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公开(公告)号：US20210402328A1
公开(公告)日：2021-12-30
申请号：US16915401
申请日：2020-06-29
申请人： Jacques Chammas
发明人： Jacques Chammas
摘要： The present invention provides an automated system and method to isolate nucleated blood cells from whole blood or bone marrow. A disc mounted to a centrifuge system with spinning rotor is used to manipulate cells by channeling fluids while subjected to high gravitational field. The disc embodies at least two axisymmetric processing stations connected by a circular channel. Each station contains multiple chambers connected by fluidic channels to controllably transfer fluids. First stage separation allows for the isolation of the buffy coat layer while the second stage separation utilizes gradient density fluids to isolate the targeted nucleated cells from the buffy coat layer in the spinning disc.
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公开(公告)号：USRE45315E1
公开(公告)日：2014-12-30
申请号：US10865554
申请日：2004-06-10
CPC分类号： F04B43/1292 , A61M1/0272 , A61M1/1039 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3672 , A61M2205/6072
摘要： A whole blood collection system includes an automated pump/control unit and an accompanying disposable blood set. When combined and connected to a source of anticoagulant, these elements allow automatic priming of the blood set with anticoagulant and automatic collection of anticoagulated blood product according to three different collection modes. The unit's pump and the blood set are specially designed to cooperate during the collection process to assure that the collected product has a precise blood to anticoagulant ratio. During the collection procedure, the pump/control unit automatically collects data relating to the procedure. Additional data specifically identifying components of the blood set, such as the blood collection bag, along with identification data on the donor's registration form may be scanned into the pump/controller unit by a scanner associated with the unit; this facilitates positive sample identification and tracking. At the end of the procedure, a printer in the pump/controller unit automatically prints out this information so that a detailed record is immediately available about the collected blood product, the procedure for collecting it and the source of the product, i.e., the donor.
摘要翻译： 全血采集系统包括自动化泵/控制单元和伴随的一次性血液装置。 当组合并连接到抗凝血剂源时，这些元件允许根据三种不同的收集模式用抗凝剂自动引发血液凝集物并自动收集抗凝血制品。 设备的泵和血液集合是专门设计在收集过程中配合，以确保收集的产品具有精确的血液和抗凝血比例。 在收集过程中，泵/控制单元自动收集有关过程的数据。 可以通过与该单元相关联的扫描仪将与血液集合的组分（例如采集袋）一起的附加数据连同供体登记表上的识别数据一起扫描到泵/控制器单元中; 这有助于阳性样本识别和跟踪。 在程序结束时，泵/控制器单元中的打印机自动打印出该信息，以便立即获得有关所收集的血液制品，收集的程序和产品来源的详细记录，即供体 。
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公开(公告)号：US20140158604A1
公开(公告)日：2014-06-12
申请号：US14105045
申请日：2013-12-12
申请人： Jacques Chammas
CPC分类号： A61M1/3679 , A61J1/10 , A61M1/0272 , A61M1/1621 , A61M1/3496 , A61M1/3633 , A61M1/3675 , B32B1/02 , B32B5/024 , B32B5/026 , B32B27/12 , B32B27/302 , B32B27/308 , B32B27/36 , B32B2260/021 , B32B2262/106 , B32B2264/108 , B32B2307/7145 , B32B2307/724 , B32B2307/7265 , B32B2439/80
摘要： Compositions, methods, devices and media are provided for platelet storage container that prevents bacterial growth in the stored platelets. The invention relates to blood bank needs in safely storing platelets collected from donors for more than 5 days at room temperature. The container is built with natural adsorbent media that have the characteristics in capturing and killing bacteria and viruses. The stored platelets are isolated from the natural adsorbent material during storage to preserve their medical quality and safety.
