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1.发明申请公开(公告)号：US20110137372A1
公开(公告)日：2011-06-09
申请号：US12959890
申请日：2010-12-03
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0534
摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
摘要翻译： 提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。 该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。 如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧 效果。 例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。
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2.发明授权Methods and apparatus for using sensors with a deep brain stimulation system 有权使用具有深脑刺激系统的传感器的方法和装置公开(公告)号：US08670833B2
公开(公告)日：2014-03-11
申请号：US12959890
申请日：2010-12-03
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0534
摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
摘要翻译： 提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。 该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。 如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧 效果。 例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。
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公开(公告)号：US08731686B2
公开(公告)日：2014-05-20
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61N1/00
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译： 毛刺孔塞包括构造成围绕钻孔安装的塞子基座。 插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。 毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。 保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。 一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二 夹紧机构将医疗装置固定在其间。
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公开(公告)号：US20100145357A1
公开(公告)日：2010-06-10
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译： 毛刺孔塞包括构造成围绕钻孔安装的塞子基座。 插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。 毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。 保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。 一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二 夹紧机构将医疗装置固定在其间。
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公开(公告)号：US20090112327A1
公开(公告)日：2009-04-30
申请号：US12258382
申请日：2008-10-24
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base including a flange configured for being mounted around a burr hole, an aperture through which an elongated medical device may pass, and tabs configured for extending within the cranial burr hole to center the plug base relative to the cranial burr hole. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base to secure the medical device. A method may comprise locating the plug base within a burr hole, such that the tabs are disposed within the burr hole to center the plug base relative to the cranial burr hole, introducing the elongated medical device through the cranial burr hole and into the brain tissue of the patient, mounting the retainer within the aperture of the plug base, and actuating the retainer to secure the medical device.
摘要翻译： 一个钻孔塞包括一个插头基座，它包括一个凸缘，该凸缘被配置成安装在一个钻孔周围，一个细长的医疗设备可以通过的孔，以及在头部钻孔内延伸的突出部分，以使插头基座相对于头部 钻孔。 毛刺孔塞还包括保持器，其构造成安装在插头基座的孔内以固定医疗装置。 一种方法可以包括将插头基座定位在钻孔内，使得突出部设置在毛刺孔内，以使塞子基座相对于头颅毛孔中心，将细长的医疗装置通过头颅毛孔引入脑组织 将保持器安装在插头基座的孔内，并致动保持器以固定医疗装置。
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6.发明授权公开(公告)号：US08626297B2
公开(公告)日：2014-01-07
申请号：US12233810
申请日：2008-09-19
申请人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
发明人： Kristen Jaax , Rafael Carbunaru , Mun Pook Lui , Todd K. Whitehurst , Andrew DiGiore , Brett Daniel Schleicher , Gregory Baldwin , Michael A. Moffitt , Jeffery Van Funderburk , Jim Makous
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , H02J7/025 , H02J7/047 , H02J50/10
摘要： Apparatus and methods for charging an implanted medical device.
摘要翻译： 用于对植入的医疗装置充电的装置和方法。
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公开(公告)号：US20110054518A1
公开(公告)日：2011-03-03
申请号：US12549174
申请日：2009-08-27
CPC分类号： A61N1/0539 , A61B17/3415 , A61B90/14 , A61B2017/3419 , A61B2090/103 , A61M2039/025 , A61M2039/0276 , A61M2039/0282
摘要： A burr hole sealing device for preventing brain shift during a stimulation lead implantation procedure is provided. The device includes a suction cup ring and a self-sealing membrane positioned within the aperture of the ring. The sealing device is attached adjacent to a burr hole and over a dura layer that is exposed in the bottom of the burr hole. The stimulation lead is disposed through the burr hole, through the membrane, through the dura layer and into brain tissue. The membrane is configured to allow the lead to pass therethrough while maintaining a tight seal around the diameter of the lead, thereby hindering leakage of cerebrospinal fluid out of the cranial cavity and maintaining a substantially fixed intracranial pressure. In one embodiment, the sealing device includes a syringe for adding fluid to, or removing fluid from, the cranial cavity in response to a detected change in intracranial pressure.
