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1.发明申请Niacin receptor agonists, compositions containing such compounds and methods of treatment 审中-公开烟酸受体激动剂，含有这些化合物的组合物和治疗方法公开(公告)号：US20090054423A1
公开(公告)日：2009-02-26
申请号：US11918270
申请日：2006-04-07
申请人： Jason E. Imbriglio , Steven L. Colletti , James R. Tata , Rui Liang , Subharekha Raghavan , Darby R. Schmidt , Abigail L. Smenton , Sook Yee Chan
发明人： Jason E. Imbriglio , Steven L. Colletti , James R. Tata , Rui Liang , Subharekha Raghavan , Darby R. Schmidt , Abigail L. Smenton , Sook Yee Chan
IPC分类号： A61K31/538 , C07D257/04 , A61K31/41 , C07D231/54 , A61K31/416 , C07D261/06 , A61K31/42 , C07D403/02 , A61P9/10 , A61P3/10 , A61K31/506 , C07D401/02 , A61K31/4439 , C07D277/20 , A61K31/426 , A61K31/497 , A61K31/437
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗血脂异常的式I化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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2.发明授权Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof 失效四唑衍生物及其代谢相关病症的治疗方法公开(公告)号：US08637555B2
公开(公告)日：2014-01-28
申请号：US10535345
申请日：2004-10-29
申请人： Graeme Semple , Thomas Schrader , Philip J. Skinner , Steven L. Colletti , Tawfik Gharbaoui , Jason E. Imbriglio , Jae-Kyu Jung , Rui Liang , Subharekha Raghavan , Darby Schmidt , James R. Tata
发明人： Graeme Semple , Thomas Schrader , Philip J. Skinner , Steven L. Colletti , Tawfik Gharbaoui , Jason E. Imbriglio , Jae-Kyu Jung , Rui Liang , Subharekha Raghavan , Darby Schmidt , James R. Tata
IPC分类号： A61K31/407 , C07D231/54
CPC分类号： C07D491/04 , C07D403/04 , C07D495/04
摘要： The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
摘要翻译： 本发明涉及式（I）的某些四唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。
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3.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20090042926A1
公开(公告)日：2009-02-12
申请号：US12086938
申请日：2006-12-20
申请人： Jason Imbriglio , Steven L. Colletti , James R. Tata , Richard T. Beresis , Daria Marley , Subharekha Raghavan , Darby Rye Schmidt , Ashley Rouse Lins , Abigail L. Smenton , Weichun Chen , Hong Shen , Fa-Xiang Ding , Rena Bodner
发明人： Jason Imbriglio , Steven L. Colletti , James R. Tata , Richard T. Beresis , Daria Marley , Subharekha Raghavan , Darby Rye Schmidt , Ashley Rouse Lins , Abigail L. Smenton , Weichun Chen , Hong Shen , Fa-Xiang Ding , Rena Bodner
IPC分类号： A61K31/4439 , C07C229/34 , C07D277/22 , C07D271/06 , C07D413/04 , A61K31/437 , A61P9/10 , A61P3/10 , C07D471/04 , A61K31/196 , A61K31/426 , A61K31/4245
CPC分类号： C07D277/28 , C07C237/20 , C07D231/12 , C07D263/32 , C07D271/06 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式（I）化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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4.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 有权烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20100144778A1
公开(公告)日：2010-06-10
申请号：US11922629
申请日：2006-06-26
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/437 , C07C233/02 , C07C229/38 , C07D413/04 , C07D513/04 , C07D471/14 , A61K31/165 , A61K31/192 , A61K31/4439 , A61K31/4245 , A61P9/10
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式（I）化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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5.发明授权Niacin receptor agonists, compositions containing such compounds and methods of treatment 有权烟酸受体激动剂，含有这些化合物的组合物和治疗方法公开(公告)号：US08168649B2
公开(公告)日：2012-05-01
申请号：US11922629
申请日：2006-06-26
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/44 , A01N43/40 , A61K31/19 , A61K31/165
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式（I）化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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6.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20120178750A1