摘要翻译： 组合物，方法，装置和介质被提供用于防止存储的血小板中的细菌生长的血小板储存容器。 本发明涉及在室温下安全储存从供体收集的血小板超过5天的血库需求。 容器采用天然吸附剂介质制成，具有捕获和杀死细菌和病毒的特点。 储存的血小板在储存期间与天然吸附材料分离，以保持其医疗质量和安全性。
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公开(公告)号：US20110237418A1
公开(公告)日：2011-09-29
申请号：US13067425
申请日：2011-06-01
申请人： Jacques Chammas
发明人： Jacques Chammas
IPC分类号： B04B9/08
CPC分类号： B04B5/0442 , B04B7/00 , B04B11/06 , B04B2005/0464 , B04B2005/0485
摘要： A centrifuge system designed to receive a rotor having variable volumes adapted for collecting and centrifuging biological fluids. The centrifuge system encompasses a chuck that slides along the axis of rotation inside a rotating bucket. Thereby stretching or contracting the volume of the rotor.
摘要翻译： 离心机系统设计用于接收具有适于收集和离心生物流体的可变体积的转子。 离心机系统包括在旋转桶内沿着旋转轴线滑动的卡盘。 从而拉伸或收缩转子的体积。
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公开(公告)号：US20070257039A1
公开(公告)日：2007-11-08
申请号：US11407223
申请日：2006-04-20
申请人： Jacques Chammas
发明人： Jacques Chammas
IPC分类号： B65D25/04
CPC分类号： A01N1/02 , A01N1/0263
摘要： Metallic containers with high toughness characteristics are utilized to cryopreserve blood products and more particularly neonatal stem and progenitor cells at cryogenic temperatures. Metallic containers with high toughness and strength characteristics are durable at low temperatures and are capable to endure high stresses and impacts at −196° C. These containers are better fit to preserve blood products without compromising their sterility or their medical integrity. Methods for fabricating metallic containers are also disclosed.
摘要翻译： 具有高韧性特性的金属容器用于在低温下冷冻保存血液制品，特别是新生儿干细胞和祖细胞。 具有高韧性和强度特性的金属容器在低温下是耐用的，并且能够在-196℃下承受高应力和冲击。这些容器更适合于保护血液制品而不损害其无菌性或其医学完整性。 还公开了制造金属容器的方法。
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6.发明申请公开(公告)号：US20140323284A1
公开(公告)日：2014-10-30
申请号：US14271397
申请日：2014-05-06
申请人： Jacques Chammas
发明人： Jacques Chammas
IPC分类号： B04B9/14
CPC分类号： B04B9/14 , A61M1/0209 , A61M1/3693 , A61M1/3698 , A61M2205/331 , A61M2205/3569 , B04B5/0428 , B04B13/00 , B04B2009/143
摘要： A system for centrifugation and processing multi-units of blood simultaneously. The system having a plurality of equally spaced blood processing stations integrated to the rotor and spinning therewith around the axis of rotation. Each station is fit to receive a set of fluidly interconnected containers having blood for processing. Hydraulic means are used to automatically balance the rotor by having a mechanism to transfer fluid to special chambers on the processing stations in order to compensate for the weight variations of the multiple blood units mounted to the rotor. A Computer controls the centrifuge operations.
摘要翻译： 一种同时离心和处理多单位血液的系统。 该系统具有多个等间隔的血液处理站，其集成到转子上并围绕旋转轴线旋转。 每个站适合接收一组具有用于处理的血液的流体互连的容器。 液压装置用于通过具有将流体传送到处理站上的特殊室的机构来自动平衡转子，以补偿安装在转子上的多个血液单元的重量变化。 电脑控制离心机操作。
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公开(公告)号：US07998052B2
公开(公告)日：2011-08-16
申请号：US11368502
申请日：2006-03-07
申请人： Jacques Chammas
发明人： Jacques Chammas
IPC分类号： B04B1/02
CPC分类号： B04B5/0442 , B04B7/00 , B04B11/06 , B04B2005/0464 , B04B2005/0485
摘要： A rotor having variable volumes adapted for collecting and centrifuging biological fluids including an impermeable flexible body having a cylindrical shape with stretchable vertical walls and semi pliant base and a rigid circular member seamlessly joined to the top of the flexible body.
