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    Process for producing coated solid dosage forms
    1.
    发明授权
    Process for producing coated solid dosage forms 有权
    生产包衣固体剂型的方法

    公开(公告)号：US06350398B1

    公开(公告)日：2002-02-26

    申请号：US09385459

    申请日：1999-08-30

    申请人： Jörg Breitenbach ,  Stephan Kothrade ,  Andreas Kleinke ,  Armin Lange ,  Werner Maier

    发明人： Jörg Breitenbach ,  Stephan Kothrade ,  Andreas Kleinke ,  Armin Lange ,  Werner Maier

    IPC分类号： A61K932

    CPC分类号： A61K9/2095 ,  A61K9/2893

    摘要： The invention relates to a process for producing coated solid dosage forms by forming a plastic mixture from at least one thermoplastic physiologically tolerated polymeric binder and at least one active ingredient and extruding the plastic mixture, wherein the extrudate is subsequently treated with at least one liquid or vaporized coating agent, and the coated extrudate is shaped to the required dosage form.

    摘要翻译： 本发明涉及通过从至少一种热塑性生理上耐受的聚合物粘合剂和至少一种活性成分形成塑料混合物并挤出塑料混合物来生产涂覆的固体剂型的方法，其中挤出物随后用至少一种液体或 蒸发的涂覆剂，并且涂布的挤出物成形为所需的剂型。

    Process for producing solid dosage forms
    2.
    发明授权
    Process for producing solid dosage forms 有权
    生产固体剂型的方法

    公开(公告)号：US06423256B1

    公开(公告)日：2002-07-23

    申请号：US09417070

    申请日：1999-10-13

    申请人： Stephan Kothrade ,  Jörg Breitenbach ,  Harald Krull ,  Thomas Kessler ,  Armin Lange ,  Werner Maier ,  Ulrich Reinhold

    发明人： Stephan Kothrade ,  Jörg Breitenbach ,  Harald Krull ,  Thomas Kessler ,  Armin Lange ,  Werner Maier ,  Ulrich Reinhold

    IPC分类号： A61K920

    CPC分类号： A61K31/192 ,  A61K9/2027 ,  A61K9/2095

    摘要： A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.

    摘要翻译： 一种制备固体剂型的方法，其中（i）至少一种药理学上可接受的聚合物粘合剂与K值大于75的塑料混合物，至少一种药物活性成分以及适当的常规药物添加剂，以及 （ii）将塑料混合物成形为所需剂型，步骤（i）在温度和剪切能量输入条件下进行，使得聚合物粘合剂的分子量的降低表示为K值的差异 ，小于15被描述。

    Gas phase fluidized bed method and ethylene homo- and copolymers obtained using said method
    4.
    发明授权
    Gas phase fluidized bed method and ethylene homo- and copolymers obtained using said method 有权
    气相流化床法和使用所述方法获得的乙烯均聚物和共聚物

    公开(公告)号：US06649709B1

    公开(公告)日：2003-11-18

    申请号：US09555594

    申请日：2000-05-31

    申请人： Peter Bauer ,  Armin Lange ,  Rainer Karer ,  Philipp Rosendorfer ,  Manfred Hecker ,  Günther Schweier ,  Wolfgang Micklitz ,  Kaspar Evertz ,  Hans-Jacob Feindt

    发明人： Peter Bauer ,  Armin Lange ,  Rainer Karer ,  Philipp Rosendorfer ,  Manfred Hecker ,  Günther Schweier ,  Wolfgang Micklitz ,  Kaspar Evertz ,  Hans-Jacob Feindt

    IPC分类号： C08F234

    CPC分类号： C08F10/02 ,  C08F4/24 ,  C08F2/34

    摘要： A continuous vapor-phase fluidized-bed process for the preparation of ethylene homopolymers and copolymers having a density of from 0.87 to 0.97 g/cm3 in which ethylene or mixtures of ethylene and C3-C8 a-monoolefins are (co)polymerized in the presence of a supported chromium catalyst in the polymerization zone of a vapor-phase fluidized-bed reactor under pressures ranging from 1 to 100 bar and at temperatures ranging from 30° to 125° C. in the vapor phase in an agitated bed of bulk material comprising particulate polymer, the resultant heat of polymerization is removed by cooling the recirculated reactor gas and the resulting (co)polymer is removed from the vapor-phase fluidized-bed reactor, wherein, for the preparation of a (co)polymer of a specific density d, the (co)polymerization is carried out at a temperature which is in a range restricted by an upper envelope defined by equation I T H = 171 + 6 ⁢ d ′ 0.84 - d ′ ( I ) and a lower envelope defined by equation II T L = 173 + 7.3 ⁢ d ′ 0.837 - d ′ , ( II ) in which the variables have the following meanings: TH is the highest reaction temperature in ° C.; TL is the lowest reaction temperature in ° C.; d′ is the numerical value of the density d of the (co)polymer to be synthesized.

