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公开(公告)号:US20210172972A1
公开(公告)日:2021-06-10
申请号:US17113115
申请日:2020-12-07
Applicant: Industrial Technology Research Institute
Inventor: Chih-Wen Yang , Ruey-Shyan Hong , Tzu-Hui Wu , Ting-Hsuan Chen
Abstract: A nucleic acid extracting device includes a reagent containing unit, a mixing unit, and a flow channel unit. The reagent containing unit contains a specimen, a magnetic bead, and a reagent for extracting. The mixing unit includes a mixing chamber and a stirring assembly. The mixing chamber includes a chamber portion and a tube portion. The stirring assembly includes a main body and an extension. The main body is provided in the chamber portion. The tube portion connects the chamber portion. And the extension connects the main body and extends into the tube portion. The extension and an inner wall of the tube portion have first and second gaps therebetween respectively along first and second directions of the tube portion. The first gap is less than the second gap. The flow channel unit is connected between the reagent containing unit and the mixing unit.
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公开(公告)号:US20230201840A1
公开(公告)日:2023-06-29
申请号:US17564243
申请日:2021-12-29
Applicant: Industrial Technology Research Institute
Inventor: Chun-Chuan Lin , Hsiao-Yue Tsao , Shih-Bin Luo , Kuo-Hsing Wen , Chien-Chih Kuo , Ping-Jung Wu , Ruey-Shyan Hong , Ting-Hsuan Chen
CPC classification number: B01L7/52 , G01N21/6486 , B01L9/527 , G01N2021/6419 , G01N2021/6421 , C12Q1/686
Abstract: A convective polymerase chain reaction apparatus and an optical detecting method thereof are provided. The optical detecting method includes the following steps. A substance in a tube to be tested is heated. At least two monochromatic lights are provided and are combined using a light combining element to irradiate the tube to be tested. At least two excited lights generated by exciting the substance in the tube to be tested by the at least two monochromatic lights are sensed.
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公开(公告)号:US09505003B2
公开(公告)日:2016-11-29
申请号:US14582697
申请日:2014-12-24
Applicant: Industrial Technology Research Institute
Inventor: Chih-Hsiang Sung , Tseng-Huang Liu , Ruey-Shyan Hong , Ting-Hsuan Chen , Ping-Jung Wu , Kuo-Hsing Wen , Wan-Chi Chang
CPC classification number: B01L7/52 , B01L9/06 , B01L2200/18 , B01L2300/046 , B01L2300/0663 , B01L2300/1805 , B01L2300/1844
Abstract: A portable real-time heating and detection device includes a body, a cover and a detection unit. The body has an opening, and a base. The cover has a control unit and a fix unit. The detection unit is disposed on the base of the body and has a thermostat, an optical excitation, an optical detection, and a circuit board. The thermostat is disposed close to the opening and has at least one thermostat zone. The optical exciter is disposed between the thermostat and the base. The optical detector is disposed between the thermostat and the opening. The circuit board is electrical coupled to the control unit, the thermostat, the optical excitation, and the optical detector, respectively.
Abstract translation: 便携式实时加热和检测装置包括主体,盖和检测单元。 身体有一个开口和一个基地。 盖具有控制单元和固定单元。 检测单元设置在主体的基座上并具有恒温器,光学激励,光学检测和电路板。 恒温器靠近开口设置,并具有至少一个恒温区。 光激发器设置在恒温器和基座之间。 光学检测器设置在恒温器和开口之间。 电路板分别电耦合到控制单元,恒温器,光学激励和光学检测器。
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公开(公告)号:US11733258B2
公开(公告)日:2023-08-22
申请号:US17113115
申请日:2020-12-07
Applicant: Industrial Technology Research Institute
Inventor: Chih-Wen Yang , Ruey-Shyan Hong , Tzu-Hui Wu , Ting-Hsuan Chen
IPC: G01N35/10 , C12N15/10 , B01F27/072 , B01F27/90 , B01F27/1125 , G01N35/00
CPC classification number: G01N35/1065 , B01F27/0724 , B01F27/11251 , B01F27/90 , C12N15/1003 , C12N15/1013 , G01N2035/00534 , G01N2035/00564 , G01N2035/1053
Abstract: A nucleic acid extracting device includes a reagent containing unit, a mixing unit, and a flow channel unit. The reagent containing unit contains a specimen, a magnetic bead, and a reagent for extracting. The mixing unit includes a mixing chamber and a stirring assembly. The mixing chamber includes a chamber portion and a tube portion. The stirring assembly includes a main body and an extension. The main body is provided in the chamber portion. The tube portion connects the chamber portion. And the extension connects the main body and extends into the tube portion. The extension and an inner wall of the tube portion have first and second gaps therebetween respectively along first and second directions of the tube portion. The first gap is less than the second gap. The flow channel unit is connected between the reagent containing unit and the mixing unit.
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公开(公告)号:US11358137B2
公开(公告)日:2022-06-14
申请号:US16726940
申请日:2019-12-26
Applicant: Industrial Technology Research Institute
Inventor: Shaw-Hwa Parng , Su-Jan Lee , Ping-Jung Wu , Ruey-Shyan Hong , Yu-Yin Tsai
Abstract: A tubular structure for producing droplets and a method of using the tubular structure to produce droplets are provided. The tubular structure includes microchannel structures, and is used for droplet generation, droplet collection, nucleic acid amplification and/or in situ droplet detection, etc.
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公开(公告)号:US20200261903A1
公开(公告)日:2020-08-20
申请号:US16726940
申请日:2019-12-26
Applicant: Industrial Technology Research Institute
Inventor: Shaw-Hwa Parng , Su-Jan Lee , Ping-Jung Wu , Ruey-Shyan Hong , Yu-Yin Tsai
Abstract: A tubular structure for producing droplets and a method of using the tubular structure to produce droplets are provided. The tubular structure includes microchannel structures, and is used for droplet generation, droplet collection, nucleic acid amplification and/or in situ droplet detection, etc.
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公开(公告)号:US20180164196A1
公开(公告)日:2018-06-14
申请号:US15381116
申请日:2016-12-16
Applicant: Industrial Technology Research Institute
Inventor: Chien-An Chen , Wen-Ching Lee , Tzu-Hui Wu , Pei-Shin Jiang , Ping-Jung Wu , Ruey-Shyan Hong , Hsiao-Jou Chang , Chun-Chieh Huang , Ting-Hsuan Chen , Chih-Lung Lin
CPC classification number: G01N1/36 , B01L3/508 , B01L7/52 , B01L2200/025 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2300/0681 , B01L2300/0832 , B01L2300/0867 , B01L2400/0478 , B01L2400/0622 , B01L2400/0644 , C12M1/42 , C12N15/10 , G01N33/48
Abstract: A biological sample processing device includes a base, a purification unit, a metering unit and a first tube. The purification unit is disposed on the base and is configured to purify a sample. The metering unit is disposed on the base and has an inlet, at least one metering trough and an overflow trough. The inlet is connected to the purification unit via the first tube, and the metering trough is connected between the inlet and the overflow trough. The sample from the purification unit is configured to enter the metering unit through the inlet to be moved toward the metering trough, and to be moved toward the overflow trough after the metering trough is filled with the sample.
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