摘要翻译： 具有适于收集和离心生物流体的可变体积的转子，包括具有可伸缩垂直壁和半柔性基部的圆柱形形状的不可渗透柔性体，以及与柔性体的顶部无缝连接的刚性圆形构件。
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公开(公告)号：US20070213191A1
公开(公告)日：2007-09-13
申请号：US11368502
申请日：2006-03-07
申请人： Jacques Chammas
发明人： Jacques Chammas
IPC分类号： B04B7/12
CPC分类号： B04B5/0442 , B04B7/00 , B04B11/06 , B04B2005/0464 , B04B2005/0485
摘要： A rotor having variable volumes adapted for collecting and centrifuging biological fluids. The rotor includes an impermeable flexible body having a cylindrical shape with stretchable vertical walls and semi pliant base. The rotor includes a rigid circular member that is seamlessly joined to the top of the flexible body. The rigid cover defines an opening having a rotary seal that maintains a closed system inside a spinning rotor. The rotary seal permits a plurality of non-rotating conduits to pass through for controlling the flow in and out of the rotor while it is spinning. In a preferred embodiment, the rotor includes a Core to stabilize the rotating fluids inside the separation chamber, and/or includes a diverter to divert the fluid entering the rotor to the periphery of the separation chamber for better processing. When the rotor is inserted in the centrifuge, the rigid cover is fixed at the top of the centrifuge bucket. The base of the flexible body is firmly secured to the chuck by vacuum or mechanical interlock means. The chuck moves vertically down and up by pneumatics or electrical motor means embedded in the rotating centrifuge, while it is spinning. The base of the rotor moves vertically in conjunction with the chuck increasing or decreasing the volume of the processing chamber as the sidewall of the flexible body stretches or contracts. In another preferred embodiment the base of the flexible body is secured to the chuck by centrifugal means.
摘要翻译： 具有适于收集和离心生物流体的可变体积的转子。 转子包括具有可伸缩的垂直壁和半柔性基部的圆柱形的不可渗透的柔性体。 转子包括无缝地连接到柔性体的顶部的刚性圆形构件。 刚性盖限定了具有旋转密封件的开口，该旋转密封件将旋转转子内的封闭系统保持在内。 旋转密封件允许多个非旋转管道通过，用于控制在转子旋转时进入和离开转子的流体。 在优选实施例中，转子包括用于稳定分离室内的旋转流体的芯，和/或包括转向器，以将进入转子的流体转移到分离室的周边以便更好地处理。 当转子插入离心机时，刚性盖固定在离心斗的顶部。 柔性体的基部通过真空或机械互锁装置牢固地固定在卡盘上。 当旋转时，卡盘通过悬挂在旋转离心机中的气动或电动机装置垂直向下移动。 当柔性体的侧壁延伸或收缩时，转子的底部与卡盘一起垂直地移动增加或减小处理室的体积。 在另一优选实施例中，柔性体的底座通过离心机构固定在卡盘上。
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公开(公告)号：US5658231A
公开(公告)日：1997-08-19
申请号：US531409
申请日：1995-09-21
CPC分类号： B04B7/00 , Y10T279/247
摘要： A centrifugal chuck comprising a chuck housing and a plurality of fingers pivotally mounted around the outer perimeter of the chuck housing. Each finger includes a tip, adapted to receive the base portion of a separation bowl. The fingers are mounted to the chuck housing so that the tips can pivot in a generally radial direction. Rotation of the chuck urges each gripping finger against the bowl.
摘要翻译： 一种离心式卡盘，其包括卡盘壳体和围绕卡盘壳体的外周边可枢转地安装的多个指状物。 每个手指包括适于接收分离碗的基部的尖端。 指状物安装到卡盘壳体，使得尖端可以在大致径向方向上枢转。 卡盘的旋转将每个夹紧爪推向碗上。
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公开(公告)号：US4939495A
公开(公告)日：1990-07-03
申请号：US452865
申请日：1989-12-19
IPC分类号： H01H71/46
CPC分类号： H01H71/46 , H01H2071/086
摘要： A circuit breaker is shown having movable contacts carried by an operating member which moves between a circuit breaker contacts closed position and a circuit breaker contacts open position. An auxiliary switch has electrically conductive, flexible contact members adapted to engage an electrically conductive bridging shaft element carried by the operating member when the operating member is in one of its two positions to provide means for indicating the status of the circuit breaker.
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