发射速率的发光强度或发射强度变化率。

    Chemiluminescent compounds
    9.
    发明申请
    Chemiluminescent compounds 审中-公开

    公开(公告)号：US20070166759A1

    公开(公告)日：2007-07-19

    申请号：US10570175

    申请日：2004-08-26

    申请人： Ian Weeks ,  Andrew Rutter ,  Zhaoqiang Li ,  Keith Smith

    发明人： Ian Weeks ,  Andrew Rutter ,  Zhaoqiang Li ,  Keith Smith

    IPC分类号： G01N33/53 ,  C07D219/02

    CPC分类号： C07D401/12 ,  C04B35/632 ,  C09B15/00 ,  C09K11/07 ,  C09K2211/1011 ,  C09K2211/1029 ,  G01N33/582

    摘要： The invention relates to chemiluminescent compounds of general formula: (I) wherein: either: R1 is a reactive group capable of reacting with an amine or thiol moiety; L1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aryl, fused aryl, C1-C4 alkoxy, C1-C4acyl, halide, hydroxy or nitro; or, alternatively: the combination R1-L1- comprises a C1-C4 alkyl group optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2 comprises a group R4-L1-, where R4 is a reactive group capable of reacting with an amine or thiol moiety; and L1 is as defined above; L2 is —C(═O)O—, —C(═O)—S— or —C(═O)N(SO2R5)—, wherein, in each case, the —C(═O) is linked to the ring carbon atom, and R5 is C1-C8 alkyl, aryl, C1-C8 alkoxy or C1-C8 acyl; R3 a substituted C1-C8 alkyl, C2-C8 alkenyl, C1-C8 alkynyl or aryl group wherein at least one of the said substituents is electron-withdrawing such that the pKa of the conjugate acid of the leaving group formed from R3 and the —O, —S or —N(SO2R5) of the L2 group is ≦ about 9.5; and X− is an anion formed as the result of the synthesis and processing of the molecule; wherein the compound may contain one or more additional R2 moieties on either or both outer rings, provided that only one of said R2 moieties may comprise an R4-L1-group.

    Monitoring oligonucleotide binding processes using chemiluminescence quenching
    10.
    发明授权
    Monitoring oligonucleotide binding processes using chemiluminescence quenching 失效
    使用化学发光猝灭监测寡核苷酸结合过程

    公开(公告)号：US07169554B2

    公开(公告)日：2007-01-30

    申请号：US10149146

    申请日：2000-12-11

    申请人： Andrew James Rutter ,  Ian Weeks ,  Zhaoqiang Li ,  Keith Smith

    发明人： Andrew James Rutter ,  Ian Weeks ,  Zhaoqiang Li ,  Keith Smith

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6818 ,  C12Q2565/101

    摘要： Oligonucleotide building processes are monitored by means of an oligonucleotide probe which in one embodiment is labelled at one end with a chemiluminescent label and at the other end with a quencher molecule. The conformation of the oligonucleotide probe changes according to whether the probe hybridises with a substantially complementary nucleic acid sequence. In the non-hybridised state the chemiluminescent label is sufficiently close proximity to the quencher that the chemiluminescent emission is substantially attenuated, but in the hybridised state the separation is such that there is little or no attenuation. Particular probes and emitter/quencher pairs are disclosed.

    摘要翻译： 通过寡核苷酸探针监测寡核苷酸构建过程，寡核苷酸探针在一个实施方案中在一端用化学发光标记物标记，另一端用猝灭剂分子标记。 寡核苷酸探针的构象根据探针是否与基本互补的核酸序列杂交而变化。 在非杂交状态下，化学发光标记与猝灭剂充分接近，化学发光发射基本上被衰减，但在杂交状态下，分离使得几乎没有或没有衰减。 公开了特定的探针和发射/猝灭剂对。