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13 条记录 (耗时 0.014 秒)

    Passivating fissures in substrates
    1.
    发明授权
    Passivating fissures in substrates 有权

    公开(公告)号：US10793963B2

    公开(公告)日：2020-10-06

    申请号：US16616867

    申请日：2018-12-11

    申请人： ILLUMINA, INC.

    发明人： Hayden Black

    IPC分类号： C25D9/02 ,  B01L3/00 ,  G01N27/414

    摘要： Provided in one example is a sensor having at least one fissure, the fissure being at least partially filled by at least one polymer formation extending vertically within a passivation layer. The polymer formation protects the underlying metal containing layer from corrosive solutions. Provided in another example is a method of forming the polymer formation in a fissure of a sensor.

    DEVICES INCLUDING PARTICLES COUPLED TO ELECTRODES, AND METHODS OF MAKING AND USING THE SAME
    3.
    发明公开
    DEVICES INCLUDING PARTICLES COUPLED TO ELECTRODES, AND METHODS OF MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20230175055A1

    公开(公告)日：2023-06-08

    申请号：US17921941

    申请日：2021-05-06

    申请人： Illumina, Inc.

    发明人： Rico Otto ,  Hayden Black ,  Jeffrey Mandell

    IPC分类号： C12Q1/6869

    CPC分类号： C12Q1/6869

    摘要： In some examples, a device includes first and second electrodes separated from one another by a space; a particle coupled to the first electrode via a first plurality of bonds, and coupled to the second electrode via a second plurality of bonds; and a polymerase coupled to the particle. In some examples, a composition includes first and second electrodes separated from one another by a space; a fluid including a first electrically conductive label having a length at least as long as a length of the space; and detection circuitry to generate a first signal responsive to transient formation, using the first electrically conductive label, of a first electrically conductive bridge between the first and second electrodes.

    ON-FLOW CELL THREE DIMENSIONAL POLYMER STRUCTURES
    4.
    发明申请
    ON-FLOW CELL THREE DIMENSIONAL POLYMER STRUCTURES 有权

    公开(公告)号：US20220143603A1

    公开(公告)日：2022-05-12

    申请号：US17435229

    申请日：2020-11-25

    申请人： ILLUMINA, INC.

    发明人： Tarun Kumar Khurana ,  Elisabet ROSAS-CANYELLES ,  Yir-shyuan WU ,  Hayden Black ,  Mathieu LESSARD-VIGER ,  Max Zimmerly ,  Sean Ramirez

    IPC分类号： B01L3/00 ,  C08F2/48 ,  G03F7/00 ,  B01L7/00 ,  C40B30/04 ,  G03F7/028 ,  C08F220/56

    摘要： A method for making on-flow cell three-dimensional polymer structures includes loading a polymer precursor solution onto a flow cell. The polymer precursor solution includes a monomer, a crosslinker, and a photoinitiator. The flow cell includes at least one channel for receiving the polymer precursor solution. The at least one channel has an upper interior surface and a lower interior surface. The method further includes illuminating the polymer precursor solution through a patterned photomask using a light at a wavelength sufficient to activate the photoinitiator. Activation of the photoinitiator polymerizes at least some of the polymer precursor solution underneath apertures in the patterned photomask and forms three-dimensional polymer structures that extend from the upper interior surface to the lower interior surface of the at least one channel.

    COMPOSITIONS AND METHODS FOR CAPTURING AND AMPLIFYING TARGET POLYNUCLEOTIDES USING MODIFIED CAPTURE PRIMERS
    6.
    发明公开
    COMPOSITIONS AND METHODS FOR CAPTURING AND AMPLIFYING TARGET POLYNUCLEOTIDES USING MODIFIED CAPTURE PRIMERS 审中-公开

    公开(公告)号：US20240011080A1

    公开(公告)日：2024-01-11

    申请号：US18000663

    申请日：2021-12-20

    申请人： Illumina, Inc.

    发明人： Hayden Black ,  Esteban Armijo ,  Mathieu Lessard-Viger

    IPC分类号： C12Q1/6837

    CPC分类号： C12Q1/6837

    摘要： A composition for capturing target polynucleotides at a surface of a substrate is provided. The composition may include a plurality of capture primers coupled to the surface of the substrate and including modified nucleic acids; and a plurality of orthogonal capture primers coupled to the surface of the substrate and including modified nucleic acids. The modified nucleic acids of the capture primers may include locked nucleic acid (LNA), peptide nucleic acid (PNA), or super T. The modified nucleic acids of the orthogonal capture primers may include locked nucleic acid (LNA), peptide nucleic acid (PNA), or super T.

