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公开(公告)号：US20170355731A1
公开(公告)日：2017-12-14
申请号：US15524197
申请日：2015-11-05
申请人： Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno
发明人： Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno
CPC分类号： C07K7/64 , C07K16/22 , C07K16/30 , C07K2319/30
摘要： The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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公开(公告)号：US09988420B2
公开(公告)日：2018-06-05
申请号：US15104727
申请日：2014-12-17
申请人： Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang , Yunho Jin
发明人： Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang , Yunho Jin
CPC分类号： C07K5/0205 , A61K47/6817 , A61K47/6851 , C07K7/02 , C07K16/32
摘要： Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US20150105390A1
公开(公告)日：2015-04-16
申请号：US14574063
申请日：2014-12-17
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/506 , A61K45/06 , A61K31/5377 , C07D239/48 , C07D401/14 , C07D401/12
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US08957081B2
公开(公告)日：2015-02-17
申请号：US13610422
申请日：2012-09-11
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje, III , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/519 , A61K31/52 , A61K31/517 , C07D239/02 , C07D239/42 , C07D403/12 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US20110257154A1
公开(公告)日：2011-10-20
申请号：US13172357
申请日：2011-06-29
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/397 , A61K31/506 , C07D239/48 , A61K31/505 , C07D413/14 , A61K31/5377 , C07D413/12 , C07D403/12 , A61K31/496 , C07D487/04 , A61K31/519 , A61K31/52 , A61P31/00 , A61P35/00 , C12N5/09 , C07D401/14
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号：US20110053897A1
公开(公告)日：2011-03-03
申请号：US12843771
申请日：2010-07-26
申请人： Jianwei CHE , Bei Chen , Qiang Ding , Xueshi Hao , Xiaohui He , Songchun Jiang , Qihui Jin , Yunho Jin , Hong Liu , Yahua Liu , Barun Okram , Tetsuo Uno , Xu Wu , Kunyong Yang , Xuefeng Zhu
发明人： Jianwei CHE , Bei Chen , Qiang Ding , Xueshi Hao , Xiaohui He , Songchun Jiang , Qihui Jin , Yunho Jin , Hong Liu , Yahua Liu , Barun Okram , Tetsuo Uno , Xu Wu , Kunyong Yang , Xuefeng Zhu
IPC分类号： A61K31/635 , C07D471/04 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/444 , A61P11/06 , A61P19/02 , A61P35/00 , A61P7/06 , A61P25/00
CPC分类号： C07D471/04 , A61K31/4375
摘要： Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
摘要翻译： 本文提供了区域新颖的化合物类，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。
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公开(公告)号：US20110190259A1
公开(公告)日：2011-08-04
申请号：US13048636
申请日：2011-03-15
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/506 , C07D401/14 , C12N9/99 , C07D239/24 , C07D413/14 , A61K31/5377 , C07D403/02 , A61P25/00 , A61P37/06
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
摘要翻译： 本发明提供新颖的嘧啶和吡啶衍生物及其药物组合物，以及使用这些化合物的方法。 例如，本发明的嘧啶和吡啶衍生物可用于治疗，改善或预防响应于间变性淋巴瘤激酶（ALK）活性，粘着斑激酶（FAK），ζ-链相关蛋白激酶70 （ZAP-70），胰岛素样生长因子（IGF-1R）或其组合。
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公开(公告)号：US20110003798A1
公开(公告)日：2011-01-06
申请号：US12865339
申请日：2009-01-27
申请人： Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
发明人： Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
IPC分类号： A61K31/5415 , C07D471/04 , C07D498/04 , A61K31/4375 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/541 , A61K31/497 , A61K31/538 , A61K31/5383 , A61K31/501 , A61P11/06 , A61P11/08 , A61P11/00 , A61P17/00 , A61P17/06 , A61P11/02 , A61P29/00 , A61P25/00 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号： C07D471/04
摘要： The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof.
摘要翻译： 本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗的方法o预防与异常或失调的激酶活性相关的疾病或病症，特别是Syk，ZAP70，KDR，FMS，FLT *，c-Kit，RET，TrkA，TrkB，TrkC- GR-1R，Alk，c-FMS或其组合。
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公开(公告)号：US20130005748A1
公开(公告)日：2013-01-03
申请号：US13610422
申请日：2012-09-11
申请人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
发明人： Pierre-Yves Michellys , Wei Pei , Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Tetsuo Uno , Yunho Jin , Tao Jiang
IPC分类号： A61K31/519 , A61P31/00 , A61P35/00 , A61P37/06 , A61K31/52 , A61K31/517
CPC分类号： A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D239/48 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D451/02 , C07D453/02 , C07D471/04 , C07D473/16 , C07D487/04 , C07D487/08
摘要： The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof.
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公开(公告)号：US08546370B2
公开(公告)日：2013-10-01
申请号：US12865339
申请日：2009-01-27
申请人： Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
发明人： Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
IPC分类号： A61K31/33
CPC分类号： C07D471/04
摘要： The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.
摘要翻译： 本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调激酶活性相关的疾病或病症的方法，特别是Syk，ZAP70，KDR，FMS，FLT3，c-Kit，RET，TrkA，TrkB，TrkC-GR -1R，Alk，c-FMS或其组合。
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