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    MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS
    1.
    发明申请
    MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 有权
    MR光谱系统及其诊断方法，用于诊断阴性和非阴性椎间盘

    公开(公告)号：US20110087087A1

    公开(公告)日：2011-04-14

    申请号：US12579371

    申请日：2009-10-14

    申请人： James C. Peacock, III ,  John P. Claude ,  Paul H. Kane ,  Jeffrey C. Lotz

    发明人： James C. Peacock, III ,  John P. Claude ,  Paul H. Kane ,  Jeffrey C. Lotz

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/407 ,  A61B5/4514 ,  A61B5/4824 ,  A61B5/7203 ,  G01R33/34069 ,  G01R33/3415 ,  G01R33/4616 ,  G01R33/485 ,  G01R33/565 ,  G01R33/56527 ,  G06F19/00

    摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.

    摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR） 适用于给定的采集系列。 诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。 诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。 实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

    Implantable thermal treatment method and apparatus
    2.
    发明授权
    Implantable thermal treatment method and apparatus 有权
    可植入热处理方法和装置

    公开(公告)号：US07819826B2

    公开(公告)日：2010-10-26

    申请号：US10351450

    申请日：2003-01-23

    申请人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford ,  John P. O'Banion ,  James C. Peacock, III

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford ,  John P. O'Banion ,  James C. Peacock, III

    IPC分类号： A61B8/00

    CPC分类号： A61B18/04 ,  A61B8/56 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2018/00339 ,  A61B2090/374 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

    摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

    摘要翻译： 提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

    TRANSMUSCULAR LEFT VENTRICULAR CARDIAC STIMULATION LEADS AND RELATED SYSTEMS AND METHODS
    3.
    发明申请
    TRANSMUSCULAR LEFT VENTRICULAR CARDIAC STIMULATION LEADS AND RELATED SYSTEMS AND METHODS 审中-公开
    传导性左心室心脏刺激引线及相关系统及方法

    公开(公告)号：US20100069983A1

    公开(公告)日：2010-03-18

    申请号：US12436968

    申请日：2009-05-07

    申请人： James C. Peacock, III ,  Jonathan Langberg ,  Sean Patrick Whalen

    发明人： James C. Peacock, III ,  Jonathan Langberg ,  Sean Patrick Whalen

    IPC分类号： A61N1/05 ,  A61N1/362

    CPC分类号： A61N1/057 ,  A61N1/0573

    摘要： A cardiac stimulation system and method delivers a left ventricle stimulator from a right ventricle lead system in the right ventricle chamber, into a right side of an interventricular septum at a first location, and transmuscularly from the first location to a second location along the left side of the septum. The left ventricle stimulator is affixed at the second location for transmuscular stimulation of the left ventricle conduction system. A biventricular stimulation system further includes a right ventricle stimulator also delivered by the right ventricle lead system to the first location along the right side of the septum for right ventricular stimulation. An energy source is coupled to the transmuscular stimulation system, i.e., a pacemaker, and/or defibrillator, or to enhance contractility, and may be coupled directly or via “leadless” system(s). Various highly beneficial particular arrangements of stimulators and leads are further described.

    摘要翻译： 心脏刺激系统和方法将右心室引导系统的右心室刺激器的左心室刺激器输送到第一位置处的室间隔的右侧，并且从左侧的第一位置到第二位置 的隔膜。 左心室刺激器固定在第二位置，用于左心室传导系统的多重刺激。 双心室刺激系统还包括右心室刺激器，其也由右心室引导系统递送到沿隔膜右侧的第一位置用于右心室刺激。 能量源耦合到多重刺激系统，即起搏器和/或去纤颤器，或增强收缩性，并且可以直接或经由“无引线”系统耦合。 进一步描述了刺激器和引线的各种非常有益的特定布置。

    Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
    5.
    发明授权
    Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member 有权

    公开(公告)号：US06500174B1

    公开(公告)日：2002-12-31

    申请号：US09435283

    申请日：1999-11-05

    申请人： Mark A. Maguire ,  James C. Peacock, III

    发明人： Mark A. Maguire ,  James C. Peacock, III

    IPC分类号： A61B1818

    CPC分类号： A61B18/1492 ,  A61B2017/00243 ,  A61B2017/00256 ,  A61B2017/00318 ,  A61B2018/00023 ,  A61B2018/00065 ,  A61B2018/00136 ,  A61B2018/00214 ,  A61B2018/00238 ,  A61B2018/00369 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/044 ,  A61B2090/3966 ,  A61N7/02 ,  Y10T29/49169 ,  Y10T29/49888 ,  Y10T29/49982

    摘要： A medical balloon catheter assembly includes a balloon having a permeable region and a non-permeable region. The balloon is constructed at least in part from a fluid permeable tube such that the permeable region is formed from a porous material which allows a volume of pressurized fluid to pass from within a chamber formed by the balloon and into the permeable region sufficiently such that the fluid may be ablatively coupled to tissue engaged by the permeable region. The non-permeable region is adapted to substantially block the pressurized fluid from passing from within the chamber and outwardly from the balloon. The porous material may be a porous fluoropolymer, such as porous polytetrafluoroethylene, and the pores may be created by voids which are inherently formed between an interlocking node-fibril network which makes up the fluoropolymer. Such voids may be created according to one mode by expanding the fluoropolymer. The balloon may be formed such that the porous material extends along both the permeable and non-permeable regions. In one mode of this construction, the porous material is porous along the permeable region but is non-porous along the non-permeable region, such as for example by expanding only the permeable region in order to render sufficient voids in the node-fibril network to provide permeable pores in that section. The voids or pores in the porous material may also be provided along both permeable and non-permeable sections but are substantially blocked with an insulator material along the non-permeable section in order to prevent fluid from passing therethrough. The insulator material may be dip coated, deposited, or extruded with the porous material in order to fill the voids. The insulator material may in one mode be provided along the entire working length of the balloon and then selectively removed along the permeable section, or may be selectively exposed to only the non-permeable sections in order to fill the voids or pores there.

