公开(公告)号：US08318184B2

公开(公告)日：2012-11-27

申请号：US12968352

申请日：2010-12-15

申请人： James Allen Monn ,  Lourdes Prieto ,  Lorena Taboada Martinez ,  Carlos Montero Salgado ,  Bruce William Shaw

发明人： James Allen Monn ,  Lourdes Prieto ,  Lorena Taboada Martinez ,  Carlos Montero Salgado ,  Bruce William Shaw

IPC分类号： A61K31/35 ,  A61K39/00 ,  C07D211/78 ,  C07D249/04

CPC分类号： C07D249/10

摘要： The present invention provides novel mGlu2 agonists useful in the treatment of bipolar disorder, schizophrenia, depression, and generalized anxiety disorder.

摘要翻译： 本发明提供了可用于治疗双相情感障碍，精神分裂症，抑郁症和广泛性焦虑症的新颖的mGlu2激动剂。

公开(公告)号：US09296710B2

公开(公告)日：2016-03-29

申请号：US14123768

申请日：2012-06-07

申请人： Teresa Tse Ki Man ,  James Allen Monn ,  Carlos Montero Salgado ,  Lourdes Prieto ,  David Edward Tupper ,  Lesley Walton

发明人： Teresa Tse Ki Man ,  James Allen Monn ,  Carlos Montero Salgado ,  Lourdes Prieto ,  David Edward Tupper ,  Lesley Walton

IPC分类号： C07D249/04 ,  C07D249/12 ,  C07D249/14

CPC分类号： C07D249/14 ,  C07D249/04 ,  C07D249/12

摘要： The present invention provides novel mGlu2 agonists useful in the treatment of bipolar disorder, schizophrenia, and generalized anxiety disorder.

摘要翻译： 本发明提供了可用于治疗双相障碍，精神分裂症和广泛性焦虑症的新型mGlu2激动剂。

公开(公告)号：US20140113944A1

公开(公告)日：2014-04-24

申请号：US14123768

申请日：2012-06-07

申请人： Teresa Tse Ki Man ,  James Allen Monn ,  Carlos Montero Salgado ,  Lourdes Prieto ,  David Edward Tupper ,  Lesley Walton

发明人： Teresa Tse Ki Man ,  James Allen Monn ,  Carlos Montero Salgado ,  Lourdes Prieto ,  David Edward Tupper ,  Lesley Walton

IPC分类号： C07D249/14 ,  C07D249/12 ,  C07D249/04

CPC分类号： C07D249/14 ,  C07D249/04 ,  C07D249/12

摘要： The present invention provides novel mGlu2 agonists useful in the treatment of bipolar disorder, schizophrenia, and generalized anxiety disorder.

摘要翻译： 本发明提供了可用于治疗双相障碍，精神分裂症和广泛性焦虑症的新颖的mGlu2激动剂。

公开(公告)号：US08592590B2

公开(公告)日：2013-11-26

申请号：US13515407

申请日：2010-12-21

申请人： Lourdes Prieto ,  Lorena Taboada Martinez

发明人： Lourdes Prieto ,  Lorena Taboada Martinez

IPC分类号： C07D513/02 ,  A01N43/42

CPC分类号： C07D471/04

摘要： The present invention provides certain tetrahydrotriazolopyridine derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same. Formula (I) wherein R1 is hydrogen, fluoro, chloro, or methyl; and R2 is C4-CS branched alkyl.

摘要翻译： 本发明提供了一些四氢三唑并吡啶衍生物，其药物组合物，其使用方法及其制备方法。 式（I）其中R 1是氢，氟，氯或甲基; 并且R 2是C 4 -C 5支链烷基。

公开(公告)号：US20120252838A1

公开(公告)日：2012-10-04

申请号：US13515407

申请日：2010-12-21

申请人： Lourdes Prieto ,  Lorena Taboada Martinez

发明人： Lourdes Prieto ,  Lorena Taboada Martinez

IPC分类号： C07D471/04 ,  A61P25/18 ,  A61K31/437

CPC分类号： C07D471/04

摘要： The present invention provides certain tetrahydrotriazolopyridine derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same. Formula (I) wherein R1 is hydrogen, fluoro, chloro, or methyl; and R2 is C4-CS branched alkyl.

