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公开(公告)号：US08110366B2
公开(公告)日：2012-02-07
申请号：US11988418
申请日：2006-07-07
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sarl Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sarl Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US20090148839A1
公开(公告)日：2009-06-11
申请号：US11988418
申请日：2006-07-07
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US09382512B2
公开(公告)日：2016-07-05
申请号：US13352269
申请日：2012-01-17
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
IPC分类号： C12N5/00 , G01N33/50 , G01N33/569 , C12N5/0775
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US20120190058A1
公开(公告)日：2012-07-26
申请号：US13352269
申请日：2012-01-17
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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5.发明申请NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开新型碳水化合物人体细胞组成及其分析及其改良方法公开(公告)号：US20100145032A1
公开(公告)日：2010-06-10
申请号：US12523628
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
IPC分类号： C12Q1/02 , C12N5/074 , C12P21/00 , C07K14/435
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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6.发明授权Carbohydrate profile compositions from human cells and methods for analysis and modification thereof 有权来自人细胞的碳水化合物曲线组合物及其分析和修饰方法公开(公告)号：US08691774B2
公开(公告)日：2014-04-08
申请号：US11988564
申请日：2006-07-11
申请人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
发明人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
IPC分类号： G01N33/577 , G01N33/574
CPC分类号： C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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7.发明申请Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof 有权来自人类细胞的新型碳水化合物组成及其分析和修饰方法公开(公告)号：US20100055710A1
公开(公告)日：2010-03-04
申请号：US11988564
申请日：2006-07-11
申请人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
发明人： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
CPC分类号： C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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8.发明申请NOVEL CARBOHYDRATE FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开来自人类细胞的新型碳水化合物及其分析和改性方法公开(公告)号：US20100028913A1
公开(公告)日：2010-02-04
申请号：US12523586
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
IPC分类号： G01N33/569 , G01N33/53 , G01N33/577
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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9.发明申请Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof 审中-公开来自人类细胞的新型碳水化合物组成及其分析和修饰方法公开(公告)号：US20090162938A1
公开(公告)日：2009-06-25
申请号：US12084626
申请日：2006-11-08
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola
CPC分类号： G01N33/5073 , G01N2400/12 , G01N2400/38
摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
摘要翻译： 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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公开(公告)号：US20100047827A1
公开(公告)日：2010-02-25
申请号：US12522858
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Ulla Impola , Olli Aitio , Leena Valmu , Suvi Natunen , Hanna Salo
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Ulla Impola , Olli Aitio , Leena Valmu , Suvi Natunen , Hanna Salo
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/44 , G01N33/56966 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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