    Apparatus and method for selectively isolating a proximal anastomosis site from blood in an aorta
    7.
    发明授权
    Apparatus and method for selectively isolating a proximal anastomosis site from blood in an aorta 失效
    用于选择性分离近端吻合部位与主动脉血液的装置和方法

    公开(公告)号：US06234995B1

    公开(公告)日：2001-05-22

    申请号：US09191260

    申请日：1998-11-12

    申请人： James C. Peacock, III

    发明人： James C. Peacock, III

    IPC分类号： A61M2900

    CPC分类号： A61M25/0029 ,  A61B17/00234 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/00252 ,  A61B2017/1107 ,  A61B2017/12127 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2025/1052 ,  A61M2210/127

    摘要： A medical device system and method allows an arterial bypass graft to be proximally anastomosed to an aorta during a beating heart CABG procedure without substantial loss of blood by use of an endolumenal aorta isolation assembly provided along the distal end portion of an elongate catheter body. The aorta isolation assembly includes proximal and distal portions that are separated by an intermediate isolation region and that are adjustable to first and second extended positions, respectively, which are adapted to circumferentially engage the aortic wall and isolate upstream and downstream aspects of an exterior space between the elongate body and the aortic wall. Blood flowing within the aorta is thereby isolated from the proximal anastomosis site along the intermediate region and is shunted from an upstream region of the aorta, through the distal port into the flow lumen, proximally along the flow lumen, out from the flow lumen through the proximal port, and into a downstream region of the aorta. The assembly may also be used in a “stopped heart” cardiac bypass procedure, wherein a distal internal valve is coupled to the internal flow lumen along the elongate body between the distal and first proximal ports. A proximal internal valve is coupled to the internal flow lumen along the elongate body between the proximal port and a second proximal port.

    摘要翻译： 医疗装置系统和方法允许动脉旁路移植物在搏动心脏CABG程序期间向近端吻合到主动脉，而不会通过使用沿细长导管体的远端部分设置的腔内主动脉隔离组件而不会显着损失血液。 主动脉隔离组件包括近端部分和远端部分，其被中间隔离区域分开并且可分别调整到第一和第二延伸位置，第一和第二延伸位置适于周向地接合主动脉壁并隔离外部空间的上游和下游方面 细长体和主动脉壁。 在主动脉内流动的血液从而沿着中间区域从近端吻合部位分离，并且从主动脉的上游区域分流，通过远端口流入流腔，沿流腔向近侧从流腔流出，通过 近端口，并进入主动脉的下游区域。 该组件也可用于“停止的心脏”心脏旁路手术，其中远端内部阀门沿远端和第一近端口之间的细长体联接到内部流动腔。 近端内部阀沿近端口和第二近端口之间的细长主体联接到内部流动内腔。

    Endoscope propulsion system and method
    8.
    发明授权
    Endoscope propulsion system and method 失效
    内窥镜推进系统及方法

    公开(公告)号：US07708687B2

    公开(公告)日：2010-05-04

    申请号：US11140595

    申请日：2005-05-27

    申请人： M. Jonathan Bern ,  James C. Peacock, III

    发明人： M. Jonathan Bern ,  James C. Peacock, III

    IPC分类号： A61B1/00

    CPC分类号： A61B1/0016

    摘要： A system and method provides active propulsion of endoscopes along body lumens. The propulsion system can be attached to a commercially available endoscope, or be provide affixed together, and moves the endoscope in a lumen by pulling it forward. A rotatable toroidal wall, e.g. annular invaginated balloon, provides the propulsion. A drive assembly rotates the toroid while maintaining the toroid's position along the endoscope. The toroid is radially extended or inflated within the lumen to engage its outer surface to the lumen. The toroidal rotation tracks the lumen wall for propulsion. Stops maintain the rotating toroid's position on the endoscope. A helical screw within the toroid engages patterned protrusions around the toroid; screw rotation advances the protrusions to rotate the toroid wall. A fitted belt coupled to a groove in the toroid provides alternative actuation. Colonoscopy is substantially improved, reducing anesthesia and other requirements and costs, and improving safety.

    摘要翻译： 系统和方法提供内窥镜沿体腔的主动推进。 推进系统可以连接到市售的内窥镜，或者被提供固定在一起，并且通过向前拉它将内窥镜移动到内腔中。 可旋转的环形壁，例如 环形内陷的气球，提供推进。 驱动组件使环形线圈旋转，同时保持环形面沿着内窥镜的位置。 环形管在腔内径向延伸或膨胀以将其外表面接合到内腔。 环形旋转跟踪管腔壁进行推进。 停止保持内窥镜上旋转环形面的位置。 环形环内的螺旋螺钉与围绕环形线圈的图案化突起接合; 螺杆旋转使突起移动以旋转环形壁。 耦合到环形环中的凹槽的安装的带提供替代的致动。 结肠镜检查得到显着改善，减少麻醉等需求和成本，提高安全性。