公开(公告)号：US06228050B1

公开(公告)日：2001-05-08

申请号：US09303006

申请日：1999-04-30

申请人： James M. Olsen ,  Reginald D. Robinson ,  Chris Christiansen ,  Paul Kratoska

发明人： James M. Olsen ,  Reginald D. Robinson ,  Chris Christiansen ,  Paul Kratoska

IPC分类号： A61M1100

CPC分类号： A61M5/14276 ,  A61M39/22 ,  A61M2209/045

摘要： The displacement of refill valves in an implantable drug delivery device is reduced to permit the housings of a drug delivery device to remain compact in size while permitting reservoirs of increased depth to be used. In a preferred embodiment, a collapsible link is provided as a telescoping member incorporating a coil spring. As the valve is pulled into contact with its seat, a detectable pressure increase is sensed in the refill device. In accordance with the invention, as the drug supply contained in the reservoir depletes, the reservoir surface moves towards a collapsed position, compressing the coil spring and eventually contacting the valve stem, thereby lifting the valve from its seat. By virtue of telescoping link, the valve stem length and therefore the valve travel may be reduced as compared to prior art devices, thus eliminating the need for increased housing depth when deeper reservoirs are used. The collapsible link may be comprised of a second spring combined with a telescoping link. The second spring is situated on a side of the valve opposite the telescoping link, thereby providing a downward force on the valve and valve stem. As an other alternative, the invention provides a lever arm for actuating the refill valve. A pivot for the lever arm is situated near the refill valve and a distal end of the lever arm maintained in contact with the reservoir surface using a spring bias. An intermediate portion of the lever arm engages the valve stem. Thus, as the reservoir surface moves towards the collapsed position, the displacement of the valve is a fraction of the displacement of the distal end of the lever arm.

摘要翻译： 可植入药物输送装置中的再填充阀的位移被减少以允许药物输送装置的壳体保持紧凑的尺寸，同时允许使用增加深度的储存器。 在优选实施例中，可折叠连杆被提供为包括螺旋弹簧的伸缩构件。 当阀被拉动与其座位接触时，在再填充装置中感测到可检测的压力增加。 根据本发明，随着储存器中所含的药物供给消耗，贮存器表面向收缩位置运动，压缩螺旋弹簧并最终接触阀杆，从而将阀从其座上提起。 通过伸缩连杆，与现有技术的装置相比，阀杆长度和阀行程可以减小，从而在使用更深的储存器时消除了增加壳体深度的需要。 可折叠连杆可以由与伸缩连杆组合的第二弹簧构成。 第二弹簧位于与伸缩连杆相对的阀的一侧，从而在阀和阀杆上提供向下的力。 作为另一种替代方案，本发明提供一种用于致动再填充阀的杠杆臂。 用于杠杆臂的枢轴位于补充阀附近，并且杠杆臂的远端使用弹簧偏压保持与储存器表面接触。 杠杆臂的中间部分与阀杆接合。 因此，当储存器表面朝向折叠位置移动时，阀的位移是杠杆臂的远端的位移的一部分。

公开(公告)号：US09724784B2

公开(公告)日：2017-08-08

申请号：US12401239

申请日：2009-03-10

申请人： Reginald D. Robinson ,  David D. Differding ,  James A. Johnson ,  Bernard Q. Li ,  Gerald G. Lindner ,  Brad C. Tischendorf ,  Andrew J. Thom

发明人： Reginald D. Robinson ,  David D. Differding ,  James A. Johnson ,  Bernard Q. Li ,  Gerald G. Lindner ,  Brad C. Tischendorf ,  Andrew J. Thom

IPC分类号： B23K26/00 ,  B23K26/20 ,  B23K26/21 ,  A61N1/375 ,  B29C65/14 ,  B29C65/16 ,  B29C65/48 ,  B29C65/00 ,  B29C35/08 ,  G02B6/38 ,  G02B6/42

CPC分类号： B23K26/206 ,  A61N1/375 ,  B23K26/21 ,  B29C65/14 ,  B29C65/1406 ,  B29C65/16 ,  B29C65/4845 ,  B29C66/54 ,  B29C2035/0827 ,  G02B6/3897 ,  G02B6/4248

摘要： In general, the disclosure is directed toward transmitting radiant energy across a boundary of a medical device via an optical feedthrough. A system for transmitting radiant energy across a boundary of a medical device includes a first functional module of a medical device, a second functional module of the medical device, an optical feedthrough assembly coupled to the first functional module, and a radiant energy source that emits a beam through the optical feedthrough assembly to perform a manufacturing process on the first functional module and the second functional module.

公开(公告)号：US09737660B2

公开(公告)日：2017-08-22

申请号：US13217981

申请日：2011-08-25

申请人： Reginald D. Robinson ,  Mary E. Robischon ,  Bernard Q. Li ,  Irfan Z. Ali ,  Steven R. Christenson ,  Keith A. Miesel

发明人： Reginald D. Robinson ,  Mary E. Robischon ,  Bernard Q. Li ,  Irfan Z. Ali ,  Steven R. Christenson ,  Keith A. Miesel

IPC分类号： A61M5/168 ,  A61M39/22 ,  A61M5/142

CPC分类号： A61M5/16827 ,  A61M5/14276 ,  A61M5/1684 ,  A61M39/223 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/1003

摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the valve to open and close the first fluid pathway and to open and close the second fluid pathway.