    摘要翻译： 用于制备密度为0.87至0.97g / cm 3的乙烯均聚物和共聚物的连续气相流化床方法，其中乙烯或乙烯和C 3 -C 8α-单烯烃的混合物（共）聚合 在负载的铬催化剂的存在下，在气相流化床反应器的聚合区域的存在下，在压力范围为1至100巴，温度范围为30至125℃，气相在搅拌床 包含颗粒聚合物的散装材料，通过冷却再循环的反应器气体除去所得到的聚合热，并将所得（共）聚合物从气相流化床反应器中除去，其中，为制备（共）聚合物 特定密度d，（共）聚合在由等式I定义的上包络限制的范围内进行，并且由等式IIin定义的下包络，其中变量具有以下含义：T H是最高的反应温度，单位°C; TL是最低反应温度（℃）; d'是待合成的（共）聚合物的密度d的数值。

    Polyethyleneimine and polyvinylamine derivatives, aluminum-based substrate materials coated with these derivatives and the use thereof for the production of offset printing plates
    7.
    发明授权
    Polyethyleneimine and polyvinylamine derivatives, aluminum-based substrate materials coated with these derivatives and the use thereof for the production of offset printing plates 失效
    聚乙烯和聚乙烯胺衍生物，用这些衍生物涂覆的基于铝的基材料及其用于生产偏移印刷板的用途

    公开(公告)号：US5217813A

    公开(公告)日：1993-06-08

    申请号：US805179

    申请日：1991-12-11

    申请人： Joachim Roser ,  Juergen Mohr ,  Armin Lange ,  Knut Oppenlaender ,  Walter Denzinger ,  Thomas Loerzer

    发明人： Joachim Roser ,  Juergen Mohr ,  Armin Lange ,  Knut Oppenlaender ,  Walter Denzinger ,  Thomas Loerzer

    IPC分类号： C08F26/02 ,  B41F1/16 ,  B41F3/34 ,  B41F15/08 ,  B41L17/08 ,  B41N3/03 ,  C08F8/34 ,  C08F8/40 ,  C08F26/00 ,  C08G73/02 ,  C08G73/04

    CPC分类号： G03F7/11 ,  B41N3/036 ,  C08G73/0206 ,  G03F7/021 ,  G03F7/0236 ,  Y10T428/31692

    摘要： In novel polyethyleneimine and polyvinylamine derivatives, the polyethyleneimines contain the structural elements Ia and/or Ib ##STR1## and the polyvinylamines contain the structural elements II.sub.a, II.sub.b and II.sub.c ##STR2## where, for the degrees of polymerization n, m and p, n.gtoreq.1, m.gtoreq.0 and p.gtoreq.0, and X.sup.1 is CR.sup.1 R.sup.2 PO.sub.3 R.sup.3 R.sup.4 or CR.sup.1 R.sup.2 SO.sub.3 R.sup.3, X.sup.2 independently of X.sup.1 is hydrogen, CR.sup.1 R.sup.2 PO.sub.3 R.sup.3 R.sup.4 or CR.sup.1 R.sup.2 SO.sub.3 R.sup.3, Y.sup.1 and Y.sup.2 independently of one another are each one or more CHR.sup.1 PO.sub.3 R.sup.3 R.sup.4 or CHR.sup.1 SO.sub.3 R.sup.3 groups or hydrogen, Y.sup.3 and Y.sup.4 independently of one another and of Y.sup.1 and Y.sup.2 are each hydrogen, CHR.sup.1 PO.sub.3 R.sup.3 R.sup.4 or CHR.sup.1 SO.sub.3 R.sup.3, and Z.sup.1 -Z.sup.4 are identical or different inorganic and/or organic radicals, wherein R.sup.1 and R.sup.2 independently of one another are each hydrogen, C.sub.1 -C.sub.12 -alkyl or aryl and R.sup.3 and R.sup.4 independently of one another are each hydrogen, an alkali metal atom or NR.sup.5 R.sup.6 R.sup.7 R.sup.8, where R.sup.5 to R.sup.8 are identical or different radicals selected from the group consisting of hydrogen, alkyl, aryl, hydroxyalkyl and benzyl.Aluminum-based substrates coated with these polyethyleneimines and/or polyvinylamines are used for the production of offset printing plates.

