公开(公告)号：US10020526B2

公开(公告)日：2018-07-10

申请号：US13611709

申请日：2012-09-12

Applicant: Timothy J. Fuller ,  Lijun Zou ,  Ion C. Halalay ,  James Mitchell ,  Mark W. Verbrugge

Inventor： Timothy J. Fuller ,  Lijun Zou ,  Ion C. Halalay ,  James Mitchell ,  Mark W. Verbrugge

IPC: H01M8/1069 ,  H01M2/14 ,  H01M8/1081 ,  C08K3/16

CPC classification number: H01M8/1079 ,  C08K3/16 ,  H01M2/145 ,  H01M8/1081 ,  Y02P70/56 ,  Y10T29/49108 ,  Y10T29/49826

Abstract: A method for forming a membrane includes a step of dissolving a lithium salt in a solution including an ionomer that includes protogenic groups to form a modified solution. A membrane is formed from the solution containing the lithium salt and the ionomer that includes protogenic groups. The membrane is dried and then contacted with water to form a plurality of pores therein.

公开(公告)号：US09901080B2

公开(公告)日：2018-02-27

申请号：US15067543

申请日：2016-03-11

Applicant: Buck Institute for Research on Aging ,  Erasmus University Medical Center Rotterdam ,  James Mitchell ,  Wendy Toussaint

Inventor： Judith Campisi ,  Marco Demaria ,  Remi-Martin Laberge ,  Francis Rodier ,  James Mitchell ,  Jan H. J. Hoeijmakers ,  Wendy Toussaint

IPC: A01K67/027 ,  A61K49/00 ,  C12N15/85

CPC classification number: A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0393 ,  A61K49/0008 ,  C12N15/8509 ,  C12N2015/859 ,  C12N2830/008

Abstract: This invention provides a transgenic mouse for studying the role of senescent cells on an age-related disorder or an age-sensitive trait. The transgene contains a p16 promoter sequence that controls expression of an enzyme so as to cause the enzyme to be expressed in senescent cells in the mouse. The enzyme converts a prodrug to a cytotoxic agent, so that treating the mouse with the prodrug results in the prodrug selectively killing the senescent cells. As a result, progression of an age-related disorder or an age-sensitive trait is delayed. Included is the 3MR mouse model, which also expresses bioluminescent and fluorescent markers under control of the p16 promoter so that senescent cells in the mice can be visualized.

公开(公告)号：US09631105B2

公开(公告)日：2017-04-25

申请号：US13568499

申请日：2012-08-07

Applicant: James Mitchell ,  Timothy J. Fuller

Inventor： James Mitchell ,  Timothy J. Fuller

IPC: H01M8/10 ,  B01J31/06 ,  C09D11/52 ,  H01M4/88 ,  H01M4/90 ,  H01M4/92 ,  H01M8/1007 ,  H01M8/1018

CPC classification number: C09D11/52 ,  H01M4/8807 ,  H01M4/8846 ,  H01M4/9075 ,  H01M4/925 ,  H01M8/1007 ,  H01M2008/1095 ,  Y02P70/56

Abstract: A metal electrode assembly for fuel cell applications includes a cathode catalyst layer, an anode catalyst layer, and an ion-conducting membrane disposed between the cathode catalyst layer and the anode catalyst layer. The cathode catalyst layer or the anode layer each independently including a catalyst composition and a first polymer wherein at least one of the cathode catalyst layer or the anode layer include a first polymer and polyphenylene sulfide-containing structures. A method for making a fuel cell catalyst layer is also provided.

公开(公告)号：US08853277B2

公开(公告)日：2014-10-07

申请号：US13512665

申请日：2010-11-30

Applicant: W. Marston Linehan ,  Tracey A. Rouault ,  James Mitchell ,  Murali K. Cherukuri

Inventor： W. Marston Linehan ,  Tracey A. Rouault ,  James Mitchell ,  Murali K. Cherukuri

IPC: A61K31/13 ,  A61K31/40 ,  A61K31/445 ,  A61K31/421

CPC classification number: A61K31/40 ,  A61K31/421 ,  A61K31/445

Abstract: The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2α.

Abstract translation: 本发明提供了治疗方法，其包括向被怀疑具有或具有与降低的VHL或升高的HIF-2α相关的病症的风险的受试者施用稳定的氮氧自由基。

公开(公告)号：US20140045093A1

公开(公告)日：2014-02-13

申请号：US13568494

申请日：2012-08-07

Applicant: James Mitchell ,  Lijun Zou ,  Timothy J. Fuller

Inventor： James Mitchell ,  Lijun Zou ,  Timothy J. Fuller

IPC: H01M8/10 ,  B29C45/14 ,  B82Y30/00

CPC classification number: D06M15/256 ,  D06M2101/30 ,  H01M8/1027 ,  H01M8/1048 ,  H01M2008/1095

Abstract: A metal electrode assembly includes a cathode catalyst layer, an anode catalyst layer, and an ion conducting membrane disposed between the cathode catalyst layer and the anode catalyst layer. The ion conducting layer includes a polyphenylene sulfide mat with a first polymer imbibed therein. The polyphenylene sulfide mat includes the polyphenylene sulfide-containing structures. A method for forming the ion conducting layer is also provided.

