专利检索 ap:("James M. Chen" OR "Xiaowu Chen" OR "Aesop Cho" OR "Lee S. Chong" OR "Maria Fardis" OR "Thorsten Kirschberg" OR "Steven Krawczyk" OR "Hyung-Jung Pyun" OR "William J. Watkins") AND inv:"Aesop Cho" 第 1 页

1.

发明申请
PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES 审中-公开
标题翻译：用于治疗代谢性疾病的磷酸酯类似物

公开(公告)号：US20090131372A1

公开(公告)日：2009-05-21

申请号：US12145329

申请日：2008-06-24

申请人： James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins

发明人： James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins

IPC分类号： A61K31/675 , C07F9/38 , A61P3/00

CPC分类号： A61K31/66 , A61K31/675 , A61K47/548

摘要： The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及具有用于治疗代谢性疾病和/或病症（例如糖尿病和高胆固醇血症）的活性的磷取代的化合物，以及含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备此类化合物。

2.

发明授权
Phosphonate analogs for treating metabolic diseases 失效
标题翻译：用于治疗代谢性疾病的膦酸酯类似物

公开(公告)号：US07407965B2

公开(公告)日：2008-08-05

申请号：US10832817

申请日：2004-04-26

申请人： James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins

发明人： James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Steven Krawczyk , Hyung-Jung Pyun , William J. Watkins

IPC分类号： A61K31/505 , C07F9/02

CPC分类号： A61K31/66 , A61K31/675 , A61K47/548

摘要： The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及具有用于治疗代谢性疾病和/或病症（例如糖尿病和高胆固醇血症）的活性的磷取代的化合物，以及含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备此类化合物。

3.

发明申请
ANTI-CANCER PHOSPHONATE ANALOGS 审中-公开
标题翻译：抗癌剂磷酸酯类似物

公开(公告)号：US20100022467A1

公开(公告)日：2010-01-28

申请号：US12202719

申请日：2008-09-02

申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

IPC分类号： A61K31/7076 , C07H19/20 , A61P35/00

CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04

摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

4.

发明授权
Anti-cancer phosphonate analogs 失效
标题翻译：抗癌膦酸类似物

公开(公告)号：US07452901B2

公开(公告)日：2008-11-18

申请号：US10833293

申请日：2004-04-26

申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Steven Krawczyk , Christopher P. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang

IPC分类号： A61K31/44 , C07D239/00

CPC分类号： A61K31/7076 , A61K31/675 , A61K31/7072 , A61K47/548 , C07H19/04

摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

5.

发明申请
PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY 审中-公开
标题翻译：具有免疫调节活性的磷酸盐化合物

公开(公告)号：US20090227543A1

公开(公告)日：2009-09-10

申请号：US12166145

申请日：2008-07-01

申请人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan

发明人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Alan X. Huang , Thorsten Kirschberg , Christopher P. Lee , Richard L. Mackman , Peter H. Nelson , Hyung-Jung Pyun , Adrian S. Ray , William J. Watkins , Jennifer R. Zhang , Sundaramoorthi Swaminathan

IPC分类号： A61K31/665 , C07F9/655

CPC分类号： A61K47/548 , A61K47/542

摘要： The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

6.

发明授权
Antiviral phosphonate analogs 有权
标题翻译：抗病毒膦酸酯类似物

公开(公告)号：US07429565B2

公开(公告)日：2008-09-30

申请号：US10832815

申请日：2004-04-26

申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang

发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang

IPC分类号： A61K38/00 , C07D267/22

CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465

摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

7.

发明申请
ANTIVIRAL PHOSPHONATE ANALOGS 审中-公开
标题翻译：抗磷酸酯类似物

公开(公告)号：US20110288053A1

公开(公告)日：2011-11-24

申请号：US13187293

申请日：2011-07-20

申请人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Heolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoothi Swaninathan , William J. Watkins , Jenneifer Zhang

发明人： Constantine G. Boojamra , Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Heolun Jin , Ralph F. Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoothi Swaninathan , William J. Watkins , Jenneifer Zhang

IPC分类号： A61K31/675 , A61K31/665 , A61K31/52 , A61K31/422 , C07D307/87 , A61P31/12 , C07F9/02 , C07D473/34 , C07D413/12 , C07F9/06 , C12N5/02 , A61K31/365

CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465

摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

8.

发明授权
Inosine monophosphate dehydrogenase inhibitory phosphonate compounds 失效
标题翻译：肌苷单磷酸脱氢酶抑制性膦酸酯化合物

公开(公告)号：US07427636B2

公开(公告)日：2008-09-23

申请号：US10832829

申请日：2004-04-26

申请人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Hyung-Jung Pyun , William J. Watkins , Jennifer R. Zhang

发明人： Carina Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Thorsten Kirschberg , Hyung-Jung Pyun , William J. Watkins , Jennifer R. Zhang

IPC分类号： A61K31/42 , C07D263/30

CPC分类号： C07F9/4075 , A61K31/662 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561

摘要： The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的IMPDH抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。