公开(公告)号：US06485464B1

公开(公告)日：2002-11-26

申请号：US09560173

申请日：2000-04-28

申请人： Steven R. Christenson ,  Reginald D. Robinson ,  Kenneth T. Heruth ,  James Randall ,  Manfred K. L{overscore (u)}edi ,  Christian Pèclat

发明人： Steven R. Christenson ,  Reginald D. Robinson ,  Kenneth T. Heruth ,  James Randall ,  Manfred K. L{overscore (u)}edi ,  Christian Pèclat

IPC分类号： F04B4312

CPC分类号： A61M5/14276 ,  A61M5/14232

摘要： An implantable drug infusion device includes a pumphead assembly and a motor assembly operably connected to the pumphead assembly. The motor assembly is adjacent to and laterally offset from the pumphead assembly, advantageously reducing the overall height of the implantable drug infusion device.

摘要翻译： 可植入药物输注装置包括可操作地连接到泵头组件的泵头组件和马达组件。 马达组件与泵头组件相邻并且横向偏移，有利地减小了可植入药物输注装置的整体高度。

公开(公告)号：US08192418B2

公开(公告)日：2012-06-05

申请号：US12401267

申请日：2009-03-10

申请人： Reginald D. Robinson ,  David D. Differding ,  James A. Johnson ,  Bernard Q. Li ,  Gerald G. Lindner ,  Brad C. Tischendorf ,  Andrew J. Thom

发明人： Reginald D. Robinson ,  David D. Differding ,  James A. Johnson ,  Bernard Q. Li ,  Gerald G. Lindner ,  Brad C. Tischendorf ,  Andrew J. Thom

IPC分类号： A61M5/32

CPC分类号： A61M5/14276 ,  A61M5/1407 ,  A61M39/04 ,  A61M2205/368

摘要： In general, the disclosure is directed toward releasing material within a medical device via an optical feedthrough. A system for releasing material with a medical device comprises a cup that holds a material, wherein the cup includes a discharge port, a seal disc that seals the material within the cup, an optical feedthrough assembly coupled to the cup, a shell that defines a chamber within a medical device, wherein the optical feedthrough assembly is coupled to the shell, and a radiant energy source that shines a beam through the optical feedthrough assembly to puncture the seal disc to allow the material to enter the chamber via the discharge port.

摘要翻译： 通常，本公开涉及经由光学馈通释放医疗装置内的材料。 用于使用医疗装置释放材料的系统包括保持材料的杯，其中杯包括排出口，密封杯内的材料的密封盘，耦合到杯的光学馈通组件， 其中所述光学馈通组件耦合到所述壳体，以及辐射能源，其将光束照射通过所述光学馈通组件以刺穿所述密封盘以允许所述材料经由所述排出口进入所述腔室。

公开(公告)号：US20120053514A1

公开(公告)日：2012-03-01

申请号：US13217981

申请日：2011-08-25

申请人： Reginald D. Robinson ,  Mary E. Robischon ,  Bernard Q. Li ,  Irfan Z. Ali ,  Steven R. Christenson ,  Keith A. Miesel

发明人： Reginald D. Robinson ,  Mary E. Robischon ,  Bernard Q. Li ,  Irfan Z. Ali ,  Steven R. Christenson ,  Keith A. Miesel

IPC分类号： A61M5/168 ,  A61M5/158 ,  A61M39/22

CPC分类号： A61M5/16827 ,  A61M5/14276 ,  A61M5/1684 ,  A61M39/223 ,  A61M2205/3523 ,  A61M2205/3569 ,  A61M2210/1003

摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the value to open and close the first fluid pathway and to open and close the second fluid pathway.

摘要翻译： 通常描述包括至少一个可控阀的治疗流体输送装置。 在一个示例中，可植入治疗流体递送系统包括构造成输送第一治疗流体的第一流体通路和构造成输送第二治疗流体的第二流体通路，第二流体通路与第一流体通路分离。 治疗流体递送系统包括连接到第一流体通路和第二流体通路的阀，以及配置成控制该值的致动以打开和关闭第一流体通路并打开和关闭第二流体通路的处理器。

公开(公告)号：US07801613B2

公开(公告)日：2010-09-21

申请号：US11796116

申请日：2007-04-26

申请人： Bernard Li ,  Reginald D. Robinson ,  John E. Kast

发明人： Bernard Li ,  Reginald D. Robinson ,  John E. Kast

IPC分类号： A61N1/375

CPC分类号： A61L27/06 ,  A61N1/375 ,  B22F3/225 ,  B22F2003/244 ,  B22F2998/10 ,  Y10T29/49002 ,  B22F3/1021 ,  B22F3/15 ,  B22F3/24 ,  B22F7/062

摘要： The housing of an implantable medical device is made of a titanium alloy that provides improved electrical performance, mechanical strength, and reduced MRI heating. The titanium alloy housing includes portions formed by metal injection molding and welded together. Wall thickness of at least a portion of one major face of the housing is reduced by chemical etching a metal injected molded housing portion.

