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    METHOD FOR MAKING REDUCTION SENSITIVE NANO MICELLES
    2.
    发明申请
    METHOD FOR MAKING REDUCTION SENSITIVE NANO MICELLES 有权

    公开(公告)号：US20220054415A1

    公开(公告)日：2022-02-24

    申请号：US17139566

    申请日：2020-12-31

    申请人： JIANGNAN UNIVERSITY

    发明人： Caihua NI ,  Liping ZHANG ,  Xinxin Sang ,  Gang SHI

    IPC分类号： A61K9/107 ,  A61K31/704 ,  A61K47/32 ,  A61K9/19 ,  C08F220/58 ,  C08F220/38

    摘要： A method for making reduction sensitive nano micelles comprising: 1) dissolving taurine in distilled water, and adding sodium hydroxide solution; 2) dissolving acryloyl chloride in dichloromethane, reacting at 25° C.; dissolving lipoic acid in toluene and adding hydroxyethyl methacrylate, reacting at 85° C.; 3) dissolving N-acryloyltaurine and lipoic acid methacryloyloxyethyl ester and reacting at 60˜65° C., dropping the polymer solution into deionized water, adding dithiothreitol and reacting at 25˜30° C. to obtain reduction sensitive nano micelles after freeze-drying. The nano micelles have regular morphology and uniform distribution, and can be used as drug carriers for controlled release.

    A method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles
    3.
    发明申请
    A method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles 审中-公开

    公开(公告)号：US20200281865A1

    公开(公告)日：2020-09-10

    申请号：US16494993

    申请日：2018-12-03

    申请人： JIANGNAN UNIVERSITY

    发明人： Liping ZHANG ,  Caihua NI ,  Ren LIU ,  Dawei WANG ,  Gang SHI ,  Xinxin SANG ,  Xiaofeng XIA

    IPC分类号： A61K9/51 ,  A61K31/337 ,  A61K31/351

    摘要： The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

    Preparation Method for Charge Reversaland Reversibly Crosslinked Redox-Sensitive Nanomicelles
    4.
    发明申请
    Preparation Method for Charge Reversaland Reversibly Crosslinked Redox-Sensitive Nanomicelles 审中-公开

    公开(公告)号：US20190091147A1

    公开(公告)日：2019-03-28

    申请号：US15751577

    申请日：2017-04-27

    申请人： Jiangnan University

    发明人： Liping ZHANG ,  Ren LIU ,  Caihua NI ,  Yuanyuan Ding ,  Gang SHI ,  Xinxin Sang

    IPC分类号： A61K9/107 ,  A61K47/34 ,  C08J3/07 ,  C08J3/24 ,  C08G73/02

    摘要： Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N′-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved. The Nanomicelle of the present invention is expected to be a carrier of drugs for treating cancers.

    Method for preparing High Sensitivity Temperature Sensitive Reversible Color-Changing Microcapsule
    6.
    发明申请
    Method for preparing High Sensitivity Temperature Sensitive Reversible Color-Changing Microcapsule 有权

    公开(公告)号：US20230015116A1

    公开(公告)日：2023-01-19

    申请号：US17896220

    申请日：2022-08-26

    申请人： Jiangnan University

    发明人： Shaohai FU ,  Liping ZHANG ,  Jingjing LI ,  Chengcheng WANG ,  Xiaojun JIANG

    IPC分类号： C09B11/24 ,  C09B67/02 ,  B01J13/12

    摘要： The disclosure belongs to the technical field of material science, and particularly relates to a method for preparing a high sensitivity temperature sensitive reversible color-changing microcapsule. According to the method, a series of novel fluorane dyes are designed and synthesized, the color-changing performance can be achieved without a color developing agent, the fluorane dyes are compounded with a phase change material according to a certain proportion, a series of two-component reversible temperature sensitive color-changing dyes are prepared, and then a two-component reversible thermochromic microcapsule with good color performance and color-changing response performance is prepared by adopting a solvent evaporation method. The two-component reversible thermochromic microcapsule provided by the disclosure can effectively alleviate the color lag phenomenon of a traditional three-component thermochromic capsule.

    Method of Preparing Electric and Temperature Dual-control Bi-stable Color-changing Dyes and Microcapsules
    7.
    发明申请
    Method of Preparing Electric and Temperature Dual-control Bi-stable Color-changing Dyes and Microcapsules 有权

    公开(公告)号：US20210363355A1

    公开(公告)日：2021-11-25

    申请号：US17395793

    申请日：2021-08-06

    申请人： Jiangnan University

    发明人： Shaohai FU ,  Liping ZHANG ,  Chengcheng WANG ,  Mingfei SHENG ,  Anli TIAN

    IPC分类号： C09B67/02 ,  C09B9/00

    摘要： The disclosure discloses a method of preparing electric and temperature dual-control bi-stable color-changing dyes and microcapsules, belonging to the technical fields of fine chemicals and materials science. According to the disclosure, after an electrolyte, a leuco dye and an organic solid material are mixed according to 1:(2-10):(15-50), a series of electric and temperature dual-control bi-stable color-changing dye compounds having a color change temperature range of −5° C. to +80° C. can be prepared. The dye compounds change color under cooperative control of electricity and temperature, and can be continuously stable at a certain color change state according to different conditions, and finally achieve controllable color change conditions and controllable color change stable states. When being driven by voltage and temperature, the dual-control bi-stable color-changing microcapsules prepared according to the disclosure achieve controllable color change performance and color change stable states, and have the driving voltage being lower than 10 V (much lower than the human body safety voltage 36 V).

    Method of preparing degradable and environment responsive composite microgels
    8.
    发明申请
    Method of preparing degradable and environment responsive composite microgels 有权

    公开(公告)号：US20210299049A1

    公开(公告)日：2021-09-30

    申请号：US16928186

    申请日：2020-07-14

    申请人： JIANGNAN UNIVERSITY

    发明人： Caihua NI ,  Zhenle TIAN ,  Gang WANG ,  Liping ZHANG ,  Ren LIU

    IPC分类号： A61K9/19 ,  C08G63/06 ,  C08J3/075 ,  C08J3/14 ,  A61K31/704

    摘要： A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

    A method for preparation of hybrid amphiphilic star copolymer nano micelles
    9.
    发明申请
    A method for preparation of hybrid amphiphilic star copolymer nano micelles 审中-公开

    公开(公告)号：US20190110987A1

    公开(公告)日：2019-04-18

    申请号：US16159058

    申请日：2018-10-12

    申请人： JIANGNAN UNIVERSITY

    发明人： Liping ZHANG ,  Caihua NI ,  Ren LIU ,  He LIU ,  Xinyi DONG

    IPC分类号： A61K9/107 ,  C08G83/00 ,  A61K31/704 ,  C08G81/00

    摘要： Hybrid amphiphilic star copolymer nano micelles are prepared in the invention. Cage shaped octa(γ-aminopropyl) silsesquioxanes is selected as the inorganic part, and L-glutamic benzyl ester-five membered ring anhydride is ring-opening polymerized by the initiation of amino groups on the surface of cage shaped octa(γ-aminopropyl) silsesquioxanes, producing copolymers with cage shaped octa(γ-aminopropyl) silsesquioxanes as nucleus and poly (L-glutamic-benzyl ester) as arms. The copolymers reacts with monomethoxy poly (ethylene glycol) carboxylic acid by condensation. Finally, the benzyl groups in the side chains of poly (L-glutamic acid-benzyl ester) are converted into hydrazine groups by acylhydrazination to obtain hybrid amphiphilic star copolymer nano micelles. The micelles can load doxorubicin, they are safe to human body and have good application prospects.