摘要翻译： 本发明提供了一些四氢三唑并吡啶衍生物，其药物组合物，其使用方法及其制备方法。 式（I）其中R 1是氢，氟，氯或甲基; 并且R 2是C 4 -C 5支链烷基。

公开(公告)号：US20050182088A1

公开(公告)日：2005-08-18

申请号：US10500516

申请日：2002-07-29

申请人： Peter Astles ,  Stephen Baker ,  Rowena Cube ,  Jose Martinez-Perez ,  Ana Mateo Herranz ,  Jean Vernier ,  Colin Dell ,  Sonia Gutierrez ,  Lourdes Prieto ,  Martine Keenan ,  Adam Sanderson ,  Colin Smith

发明人： Peter Astles ,  Stephen Baker ,  Rowena Cube ,  Jose Martinez-Perez ,  Ana Mateo Herranz ,  Jean Vernier ,  Colin Dell ,  Sonia Gutierrez ,  Lourdes Prieto ,  Martine Keenan ,  Adam Sanderson ,  Colin Smith

IPC分类号： A61K31/46 ,  A61K31/55 ,  C07D451/04 ,  C07D451/14 ,  C07D471/02 ,  A61K31/4745 ,  C07D453/04

CPC分类号： A61K31/46 ,  A61K31/55 ,  C07D451/04 ,  C07D451/14

摘要： The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.

摘要翻译： 本发明涉及通过促进神经递质如乙酰胆碱，多巴胺和去甲肾上腺素的释放来调节神经传递的化合物。 更具体地，本发明涉及能够调节乙酰胆碱受体的硫代桥连芳基化合物和包含这些化合物的药物组合物。 所公开的化合物可用于治疗中枢神经系统和自主神经系统的功能障碍。

公开(公告)号：US07148236B2

公开(公告)日：2006-12-12

申请号：US10500516

申请日：2002-07-29

申请人： Peter Charles Astles ,  Stephen Richard Baker ,  Rowena Villanueva Cube ,  Jose Antonio Martinez-Perez ,  Ana Isabel Mateo Herranz ,  Jean Michel Vernier ,  Colin Peter Dell ,  Sonia Gutierrez ,  Lourdes Prieto ,  Martine Keenan ,  Adam Jan Sanderson ,  Colin William Smith

发明人： Peter Charles Astles ,  Stephen Richard Baker ,  Rowena Villanueva Cube ,  Jose Antonio Martinez-Perez ,  Ana Isabel Mateo Herranz ,  Jean Michel Vernier ,  Colin Peter Dell ,  Sonia Gutierrez ,  Lourdes Prieto ,  Martine Keenan ,  Adam Jan Sanderson ,  Colin William Smith

IPC分类号： A01N43/42 ,  A61K31/44 ,  C07D451/02 ,  C07D451/04 ,  C07D451/06

CPC分类号： A61K31/46 ,  A61K31/55 ,  C07D451/04 ,  C07D451/14

摘要： The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.

摘要翻译： 本发明涉及通过促进神经递质如乙酰胆碱，多巴胺和去甲肾上腺素的释放来调节神经传递的化合物。 更具体地，本发明涉及能够调节乙酰胆碱受体的硫代桥连芳基化合物和包含这些化合物的药物组合物。 所公开的化合物可用于治疗中枢神经系统和自主神经系统的功能障碍。

公开(公告)号：US20070276138A1

公开(公告)日：2007-11-29

申请号：US11637223

申请日：2006-12-11

申请人： Dawn Brooks ,  Alan Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne Reifel-Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Martin ,  Maria Gonzales Garcia ,  Alicia Torrado ,  Rafael Crespo ,  Carlos Lamas-Peteira ,  Robert Ardecky ,  Maria Finger

发明人： Dawn Brooks ,  Alan Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne Reifel-Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Martin ,  Maria Gonzales Garcia ,  Alicia Torrado ,  Rafael Crespo ,  Carlos Lamas-Peteira ,  Robert Ardecky ,  Maria Finger