    Flow cells and sequencing kits
    7.
    发明授权
    Flow cells and sequencing kits 有权

    公开(公告)号：US11841310B2

    公开(公告)日：2023-12-12

    申请号：US16701863

    申请日：2019-12-03

    申请人： ILLUMINA, INC.

    发明人： Hayden Black ,  Brian D. Mather

    IPC分类号： G01N15/14 ,  C12Q1/6869 ,  B01L3/00

    CPC分类号： G01N15/1404 ,  C12Q1/6869 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/0893

    摘要： In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode. In this example, the patterned material includes depressions separated by interstitial regions, and a functionalized surface of the electrode is exposed at each of the depressions. In this example, the flow cell further includes a primer grafted to the functionalized surface in each of the depressions. In another example, a flow cell includes a substrate and a patterned electrode positioned on the substrate. In this other example, the patterned electrode includes depressions separated by interstitial regions, and a functionalized surface of the substrate exposed at each of the depressions. In this other example, a primer is grafted to the functionalized surface in each of the depressions.

    Passivating Fissures in Substrates
    8.
    发明申请
    Passivating Fissures in Substrates 审中-公开

    公开(公告)号：US20200102665A1

    公开(公告)日：2020-04-02

    申请号：US16616867

    申请日：2018-12-11

    申请人： ILLUMINA, INC.

    发明人： Hayden Black

    IPC分类号： C25D9/02 ,  G01N27/414 ,  B01L3/00

    摘要： Provided in one example is a sensor having at least one fissure, the fissure being at least partially filled by at least one polymer formation extending vertically within a passivation layer. The polymer formation protects the underlying metal containing layer from corrosive solutions. Provided in another example is a method of forming the polymer formation in a fissure of a sensor.

    FLOW CELLS AND SEQUENCING KITS
    9.
    发明公开
    FLOW CELLS AND SEQUENCING KITS 审中-公开

    公开(公告)号：US20240183770A1

    公开(公告)日：2024-06-06

    申请号：US18534113

    申请日：2023-12-08

    申请人： ILLUMINA, INC.

    发明人： Hayden Black ,  Brian D. Mather

    IPC分类号： G01N15/1404 ,  B01L3/00 ,  C12Q1/6869

    CPC分类号： G01N15/1404 ,  C12Q1/6869 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/0893

    摘要： In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode. In this example, the patterned material includes depressions separated by interstitial regions, and a functionalized surface of the electrode is exposed at each of the depressions. In this example, the flow cell further includes a primer grafted to the functionalized surface in each of the depressions. In another example, a flow cell includes a substrate and a patterned electrode positioned on the substrate. In this other example, the patterned electrode includes depressions separated by interstitial regions, and a functionalized surface of the substrate exposed at each of the depressions. In this other example, a primer is grafted to the functionalized surface in each of the depressions.

    COMPOSITIONS AND METHODS FOR SEQUENCING USING POLYMERS WITH METAL-COATED REGIONS AND EXPOSED REGIONS
    10.
    发明公开
    COMPOSITIONS AND METHODS FOR SEQUENCING USING POLYMERS WITH METAL-COATED REGIONS AND EXPOSED REGIONS 审中-公开

    公开(公告)号：US20240158849A1

    公开(公告)日：2024-05-16

    申请号：US18552524

    申请日：2022-02-08

    申请人： Illumina, Inc.

    发明人： Rico Otto ,  Hayden Black

    IPC分类号： C12Q1/6869 ,  G01N27/327

    CPC分类号： C12Q1/6869 ,  G01N27/3275

    摘要： Provided herein are compositions and methods for sequencing using metal-coated polymers. In some examples, a bridge spans a space between first and second electrodes and includes a polymer chain having a first metal-coated region contacting the first electrode, a second metal-coated region contacting the second electrode, and an exposed region located between the first and second regions. The composition includes first and second polynucleotides; a plurality of nucleotides, each nucleotide coupled to a corresponding label; and a polymerase to add nucleotides of the plurality of nucleotides to the first polynucleotide using at least a sequence of the second polynucleotide. The composition includes detection circuitry to detect a sequence in which the polymerase adds the nucleotides to the first polynucleotide using at least changes in an electrical signal through the bridge, the changes being responsive to contact between the labels corresponding to those nucleotides and the exposed region.