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    Implantable thermal treatment method and apparatus
    1.
    发明授权
    Implantable thermal treatment method and apparatus 有权
    可植入热处理方法和装置

    公开(公告)号：US07819826B2

    公开(公告)日：2010-10-26

    申请号：US10351450

    申请日：2003-01-23

    申请人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford ,  John P. O'Banion ,  James C. Peacock, III

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford ,  John P. O'Banion ,  James C. Peacock, III

    IPC分类号： A61B8/00

    CPC分类号： A61B18/04 ,  A61B8/56 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2018/00339 ,  A61B2090/374 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

    摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

    摘要翻译： 提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

    System and method providing directional ultrasound therapy to skeletal joints
    2.
    发明授权
    System and method providing directional ultrasound therapy to skeletal joints 有权
    向骨骼关节提供定向超声治疗的系统和方法

    公开(公告)号：US07211055B2

    公开(公告)日：2007-05-01

    申请号：US10347164

    申请日：2003-01-15

    申请人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    IPC分类号： A61F7/00

    CPC分类号： A61N7/02 ,  A61B18/04 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0021 ,  A61N2007/003 ,  A61N2007/0056 ,  A61N2007/0078

    摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

    摘要翻译： 提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

    Method for providing directional therapy to skeletal joints
    3.
    发明授权
    Method for providing directional therapy to skeletal joints 有权
    为骨骼关节提供定向治疗的方法

    公开(公告)号：US08915949B2

    公开(公告)日：2014-12-23

    申请号：US12781689

    申请日：2010-05-17

    申请人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    IPC分类号： A61N7/00 ,  A61N7/02 ,  A61B18/04 ,  A61B17/00 ,  A61B19/00

    CPC分类号： A61N7/02 ,  A61B18/04 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0021 ,  A61N2007/003 ,  A61N2007/0056 ,  A61N2007/0078

    摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.

    摘要翻译： 提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

    METHOD FOR PROVIDING DIRECTIONAL THERAPY TO SKELETAL JOINTS
    4.
    发明申请
    METHOD FOR PROVIDING DIRECTIONAL THERAPY TO SKELETAL JOINTS 有权
    用于向骨骼接合提供方向治疗的方法

    公开(公告)号：US20110022133A1

    公开(公告)日：2011-01-27

    申请号：US12781689

    申请日：2010-05-17

    申请人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will Nau ,  David S. Bradford

    IPC分类号： A61F7/00

    CPC分类号： A61N7/02 ,  A61B18/04 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0021 ,  A61N2007/003 ,  A61N2007/0056 ,  A61N2007/0078

    摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.

    摘要翻译： 提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

    IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS
    6.
    发明申请
    IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS 有权
    可植入热处理方法和装置

    公开(公告)号：US20110087314A1

    公开(公告)日：2011-04-14

    申请号：US12898401

    申请日：2010-10-05

    申请人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will H. Nau, JR. ,  David S. Bradford

    发明人： Chris J. Diederich ,  Jeffrey C. Lotz ,  Will H. Nau, JR. ,  David S. Bradford

    IPC分类号： A61F7/12

    CPC分类号： A61B18/04 ,  A61B8/56 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00261 ,  A61B2018/00339 ,  A61B2090/374 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

    摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.

    摘要翻译： 提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

    ARTICULATING INSTRUMENTATION FOR DYNAMIC SPINAL STABILIZATION
    9.
    发明申请
    ARTICULATING INSTRUMENTATION FOR DYNAMIC SPINAL STABILIZATION 审中-公开
    用于动态脊柱稳定的仪器仪表

    公开(公告)号：US20080243194A1

    公开(公告)日：2008-10-02

    申请号：US12055531

    申请日：2008-03-26

    申请人： Jeffrey C. Lotz ,  David S. Bradford

    发明人： Jeffrey C. Lotz ,  David S. Bradford

    IPC分类号： A61F5/00 ,  A61B17/70 ,  A61B17/04

    CPC分类号： A61B17/70 ,  A61B17/7023 ,  A61B90/03

    摘要： Dynamic stabilization apparatus and methods in the context of a spinal implant configured to constrain intervertebral movement, where the constraint is meant to eliminate unwanted, non-physiologic motions. The system provides dynamic stability to motion in a compromised spinal joint by allowing motion along a centrode of the instant axis of rotation (IAR) that substantially approximates the normal centrode for the respective spinal joint. The system and method is adapted to provide stabilized motion in a spinal joint such that the IAR shifts cephalad during typical flexion ranges beyond a normal resting range of motion, and shifts posteriorly during typical extension ranges beyond the normal resting range of motion.

    摘要翻译： 在脊柱植入物的上下文中的动态稳定装置和方法被配置成约束椎间动作，其中约束意在消除不需要的非生理运动。 该系统通过允许沿着基本上接近相应脊柱关节的正常中心的瞬时旋转轴线（IAR）的中心运动来提供在受损脊椎关节中的运动的动态稳定性。 该系统和方法适于在脊柱关节中提供稳定的运动，使得IAR在典型的屈曲范围内移动头部，超过正常的静止运动范围，并且在超出正常的静止运动范围的典型延伸范围内向后移动。

    SYSTEMS, COMPOSITIONS, AND METHODS FOR LOCAL IMAGING AND TREATMENT OF PAIN
    10.
    发明申请
    SYSTEMS, COMPOSITIONS, AND METHODS FOR LOCAL IMAGING AND TREATMENT OF PAIN 有权
    用于局部成像和治疗疼痛的系统，组合物和方法

    公开(公告)号：US20090030308A1

    公开(公告)日：2009-01-29

    申请号：US12053379

    申请日：2008-03-21

    申请人： David S. Bradford ,  Jeffrey C. Lotz

    发明人： David S. Bradford ,  Jeffrey C. Lotz

    IPC分类号： A61B18/18 ,  A61K101/02 ,  A61K51/10 ,  A61K49/00 ,  A61N7/00 ,  A61B6/00 ,  A61K49/22 ,  A61K49/06 ,  A61B18/08

    CPC分类号： A61B6/506 ,  A61B5/4041 ,  A61B5/4824 ,  A61B18/14 ,  A61B2018/00339 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61K49/0002 ,  A61K51/1096 ,  A61M5/007 ,  A61M5/1723 ,  A61M2230/005 ,  A61N7/02

    摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor.

    摘要翻译： 疼痛因素用传递到体内的靶向药物或标记进行标记。 标记的疼痛因子以适当的成像工具以允许选择性识别和定位疼痛源或传播区域的方式成像。 标记的疼痛因子允许成像中的空间分化足以指定疼痛的位置，以便驱动治疗决定和技术以治疗疼痛。 以这种方式标记和成像的疼痛因子可包括神经因子，血管因子，细胞因子和炎症因子中的一种或多种。 标记的标记可以包括例如放射性材料（例如氚化或碘化分子）或其它材料，例如金属（例如金）纳米颗粒。 可以使用中间结合材料，例如双特异性抗体。 系统和方法的治疗组件包括例如局部能量递送或消融治疗，或局部药物或其它化学物质递送。 选择性地由靶向药物结合的含有疼痛因子的位置被选择性地用定向能量处理到含有与疼痛因子结合的靶向药剂的区域中。