IPC分类号： C07D265/30 ,  C07C233/87 ,  C07D207/02 ,  C07D209/04 ,  C07D209/32 ,  C07D211/40 ,  C07D277/62 ,  C07D307/87 ,  C07D317/06 ,  C07D333/76 ,  C07D333/08 ,  C07D333/02 ,  C07D317/70 ,  C07D311/30 ,  C07D307/02 ,  C07D215/20 ,  C07D217/02 ,  C07D233/02 ,  C07D241/04 ,  C07D257/04

CPC分类号： C07D209/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C217/20 ,  C07C217/84 ,  C07C217/92 ,  C07C219/10 ,  C07C233/25 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/56 ,  C07C235/64 ,  C07C239/12 ,  C07C255/54 ,  C07C2601/08 ,  C07D209/08 ,  C07D213/30 ,  C07D215/14 ,  C07D217/02 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D277/64 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D307/79 ,  C07D307/83 ,  C07D307/91 ,  C07D307/93 ,  C07D311/30 ,  C07D317/20 ,  C07D317/22 ,  C07D317/54 ,  C07D317/64 ,  C07D333/16 ,  C07D333/76 ,  C07D335/02

摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W. R1 is —(CH2)n—CH(OR2)—(CH2)mE, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or —(CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1-C3-alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is —H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or —C(S)NR5R6. R3 is —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is —O—, —CH2—, —CH2CH2— or —CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

公开(公告)号：US07192982B2

公开(公告)日：2007-03-20

申请号：US10479262

申请日：2002-05-30

申请人： Dawn Alisa Brooks ,  Alan M. Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne-Reifel Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Alfredo Martin ,  Maria Rosario Gonzales Garcia ,  Alicia Torrado ,  Rafael Ferritto Crespo ,  Carlos Lamas-Peteira ,  Robert J. Ardecky ,  Maria Martin-Ortega Finger

发明人： Dawn Alisa Brooks ,  Alan M. Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne-Reifel Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Alfredo Martin ,  Maria Rosario Gonzales Garcia ,  Alicia Torrado ,  Rafael Ferritto Crespo ,  Carlos Lamas-Peteira ,  Robert J. Ardecky ,  Maria Martin-Ortega Finger

IPC分类号： A61K37/00 ,  C07C59/00

CPC分类号： C07D209/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C217/20 ,  C07C217/84 ,  C07C217/92 ,  C07C219/10 ,  C07C233/25 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/56 ,  C07C235/64 ,  C07C239/12 ,  C07C255/54 ,  C07C2601/08 ,  C07D209/08 ,  C07D213/30 ,  C07D215/14 ,  C07D217/02 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D277/64 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D307/79 ,  C07D307/83 ,  C07D307/91 ,  C07D307/93 ,  C07D311/30 ,  C07D317/20 ,  C07D317/22 ,  C07D317/54 ,  C07D317/64 ,  C07D333/16 ,  C07D333/76 ,  C07D335/02

摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R1 is (CH2)n—CH(OR2)—(CH2)mE1, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1–C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1–C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, —CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4–R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2

公开(公告)号：US20070054912A1

公开(公告)日：2007-03-08

申请号：US11595149

申请日：2006-11-09

申请人： Peter Astles ,  Stephen Baker ,  Rowena Cube ,  Jose Martinez-Perez ,  Ana Mateo Herranz ,  Jean Vernier ,  Colin Dell ,  Sonia Gutierrez ,  Lourdes Prieto ,  Martine Keenan ,  Adam Sanderson ,  Colin Smith

发明人： Peter Astles ,  Stephen Baker ,  Rowena Cube ,  Jose Martinez-Perez ,  Ana Mateo Herranz ,  Jean Vernier ,  Colin Dell ,  Sonia Gutierrez ,  Lourdes Prieto ,  Martine Keenan ,  Adam Sanderson ,  Colin Smith

IPC分类号： A61K31/53 ,  C07D471/02 ,  A61K31/519 ,  A61K31/498 ,  A61K31/4745

CPC分类号： A61K31/46 ,  A61K31/55 ,  C07D451/04 ,  C07D451/14

摘要： Compounds comprising an aza-bicyclic portion and an aromatic portion linked via an optionally oxidized sulphur atom are disclosed. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.

摘要翻译： 公开了包含氮杂双环部分和通过任选氧化的硫原子连接的芳族部分的化合物。 所公开的化合物可用于治疗中枢神经系统和自主神经系统的功能障碍。