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    IMMUNOGENIC PEPTIDES FOR THE TREATMENT OF PROSTATE AND BREAST CANCER
    1.
    发明申请
    IMMUNOGENIC PEPTIDES FOR THE TREATMENT OF PROSTATE AND BREAST CANCER 有权
    用于治疗前列腺癌和乳腺癌的免疫抑制剂

    公开(公告)号：US20090208518A1

    公开(公告)日：2009-08-20

    申请号：US12430837

    申请日：2009-04-27

    申请人： Jay A. Berzofsky ,  SangKon Oh ,  Ira Pastan

    发明人： Jay A. Berzofsky ,  SangKon Oh ,  Ira Pastan

    IPC分类号： A61K39/00 ,  C07K7/00 ,  C12N15/11 ,  C12N15/79 ,  C12N5/10 ,  A61P35/00 ,  A61K31/711 ,  C12N5/00 ,  G01N33/566 ,  A61K38/08

    CPC分类号： C07K14/4748 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/57

    摘要： Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed.

    摘要翻译： 本文公开了免疫原性T细胞受体γ替代阅读框蛋白（TARP）多肽。 这些免疫原性TARP多肽包括SEQ ID NO：9所示的氨基酸序列的9个连续氨基酸，并且不包含SEQ ID NO：1的氨基酸1-26或氨基酸38-58。几个具体的，非限制性的 这些多肽的实例如SEQ ID NO：3-7所示。 还公开了编码这些多肽的核酸和用这些核酸转染的宿主细胞。 还公开了使用这些多肽的方法和编码这些多肽的多核苷酸用于治疗乳腺癌和前列腺癌。

    Immunogenic peptides for the treatment of prostate and breast cancer
    2.
    发明授权
    Immunogenic peptides for the treatment of prostate and breast cancer 有权
    用于治疗前列腺癌和乳腺癌的免疫原性肽

    公开(公告)号：US08043623B2

    公开(公告)日：2011-10-25

    申请号：US12430837

    申请日：2009-04-27

    申请人： Jay A. Berzofsky ,  SangKon Oh ,  Ira Pastan

    发明人： Jay A. Berzofsky ,  SangKon Oh ,  Ira Pastan

    IPC分类号： C07K5/00

    CPC分类号： C07K14/4748 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/57

    摘要： Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed.

    摘要翻译： 本文公开了免疫原性T细胞受体γ替代阅读框蛋白（TARP）多肽。 这些免疫原性TARP多肽包括SEQ ID NO：9所示的氨基酸序列的9个连续氨基酸，并且不包含SEQ ID NO：1的氨基酸1-26或氨基酸38-58。几个具体的，非限制性的 这些多肽的实例如SEQ ID NO：3-7所示。 还公开了编码这些多肽的核酸和用这些核酸转染的宿主细胞。 还公开了使用这些多肽的方法和编码这些多肽的多核苷酸用于治疗乳腺癌和前列腺癌。

    Immunogenic peptides for the treatment of prostate and breast cancer
    3.
    发明授权
    Immunogenic peptides for the treatment of prostate and breast cancer 有权
    用于治疗前列腺癌和乳腺癌的免疫原性肽

    公开(公告)号：US07541035B2

    公开(公告)日：2009-06-02

    申请号：US10559329

    申请日：2004-06-02

    申请人： Jay A. Berzofsky ,  SangKon Oh ,  Ira Pastan

    发明人： Jay A. Berzofsky ,  SangKon Oh ,  Ira Pastan

    IPC分类号： C07K5/00

    CPC分类号： C07K14/4748 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/57

    摘要： Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed.