摘要翻译： 可植入医疗器械的外壳由钛合金制成，提供改善的电气性能，机械强度和减少MRI加热。 钛合金壳体包括通过金属注射成型形成并焊接在一起的部分。 壳体的一个主面的至少一部分的壁厚通过化学蚀刻金属注入的模制外壳部分而减少。

公开(公告)号：US06743204B2

公开(公告)日：2004-06-01

申请号：US09834874

申请日：2001-04-13

申请人： Steven R. Christenson ,  Reginald D. Robinson ,  Kenneth T. Heruth ,  James M. Haase ,  Manfred Luedi

发明人： Steven R. Christenson ,  Reginald D. Robinson ,  Kenneth T. Heruth ,  James M. Haase ,  Manfred Luedi

IPC分类号： A61M100

CPC分类号： F04B43/1253 ,  A61M5/14232 ,  A61M5/14276 ,  A61M2205/0266 ,  F04B43/1276 ,  Y10T29/4924

摘要： An implantable drug infusion device includes a pump tube for holding a liquid to be pumped. A race is configured to support the pump tube. A roller assembly is configured to compress the tube against the race at one or more points along the path, and the roller assembly includes at least one roller and a hub. A drive assembly drives the roller assembly relative to the tube along the path so as to move the liquid through the tube. A retracting roller is operably connected to the hub and/or one or more adjacent rollers to permit retraction of the roller during installation of the pump tube between the roller and the race.

摘要翻译： 可植入药物输注装置包括用于保持要泵送的液体的泵管。 一个比赛被配置为支持泵管。 辊组件构造成在沿着路径的一个或多个点处压缩套管抵抗座圈，并且辊组件包括至少一个辊和轮毂。 驱动组件沿着路径相对于管驱动辊组件，以便使液体移动通过管。 回缩辊可操作地连接到轮毂和/或一个或多个相邻的辊子上，以允许在将泵管安装在辊子和座圈之间时缩回辊子。

公开(公告)号：US20080269829A1

公开(公告)日：2008-10-30

申请号：US11796116

申请日：2007-04-26

申请人： Bernard Li ,  Reginald D. Robinson ,  John E. Kast

发明人： Bernard Li ,  Reginald D. Robinson ,  John E. Kast

IPC分类号： A61N1/375 ,  A61N1/40 ,  B23P17/00

CPC分类号： A61L27/06 ,  A61N1/375 ,  B22F3/225 ,  B22F2003/244 ,  B22F2998/10 ,  Y10T29/49002 ,  B22F3/1021 ,  B22F3/15 ,  B22F3/24 ,  B22F7/062

摘要： The housing of an implantable medical device is made of a titanium alloy that provides improved electrical performance, mechanical strength, and reduced MRI heating. The titanium alloy housing includes portions formed by metal injection molding and welded together. Wall thickness of at least a portion of one major face of the housing is reduced by chemical etching a metal injected molded housing portion.

摘要翻译： 可植入医疗器械的外壳由钛合金制成，提供改善的电气性能，机械强度和减少MRI加热。 钛合金壳体包括通过金属注射成型形成并焊接在一起的部分。 壳体的一个主面的至少一部分的壁厚通过化学蚀刻金属注入的模制外壳部分而减少。

公开(公告)号：US07434312B2

公开(公告)日：2008-10-14

申请号：US10826088

申请日：2004-04-16

申请人： Steven R. Christenson ,  Reginald D. Robinson ,  Kenneth T. Heruth ,  James M. Haase ,  Mandred K. Luedi

发明人： Steven R. Christenson ,  Reginald D. Robinson ,  Kenneth T. Heruth ,  James M. Haase ,  Mandred K. Luedi

IPC分类号： B23P15/00 ,  A61M1/00

CPC分类号： F04B43/1253 ,  A61M5/14232 ,  A61M5/14276 ,  A61M2205/0266 ,  F04B43/1276 ,  Y10T29/4924

摘要： An implantable drug infusion device includes a pump tube for holding a liquid to be pumped. A race is configured to support the pump tube. A roller assembly is configured to compress the tube against the race at one or more points along the path, and the roller assembly includes at least one roller and a hub. A drive assembly drives the roller assembly relative to the tube along the path so as to move the liquid through the tube. A retracting roller is operably connected to the hub and/or one or more adjacent rollers to permit retraction of the roller during installation of the pump tube between the roller and the race.

摘要翻译： 可植入药物输注装置包括用于保持要泵送的液体的泵管。 一个比赛被配置为支持泵管。 辊组件构造成在沿着路径的一个或多个点处压缩套管抵抗座圈，并且辊组件包括至少一个辊和轮毂。 驱动组件沿着路径相对于管驱动辊组件，以便使液体移动通过管。 回缩辊可操作地连接到轮毂和/或一个或多个相邻的辊子上，以允许在将泵管安装在辊子和座圈之间时缩回辊子。