公开(公告)日：2012-07-12
申请号：US13423618
申请日：2012-03-19
申请人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
发明人： Subharekha Raghavan , Steven L. Colletti , Fa-Xiang Ding , Hong Shen , James R. Tata , Ashley Rouse Lins , Abigail Lee Smenton , Weichun Chen , Darby Rye Schmidt , George Scott Tria
IPC分类号： A61K31/4439 , A61K31/423 , A61K31/429 , A61K31/41 , A61K31/426 , A61K31/427 , A61K31/403 , A61K31/4375 , A61K31/437 , A61K31/538 , A61K31/4196 , A61P9/10 , A61P3/06 , A61P3/10 , A61P3/00 , A61K31/196
CPC分类号： C07D261/20 , C07C233/52 , C07C233/55 , C07C235/36 , C07C237/20 , C07C2601/10 , C07C2601/16 , C07D231/12 , C07D249/06 , C07D249/08 , C07D257/04 , C07D271/06 , C07D277/30 , C07D307/79 , C07D309/14 , C07D309/28 , C07D401/04 , C07D413/04 , C07D417/04 , C07D513/04
摘要： The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式I化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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7.发明申请Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment 审中-公开烟酸受体激动剂，包含这些化合物的组合物和治疗方法公开(公告)号：US20090170891A1
公开(公告)日：2009-07-02
申请号：US12226050
申请日：2007-04-06
申请人： Steven L. Colletti , James R. Tata , Weichun Chen , Richard T. Beresis , Fa-Xiang Ding , Darby Rye Schmidt , Hong Shen , Subharekha Raghavan
发明人： Steven L. Colletti , James R. Tata , Weichun Chen , Richard T. Beresis , Fa-Xiang Ding , Darby Rye Schmidt , Hong Shen , Subharekha Raghavan
IPC分类号： A61K31/4375 , C07D333/36 , A61K31/381 , C07D413/04 , A61K31/444 , C07D333/38 , A61P3/10
CPC分类号： C07D333/38 , C07D277/56 , C07D333/40 , C07D413/14
摘要： The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
摘要翻译： 本发明包括可用于治疗动脉粥样硬化，血脂异常等的式I化合物及其药学上可接受的盐和水合物。 还包括药物组合物和使用方法。
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8.发明申请Niacin Receptor Agonists, compositions Containing Such Compounds and Methods of Treatment 审中-公开烟酸受体激动剂，含有这些化合物的组合物和治疗方法公开(公告)号：US20110028462A1
公开(公告)日：2011-02-03
申请号：US11992069
申请日：2006-09-15
IPC分类号： A61K31/538 , A61P9/10 , A61P3/10 , A61P3/06 , A61K31/381 , A61K31/428 , A61K31/4725 , A61K31/4709 , A61K31/415 , A61K31/403 , A61K31/437
CPC分类号： A61K31/433 , C07D209/18 , C07D209/58 , C07D231/04 , C07D265/30 , C07D277/06 , C07D333/20 , C07D409/04 , C07D417/04 , C07D487/14
摘要： A method of treating atherosclerosis and related conditions using compounds of formula I: as well as pharmaceutically acceptable salts and solvates is disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels.
摘要翻译： 公开了使用式I化合物治疗动脉粥样硬化和相关病症的方法：以及药学上可接受的盐和溶剂合物。 该化合物可用于治疗血脂异常，特别是降低血清LDL，VLDL和甘油三酸酯，并提高HDL水平。
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9.发明申请公开(公告)号：US20090062269A1
公开(公告)日：2009-03-05
申请号：US12223492
申请日：2007-02-02
IPC分类号： A61K31/195 , C07D277/30 , C07C229/46 , C07D211/78 , C07D213/61 , C07D213/56 , A61K31/444 , A61K31/4418 , A61K31/381 , A61K31/538 , A61K31/4375 , A61K31/404 , A61K31/437 , A61P3/10 , A61K31/426 , A61K31/4439 , C07D413/14 , C07D403/04 , C07D401/04 , C07D333/24 , A61P3/00
CPC分类号： C07C235/34 , C07C233/52 , C07C2601/16 , C07D211/78 , C07D213/55 , C07D213/61 , C07D277/30 , C07D333/24 , C07D401/04 , C07D413/04
摘要： The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
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10.发明申请Niacin receptor agonists, compositions containing such compounds and methods of treatment 审中-公开烟酸受体激动剂，含有这些化合物的组合物和治疗方法公开(公告)号：US20090258862A1
公开(公告)日：2009-10-15
申请号：US11991188
申请日：2006-08-25
IPC分类号： A61K31/55 , C07D403/04 , C07D487/08 , C07D401/04 , A61K31/495
CPC分类号： C07D403/04 , C07D207/09 , C07D211/40 , C07D241/04 , C07D413/04 , C07D491/10
摘要： Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了式（I）的化合物以及药学上可接受的盐和溶剂合物。 该化合物可用于治疗血脂异常，特别是降低血清LDL，VLDL和甘油三酸酯，并提高HDL水平。 还包括药物组合物和治疗方法。
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