公开(公告)号：US20100145469A1

公开(公告)日：2010-06-10

申请号：US12526223

申请日：2008-02-07

申请人： Jake Edward Barralet ,  Uwe Gbureck

发明人： Jake Edward Barralet ,  Uwe Gbureck

IPC分类号： A61F2/28 ,  B05D3/10

CPC分类号： A61F2/30767 ,  A61F2/2875 ,  A61F2/30771 ,  A61F2/3094 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30225 ,  A61F2002/30785 ,  A61F2002/3082 ,  A61F2002/30948 ,  A61F2002/30952 ,  A61F2002/30957 ,  A61F2002/30968 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2310/00179 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00281 ,  A61F2310/00293 ,  A61F2310/00329 ,  A61F2310/00592 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L27/10 ,  A61L27/306 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/64 ,  B28B1/00 ,  B28B1/001 ,  B28B7/465 ,  B29C64/165 ,  B29K2709/02 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C04B35/447 ,  C04B38/0054 ,  C04B2111/00181 ,  C04B2111/00836 ,  C04B2235/3208 ,  C04B2235/6026 ,  C04B38/0074

摘要： A bioceramic endoprosthesis includes a reservoir or deposition of a bioactive substance, such as an angiogenic growth factor, that can provide a biological function, such as vascularization of the endoprosthesis. Such a bioceramic can be prepared by a low temperature direct rapid prototyping inkjet printing system and process. Such a direct inkjet printing process includes the following: applying a ceramic powder to a substrate; inkjet printing a binder solution onto the ceramic powder so as to form a bound ceramic; inkjet printing a bioactive substance solution onto the bound ceramic, wherein the bioactive substance is printed on the bound ceramic at the low temperature (e.g., room temperature or within +/−10° C. of 25° C.); and repeating the process in order to form the bioceramic endoprosthesis.

摘要翻译： 生物陶瓷内置假体包括可以提供生物学功能（例如内用假体的血管化）的生物活性物质如血管生成生长因子的储存器或沉积物。 这种生物陶瓷可以通过低温直接快速成型喷墨印刷系统和工艺来制备。 这种直接喷墨印刷方法包括以下步骤：将陶瓷粉末施加到基材上; 将粘合剂溶液喷墨印刷到陶瓷粉末上以形成结合的陶瓷; 将生物活性物质溶液喷墨印刷到结合的陶瓷上，其中生物活性物质在低温（例如室温或+/- 10℃，25℃）下印刷在结合的陶瓷上; 并重复该过程以形成生物陶瓷内置假体。

公开(公告)号：USRE45561E1

公开(公告)日：2015-06-16

申请号：US12985939

申请日：2011-01-06

申请人： Jake Barralet ,  Uwe Gbureck ,  Ulrike Thull

发明人： Jake Barralet ,  Uwe Gbureck ,  Roger Thull

IPC分类号： C04B12/02 ,  A61L24/02 ,  A61L24/00 ,  A61L27/42

CPC分类号： A61L24/0063 ,  A61L27/425 ,  C04B12/02

摘要： In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:—(i) a powdered component, said powdered component having an average particle size d50 of less than 15 μm, and (ii) a calcium phosphate based powder, said powder having an average particle size d50 greater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:—(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least −30 mV.

摘要翻译： 在第一方面，本发明公开了一种自定型磷酸钙水泥，其包括：（i）粉末状成分，所述粉末成分的平均粒径d50小于15μm，和（ii）磷酸钙基粉末， 所述粉末的平均粒度d50大于粉末成分的平均粒径，所述粉末成分和所述磷酸钙粉末以足够的量悬浮在含有溶解的ζ电位增加添加剂的水中，以将悬浮颗粒的ζ电位增加到 至少30mV，并且其中选择ζ电位增加添加剂与不含ζ电位增加添加剂的相同磷酸钙水泥的凝固pH相容。 在第二方面，本发明公开了一种搁置稳定的酸性凝固水泥粉末，其包括：（i）磷酸钙基粉末，和（ii）粉末状化合物，其在添加水以形成水泥浆料时延迟所述水泥 凝固反应或将所得悬浮颗粒的ζ电位提高至至少-30mV。

公开(公告)号：US20060213398A1

公开(公告)日：2006-09-28

申请号：US10557833

申请日：2004-05-19

申请人： Jake Barralet ,  Uwe Gbureck ,  Roger Thull

发明人： Jake Barralet ,  Uwe Gbureck ,  Roger Thull

IPC分类号： C04B28/34

CPC分类号： A61L24/0063 ,  A61L27/425 ,  A61L2430/02

摘要： In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:—(i) a powdered component, said powdered component having an average particle size d50 of less than 15 μm, and (ii) a calcium phosphate based powder, said powder having an average particle size d50 greater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:—(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least −30 mV.

