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44 条记录 (耗时 0.057 秒)

    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
    2.
    发明授权
    DNA encoding a human serotonin receptor (5-HT4B) and uses thereof 有权
    编码人5-羟色胺受体（5-HT4B）的DNA及其用途

    公开(公告)号：US06300087B1

    公开(公告)日：2001-10-09

    申请号：US09450797

    申请日：1999-11-29

    申请人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    发明人： Jonathan A. Bard ,  Theresa Branchek ,  Richard L. Weinshank

    IPC分类号： C12N1518

    CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/10 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/70571

    摘要： This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor and an isolated nucleic acid molecule encoding a human 5-HT4B receptor, an isolated protein which is mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT4B receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT4B receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT4B receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT4B receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT4B receptor, pharmaceutical compounds related to the human 5-HT4B receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT4B receptor.

    摘要翻译： 本发明提供编码哺乳动物5-HT4B受体的分离的核酸分子和编码人5-HT4B受体的分离的核酸分子，其是哺乳动物5-HT4B受体的分离的蛋白质，载体包含编码哺乳动物的分离的核酸分子 5-HT4B受体的载体，包含编码人5-HT4B受体的分离的核酸分子的载体，包含这种载体的哺乳动物细胞，针对5-HT4B受体的抗体，用于检测编码哺乳动物或人5- HT4B受体，与编码哺乳动物或人类5-HT4B受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT4B受体相关的药物化合物。 本发明还提供了用于确定配体结合，检测表达，药物筛选和用于减轻与人5-HT4B受体相关的异常的治疗的方法。

    Methods for identifying a compound that binds to a human 5-HT 1E receptor
    3.
    发明授权
    Methods for identifying a compound that binds to a human 5-HT 1E receptor 失效
    用于鉴定结合人5-HT 1E受体的化合物的方法

    公开(公告)号：US5786155A

    公开(公告)日：1998-07-28

    申请号：US542358

    申请日：1995-10-12

    申请人： Richard L. Weinshank ,  Theresa Branchek ,  Paul R. Hartig

    发明人： Richard L. Weinshank ,  Theresa Branchek ,  Paul R. Hartig

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  G01N33/567

    CPC分类号： A61K49/0004 ,  A61K47/48276 ,  C07K14/70571 ,  A61K38/00

    摘要： This invention provides an isolated nucleic acid molecule encoding a human 5-HT.sub.1E receptor, an isolated protein which is a human 5-HT.sub.1E receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT.sub.1E receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT.sub.1E receptor, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT.sub.1E receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT.sub.1E receptor, pharmaceutical compounds related to human 5-HT.sub.1E receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT.sub.1E receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT.sub.1E receptor.

    摘要翻译： 本发明提供编码人5-HT1E受体的分离的核酸分子，作为人5-HT1E受体的分离蛋白，包含编码人5-HT1E受体的分离的核酸分子的载体，包含该载体的哺乳动物细胞，抗体 针对人5-HT1E受体，可用于检测编码人5-HT1E受体的核酸的核酸探针，与编码人5-HT1E受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT1E受体相关的药物化合物 -HT1E受体和表达DNA的正常或突变型人类5-HT1E受体的非人类转基因动物。 本发明进一步提供了确定配体结合，检测表达，药物筛选和涉及人5-HT1E受体的治疗方法。

    DNA encoding a human 5-HT.sub.1E receptor and uses thereof
    4.
    发明授权
    DNA encoding a human 5-HT.sub.1E receptor and uses thereof 失效
    编码人5-HT1E受体的DNA及其用途

    公开(公告)号：US5476782A

    公开(公告)日：1995-12-19

    申请号：US370542

    申请日：1995-01-09

    申请人： Richard L. Weinshank ,  Theresa Branchek ,  Paul R. Hartig

    发明人： Richard L. Weinshank ,  Theresa Branchek ,  Paul R. Hartig

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  C07H21/04 ,  C12N15/12

    CPC分类号： A61K49/0004 ,  A61K47/48276 ,  C07K14/70571 ,  A61K38/00

    摘要： This invention provides an isolated nucleic acid molecule encoding a human 5-HT.sub.1E receptor, an isolated protein which is a human 5-HT.sub.1E receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT.sub.1E receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT.sub.1E receptor, nucleic acid probes useful for detecting nucleic acid encoding human 5-H.sub.1E receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT.sub.1E receptor, pharmaceutical compounds related to human 5-HT.sub.1E receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT.sub.1E receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human 5-HT.sub.1E receptor.

    摘要翻译： 本发明提供编码人5-HT1E受体的分离的核酸分子，作为人5-HT1E受体的分离蛋白，包含编码人5-HT1E受体的分离的核酸分子的载体，包含该载体的哺乳动物细胞，抗体 用于检测编码人5-H1E受体的核酸的核酸探针，与编码人5-HT1E受体的核酸分子的任何序列互补的反义寡核苷酸，与人5-HT1E受体相关的药物化合物 -HT1E受体和表达DNA的正常或突变型人类5-HT1E受体的非人类转基因动物。 本发明进一步提供了确定配体结合，检测表达，药物筛选和涉及人5-HT1E受体的治疗方法。

    Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
    7.
    发明授权
    Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
    用于人类下丘脑非典型神经肽Y /肽YY受体（Y5）的化合物改变进食行为的方法

    公开(公告)号：US06645774B1

    公开(公告)日：2003-11-11

    申请号：US09447907

    申请日：1999-11-23

    申请人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    发明人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    IPC分类号： G01N33566

    CPC分类号： A61K31/137 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70571 ,  C12Q1/6883

    摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.

    摘要翻译： 本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。 这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。 一种这样的化合物具有以下结构：另外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含这种载体的细胞，针对 Y5受体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变型Y5受体的DNA的非人类转基因动物。

    DNA encoding a glycine transporter and uses thereof
    8.
    发明授权
    DNA encoding a glycine transporter and uses thereof 失效
    Dna编码甘氨酸转运蛋白并使用该方法

    公开(公告)号：US6127131A

    公开(公告)日：2000-10-03

    申请号：US84813

    申请日：1998-05-26

    申请人： Kelli E. Smith ,  Laurence A. Borden ,  Theresa Branchek ,  Paul R. Hartig ,  Richard L. Weinshank

    发明人： Kelli E. Smith ,  Laurence A. Borden ,  Theresa Branchek ,  Paul R. Hartig ,  Richard L. Weinshank

    IPC分类号： A61K38/00 ,  C07K14/47 ,  G01N33/53 ,  G01N33/567

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00

    摘要： This invention provides isolated nucleic acid molecules encoding a mammalian glycine transporter, isolated nucleic acid molecules encoding a human glycine transporter, isolated proteins which are mammalian glycine transporter proteins, isolated proteins which are human glycine transporter proteins, vectors comprising isolated nucleic acid molecules encoding a mammalian or a human glycine transporter, mammalian cells comprising such vectors, antibodies directed to a mammamlian glycine transporter, antibodies directed to a human glycine transporter, nucleic acid probes useful for detecting nucleic acid encoding mammalian glycine transporter, nucleic acid probes useful for detecting nucleic acid encoding human glycine transporter, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian glycine transporter, antisense oligonucleotides complementary to any sequences of a nucleic said molecule which encodes a human glycine transporter, pharmaceutical compounds related to mammalian glycine transporter and nonhuman transporter, pharmaceutical compounds related to human glycine transporter and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human glycine transorter. This invention also provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with mammalian glycine transporter. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human glycine transporter.