Abstract translation: 金属电极组件包括阴极催化剂层，阳极催化剂层和设置在阴极催化剂层和阳极催化剂层之间的离子导电膜。 离子传导层包括其中吸收有第一聚合物的聚苯硫醚垫。 聚苯硫醚垫包括含聚苯硫醚的结构。 还提供了一种用于形成离子传导层的方法。

公开(公告)号：US20130330653A1

公开(公告)日：2013-12-12

申请号：US13492387

申请日：2012-06-08

Applicant: James Mitchell ,  Lijun Zou ,  Timothy J. Fuller ,  Gerald W. Fly

Inventor： James Mitchell ,  Lijun Zou ,  Timothy J. Fuller ,  Gerald W. Fly

IPC: C08G75/14 ,  H01M8/04 ,  H01M8/10

CPC classification number: B01D71/66 ,  D01F6/765 ,  D04H1/4326 ,  H01M4/8814 ,  H01M4/8875 ,  H01M4/92

Abstract: A method for making hollow metal tubes includes a step combining a polyphenylene sulfide-containing resin with a water soluble carrier resin to form a resinous mixture. The resinous mixture is then extruded to form an extruded resinous mixture. The extruded resinous mixture includes polyphenylene sulfide-containing fibers within the carrier resin. The extruded resinous mixture is contacted (i.e., washed) with water to separate the polyphenylene sulfide-containing fibers from the carrier resin. The polyphenylene sulfide-containing fibers are then formed into a membrane.

Abstract translation: 制造中空金属管的方法包括将含有聚苯硫醚的树脂与水溶性载体树脂组合以形成树脂混合物的步骤。 然后将树脂混合物挤出以形成挤出的树脂混合物。 挤出的树脂混合物包括载体树脂内的含聚苯硫醚的纤维。 将挤出的树脂混合物与水接触（即洗涤）以从载体树脂中分离含聚苯硫醚的纤维。 然后将含聚苯硫醚的纤维形成膜。

公开(公告)号：US08381774B2

公开(公告)日：2013-02-26

申请号：US12884362

申请日：2010-09-17

Applicant: James Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

Inventor： James Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

IPC: B65B1/04 ,  B05D7/22

CPC classification number: A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

Abstract: Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

Abstract translation: 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US08285907B2

公开(公告)日：2012-10-09

申请号：US11009391

申请日：2004-12-10

Applicant: Christopher L. Chappell ,  James Mitchell

Inventor： Christopher L. Chappell ,  James Mitchell

IPC: G06F13/14

CPC classification number: G06F13/4027

Abstract: Methods and apparatus, including computer program products, implementing techniques for forming an Advanced Switching (AS) packet by applying AS path binding information to a packet received over a Peripheral Component Interconnect-Express (PCIe) fabric according to a downstream port identifier associated with the packet, and sending the AS packet to an AS fabric. Methods and apparatus, including computer program products, implementing techniques for processing an AS packet received over an AS fabric by comparing an AS payload of the AS packet with one or more memory spaces associated with port identifiers, determining whether the AS payload comprises a base packet to be transmitted to the PCIe fabric based on the comparison, and if so, removing an AS header from the AS packet to reveal the base packet.

Abstract translation: 方法和装置，包括计算机程序产品，通过将AS路径绑定信息应用于通过外围组件互连Express（PCIe）结构接收的分组，根据与所述外部组件互连 - 快速（PCIe）结构相关联的下游端口标识符来形成高级交换（AS）分组的实现技术 分组，并将AS数据包发送到AS架构。 方法和装置，包括计算机程序产品，通过将AS分组的AS有效载荷与与端口标识符相关联的一个或多个存储空间进行比较来确定AS有效载荷是否包括基本分组 基于比较将其发送到PCIe结构，如果是，则从AS分组中去除AS报头以显示基本分组。

公开(公告)号：US20120222843A1

公开(公告)日：2012-09-06

申请号：US13410647

申请日：2012-03-02

Applicant: James Mitchell

Inventor： James Mitchell

IPC: F28D15/00

CPC classification number: F04D19/002 ,  F04D19/007 ,  F04D25/166 ,  F24F1/38 ,  F24F1/56

Abstract: An architecture is presented that provides a an air conditioner booster device for improving the air flow across the condensing exchanger of an air conditioning unit thereby increasing the efficiency of the air conditioning unit. The air conditioner booster device is intended to increase the air flow created by a traditional air conditioner condenser fan. The air conditioner booster device is easily removably attachable to most conventional air conditioning units.

Abstract translation: 提出了一种架构，其提供了一种用于改善空调单元的冷凝交换器上的空气流的空调增压装置，从而提高空调单元的效率。 空调增压装置旨在增加由传统空调冷凝器风扇产生的气流。 空调增压装置容易地可拆卸地连接到大多数常规的空调单元。

公开(公告)号：US20120166699A1

公开(公告)日：2012-06-28

申请号：US12975944

申请日：2010-12-22

Applicant: Panakaj Kumar ,  James Mitchell

Inventor： Panakaj Kumar ,  James Mitchell

IPC: G06F13/14

CPC classification number: G06F13/385

Abstract: A method and apparatus to use Solid State Drives (SSD) in a high availability enterprise system is provided. Concurrent redundant paths are provided to the SSD to at least two storage controllers via a serial system bus using a non-storage bus protocol.

Abstract translation: 提供了一种在高可用性企业系统中使用固态硬盘（SSD）的方法和装置。 并行冗余路径通过使用非存储总线协议的串行系统总线提供给SSD至少两个存储控制器。