摘要翻译： 在第一方面，本发明公开了一种自设磷酸钙水泥，其包括：（i）粉末状成分，所述粉末成分的平均粒径d <50μm小于15μm，和（ ii）磷酸钙基粉末，所述粉末具有比粉末组分大的平均粒度d 50以下，所述粉末成分和所述磷酸钙基粉末悬浮在含有溶解的ζ电位的水中 增加足够量的添加剂以将悬浮颗粒的ζ电位增加至至少30mV，并且其中选择ζ电位增加添加剂与不具有ζ电位增加添加剂的相同磷酸钙水泥的凝固pH相容。 在第二方面，本发明公开了一种搁置稳定的酸性凝固水泥粉末，其包括：（i）磷酸钙基粉末，和（ii）粉末状化合物，其在添加水以形成水泥浆料时延迟所述水泥 凝固反应或将所得悬浮颗粒的ζ电位提高至至少-30mV。

公开(公告)号：US08540815B2

公开(公告)日：2013-09-24

申请号：US12918591

申请日：2009-02-18

申请人： Uwe Gbureck

发明人： Uwe Gbureck

IPC分类号： C04B12/02

CPC分类号： C04B28/34 ,  A61L24/0042 ,  A61L24/02 ,  B33Y70/00 ,  B33Y80/00 ,  C04B2111/00836 ,  C04B14/304 ,  C04B22/064 ,  C04B38/02 ,  C04B40/0028 ,  C04B2103/0009

摘要： The invention relates to a preparation for a magnesium ammonium phosphate cement. There is provided a preparation comprising (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0; (b) an ammonium salt; and (c) water; wherein the ammonium salt and the water can be present partially or completely as an aqueous solution of the ammonium salt.

摘要翻译： 本发明涉及磷酸镁镁水泥的制备方法。 提供了包含（a）式MgxCay（PO4）2Oz的磷酸镁镁，其中x + y @ 4，x> 1，y> 0，z = x + y-3和z> = 0的制剂; （b）铵盐; 和（c）水; 其中铵盐和水可以部分或全部作为铵盐的水溶液存在。

公开(公告)号：US20110028568A1

公开(公告)日：2011-02-03

申请号：US12918591

申请日：2009-02-18

申请人： Uwe Gbureck

发明人： Uwe Gbureck

IPC分类号： A61K47/02 ,  C04B12/02

CPC分类号： C04B28/34 ,  A61L24/0042 ,  A61L24/02 ,  B33Y70/00 ,  B33Y80/00 ,  C04B2111/00836 ,  C04B14/304 ,  C04B22/064 ,  C04B38/02 ,  C04B40/0028 ,  C04B2103/0009

摘要： The invention relates to a preparation for a magnesium ammonium phosphate cement. There is provided a preparation comprising (a) a magnesium calcium phosphate of the formula MgxCay(PO4)2Oz, wherein x+y≦4, x>1, y>0, z=x+y−3 and z≧0; (b) an ammonium salt; and (c) water; wherein the ammonium salt and the water can be present partially or completely as an aqueous solution of the ammonium salt.

摘要翻译： 本发明涉及磷酸镁镁水泥的制备方法。 提供了包含（a）式MgxCay（PO4）2Oz的磷酸镁镁，其中x + y和nlE; 4，x> 1，y> 0，z = x + y-3和z≥0的制剂; （b）铵盐; 和（c）水; 其中铵盐和水可以部分或全部作为铵盐的水溶液存在。

公开(公告)号：US07473312B2

公开(公告)日：2009-01-06

申请号：US10557833

申请日：2004-05-19

申请人： Jake Barralet ,  Uwe Gbureck ,  Roger Thull

发明人： Jake Barralet ,  Uwe Gbureck ,  Roger Thull

IPC分类号： C04B12/02

CPC分类号： A61L24/0063 ,  A61L27/425 ,  A61L2430/02

摘要： In a first aspect, the present invention discloses a self setting calcium phosphate cement comprising:—(i) a powdered component, said powdered component having an average particle size d50 of less than 15 μm, and (ii) a calcium phosphate based powder, said powder having an average particle size d50 greater than that of the powdered component, said powdered component and said calcium phosphate based powder being suspended in water containing a dissolved zeta potential increasing additive in sufficient quantity to increase the zeta potential of the suspended particles to at least 30 mV, and wherein the zeta potential increasing additive is chosen to be compatible with the setting pH of the same calcium phosphate cement without the zeta potential increasing additive. In a second aspect, the invention discloses a shelf-stable acidic setting cement powder comprising:—(i) a calcium phosphate based powder, and (ii) a powdered compound which, upon addition of water to form a cement paste, retards the cement setting reaction or increases the zeta potential of the resultant suspended particles to at least −30 mV.

摘要翻译： 在第一方面，本发明公开了一种自定型磷酸钙水泥，其包括：（i）粉末状成分，所述粉末成分的平均粒径d50小于15μm，和（ii）磷酸钙基粉末， 所述粉末的平均粒度d50大于粉末成分的平均粒径，所述粉末成分和所述磷酸钙粉末以足够的量悬浮在含有溶解的ζ电位增加添加剂的水中，以将悬浮颗粒的ζ电位增加到 至少30mV，并且其中选择ζ电位增加添加剂与不含ζ电位增加添加剂的相同磷酸钙水泥的凝固pH相容。 在第二方面，本发明公开了一种搁置稳定的酸性凝固水泥粉末，其包括：（i）磷酸钙基粉末，和（ii）粉末状化合物，其在添加水以形成水泥浆料时延迟所述水泥 凝固反应或将所得悬浮颗粒的ζ电位提高至至少-30mV。