    摘要翻译： 在新型聚乙烯亚胺和聚乙烯胺衍生物中，聚乙烯亚胺含有结构元素Ia和/或Ib Ib，聚乙烯胺含有结构元素IIa，IIb和IIc IIa图像IIb图像IIc 其中，对于聚合度n，m和p，n> / = 1，m> / = 0和p> / = 0，X1为CR1R2PO3R3R4或CR1R2SO3R3，独立于X1的X2为氢，CR1R2PO3R3R4或CR1R2SO3R3，Y1 和Y2彼此独立地为一个或多个CHR1PO3R3R4或CHR1SO3R3基团，或氢，Y3和Y4彼此独立且Y1和Y2各自为氢，CHR1PO3R3R4或CHR1SO3R3，Z1-Z4为相同或不同的无机和/或 有机基团，其中R 1和R 2彼此独立地为氢，C 1 -C 12 - 烷基或芳基，且R 3和R 4彼此独立地为氢，碱金属原子或NR 5 R 6 R 7 R 8，其中R 5至R 8为相同或不同的基团 选自氢，等 烷基，芳基，羟基烷基和苄基。 用这些聚乙烯亚胺和/或聚乙烯胺涂覆的铝基基材用于生产胶版印刷版。

    Vapor-phase fluidized-bed process and ethylene homopolymers and copolymers produced thereby
    8.
    发明授权
    Vapor-phase fluidized-bed process and ethylene homopolymers and copolymers produced thereby 失效
    气相流化床方法和由此制备的乙烯均聚物和共聚物

    公开(公告)号：US06849699B2

    公开(公告)日：2005-02-01

    申请号：US10658916

    申请日：2003-09-11

    申请人： Peter Bauer ,  Armin Lange ,  Rainer Karer ,  Philipp Rosendorfer ,  Manfred Hecker ,  Günther Schweier ,  Wolfgang Micklitz ,  Kaspar Evertz ,  Hans-Jacob Feindt

    发明人： Peter Bauer ,  Armin Lange ,  Rainer Karer ,  Philipp Rosendorfer ,  Manfred Hecker ,  Günther Schweier ,  Wolfgang Micklitz ,  Kaspar Evertz ,  Hans-Jacob Feindt

    IPC分类号： C08J5/18 ,  C08F2/34 ,  C08F4/02 ,  C08F4/24 ,  C08F4/69 ,  C08F10/02 ,  C08F210/02

    CPC分类号： C08F10/02 ,  C08F4/24 ,  C08F2/34

    摘要： A continuous vapor-phase fluidized-bed process for the preparation of ethylene homopolymers and copolymers having a density of from 0.87 to 0.97 g/cm3 in which ethylene or mixtures of ethylene and C3-C8 a-monoolefins are (co)polymerized in the presence of a supported chromium catalyst in the polymerization zone of a vapor-phase fluidized-bed reactor under pressures ranging from 1 to 100 bar and at temperatures ranging from 30° to 125° C. in the vapor phase in an agitated bed of bulk material comprising particulate polymer, the resultant heat of polymerization is removed by cooling the recirculated reactor gas and the resulting (co)polymer is removed from the vapor-phase fluidized-bed reactor, wherein, for the preparation of a (co)polymer of a specific density d, the (co)polymerization is carried out at a temperature which is in a range restricted by an upper envelope defined by equation I T H = 171 + 6 ⁢   ⁢ d ′ 0.84 - d ′ ( I ) and a lower envelope defined by equation II T L = 173 + 7.3 ⁢   ⁢ d ′ 0.837 - d ′ , ( II ) in which the variables have the following meanings: TH is the highest reaction temperature in ° C.; TL is the lowest reaction temperature in ° C.; d′ is the numerical value of the density d of the (co)polymer to be synthesized.

    摘要翻译： 用于制备密度为0.87至0.97g / cm 3的乙烯均聚物和共聚物的连续气相流化床方法，其中乙烯或乙烯和C 3 -C 8α-单烯烃的混合物（共）聚合 在负载的铬催化剂的存在下，在气相流化床反应器的聚合区域的存在下，在压力范围为1至100巴，温度范围为30至125℃，气相在搅拌床 包含颗粒聚合物的散装材料，通过冷却再循环的反应器气体除去所得到的聚合热，并将所得（共）聚合物从气相流化床反应器中除去，其中，为制备（共）聚合物 特定密度d，（共）聚合在由等式I定义的上包络限制的范围内进行，并且由等式IIin定义的下包络，其中变量具有以下含义：T H是最高的反应温度，单位°C; TL是最低反应温度（℃）; d'是待合成的（共）聚合物的密度d的数值。