摘要翻译： 提供了一种用于在刺激引线植入程序期间防止脑移位的钻孔密封装置。 该装置包括吸盘环和位于环的孔内的自密封膜。 密封装置邻近毛刺孔并暴露在钻孔底部的硬脑膜层上。 刺激引线通过毛刺孔穿过膜，穿过硬脑膜层并进入脑组织。 膜被配置为允许引线通过，同时保持围绕铅直径的紧密密封，从而阻止脑脊液从脑腔中泄漏并保持基本上固定的颅内压。 在一个实施例中，密封装置包括用于响应于检测到的颅内压变化而将流体添加到颅腔或从头颅腔移除流体的注射器。
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8.发明申请Optimal electrode contact polarity configurations for implantable stimulation systems 审中-公开可植入刺激系统的最佳电极接触极性配置公开(公告)号：US20070049988A1
公开(公告)日：2007-03-01
申请号：US11322788
申请日：2005-12-30
申请人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
发明人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： Systems for treating a patient with a medical condition include a lead having an array of electrode contacts each being programmable to have either a first polarity or a second polarity and a programming device configured to test a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied. Methods of using an implantable stimulator system include implanting a lead having an array of programmable electrode contacts disposed thereon in communication with a stimulation site, testing a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied, selecting an optimal electrode contact polarity configuration out of the multiplicity of different electrode contact polarity configurations, and applying the stimulation current via the optimal electrode contact polarity configuration to the stimulation site in accordance with one or more stimulation parameters.
摘要翻译： 用于治疗患有医疗状况的患者的系统包括具有每个可编程为具有第一极性或第二极性的电极接触阵列的引线和被配置为测试多个不同电极接触极性配置的编程设备，其中编程 一个或多个电极触点的极性是变化的。 使用可植入刺激器系统的方法包括植入具有与刺激部位连通的可编程电极触点阵列的引线，测试多个不同的电极接触极性配置，其中一个或多个电极触点的编程极性为 根据一个或多个刺激参数，通过不同电极接触极性配置的多重性选择最佳电极接触极性配置，并通过最佳电极接触极性配置将刺激电流施加到刺激部位。
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公开(公告)号：US20110019858A1
公开(公告)日：2011-01-27
申请号：US12506938
申请日：2009-07-21
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen Jaax , James Makous , Courtney Lane , Mark Pierre , Cliff Brainard , Charles Tilden Hagan, IV
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen Jaax , James Makous , Courtney Lane , Mark Pierre , Cliff Brainard , Charles Tilden Hagan, IV
IPC分类号： H04R11/04
CPC分类号： H04R1/028 , H04R1/14 , H04R2201/023
摘要： A communication system is provided for a patient featuring a cushion with an opening for receiving the face of the patient. The cushion includes a microphone for receiving audible signals from the patient and one or more speakers for delivering audible signals to the patient. The microphone and speaker(s) are integrated with the cushion to avoid interfering with the comfort of the patient. In one embodiment, the audible signals are delivered to and from the patient via a communication port. In another embodiment, the system includes a display device, so the patient may view parts of the patient's body on the device and then communicate with system operators through the microphone and speaker(s).
摘要翻译： 为患者提供通信系统，其特征在于具有用于接收患者面部的开口的缓冲垫。 垫子包括用于从患者接收听觉信号的麦克风和用于向患者传递可听信号的一个或多个扬声器。 麦克风和扬声器与衬垫集成，以避免干扰患者的舒适度。 在一个实施例中，可听信号经由通信端口传递给患者和从患者传送。 在另一个实施例中，系统包括显示装置，因此患者可以在装置上观察患者身体的部分，然后通过麦克风和扬声器与系统操作者通信。
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10.发明申请NEUROSTIMULATION SYSTEM AND METHOD FOR COMBINING CURRENT USING RECONFIGURABLE CURRENT SOURCES 审中-公开使用可重构电流源组合电流的神经网络系统和方法公开(公告)号：US20110125224A1
公开(公告)日：2011-05-26
申请号：US12952845
申请日：2010-11-23
申请人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36071
摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. One of the electrical sources is reconfigured from a second polarity to a first polarity. A first electrical current is generated with the one electrical source when configured in the first polarity. A second electrical current is generated with another one of the electrical sources. At least a portion of the first electrical current and at least a portion of the second electrical current is combined in one of an additive manner and a subtractive manner to produce a first combined electrical current. The first combined electrical current is conveyed to or from one or more of the electrodes.
摘要翻译： 提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。 电源中的一个从第二极性重新配置为第一极性。 当以第一极性配置时，利用一个电源产生第一电流。 与另一个电源产生第二电流。 第一电流的至少一部分和第二电流的至少一部分以加法方式和减法方式之一组合以产生第一组合电流。 第一组合电流被传送到一个或多个电极或从一个或多个电极传送。
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