    摘要翻译： 本文公开了免疫原性T细胞受体γ替代阅读框蛋白（TARP）多肽。 这些免疫原性TARP多肽包括SEQ ID NO：9所示的氨基酸序列的9个连续氨基酸，并且不包含SEQ ID NO：1的氨基酸1-26或氨基酸38-58。几个具体的，非限制性的 这些多肽的实例如SEQ ID NO：3-7所示。 还公开了编码这些多肽的核酸和用这些核酸转染的宿主细胞。 还公开了使用这些多肽的方法和编码这些多肽的多核苷酸用于治疗乳腺癌和前列腺癌。

    Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein
    6.
    发明授权
    Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein 失效
    将抗原用炭疽毒素融合蛋白靶向MHC I类加工途径

    公开(公告)号：US06592872B1

    公开(公告)日：2003-07-15

    申请号：US08937276

    申请日：1997-09-15

    申请人： Kurt Klimpel ,  Theresa J. Goletz ,  Naveen Arora ,  Stephen H. Leppla ,  Jay A. Berzofsky

    发明人： Kurt Klimpel ,  Theresa J. Goletz ,  Naveen Arora ,  Stephen H. Leppla ,  Jay A. Berzofsky

    IPC分类号： A61K3907

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K14/32 ,  C07K2319/00 ,  C12N2740/16122 ,  Y02A50/412 ,  Y02A50/423 ,  Y10S514/885 ,  Y10S530/806 ,  Y10S530/825

    摘要： The present invention provides a vaccine for inducing an immune response in mammal to a specific antigen, where the vaccine comprises a unit dose of a binary, cytotoxic T lymphocyte vaccine comprising an anthrax protective antigen and a full length protein antigen bound to a nontoxic anthrax protective antigen binding protein comprising at least about the first 250 amino acid residues of the lethal factor of Bacillus anthracis and less than all of the amino acid residues of the lethal factor. The present invention also provides a method of immunizing a mammal against an antigen using the vaccine, and a method of inducing antigen-presenting mammalian cells to present specific antigens via the MHC class I processing pathway.

    摘要翻译： 本发明提供了用于在哺乳动物中诱导特异性抗原的免疫应答的疫苗，其中疫苗包含单位剂量的二元细胞毒性T淋巴细胞疫苗，其包含炭疽保护性抗原和与无毒性炭疽保护性结合的全长蛋白质抗原 抗原结合蛋白，其包含至少约大约碳芽孢杆菌致死因子的250个氨基酸残基并且小于致死因子的全部氨基酸残基。 本发明还提供了使用该疫苗免疫哺乳动物抗原的方法，以及通过MHC I类加工途径诱导抗原呈递哺乳动物细胞呈递特异性抗原的方法。

    Method of producing immune response
    7.
    发明授权
    Method of producing immune response 失效
    产生免疫反应的方法

    公开(公告)号：US5283323A

    公开(公告)日：1994-02-01

    申请号：US715712

    申请日：1991-06-18

    申请人： Jay A. Berzofsky ,  Hajime Kawamura

    发明人： Jay A. Berzofsky ,  Hajime Kawamura

    IPC分类号： A61K39/00 ,  A61K47/48 ,  C07K14/47 ,  C07K14/805 ,  C07K16/42 ,  C07K13/00

    CPC分类号： C07K16/4283 ,  A61K47/4833 ,  C07K14/47 ,  C07K14/805 ,  A61K39/00

    摘要： The present invention discloses a process for enhancing antibody response to an antigen. A novel step in the process is the preparation of a conjugate of the antigen with an anti-immunoglobulin. The conjugate thus prepared is then administered to a host for in vivo effect or presented to T and B cells in a suitable culture system for in vitro response. The present invention by increasing immunogenicity makes it possible to produce antibodies against very low doses of antigens and otherwise weak or insufficient antigens or synthetic vaccines.

    摘要翻译： 本发明公开了一种增强对抗原的抗体应答的方法。 该方法的新颖步骤是制备抗原与抗免疫球蛋白的缀合物。 然后将如此制备的缀合物施用于宿主用于体内效应，或者在合适的培养系统中呈递给T细胞和B细胞用于体外应答。 本发明通过增加免疫原性使得可以产生针对非常低剂量的抗原的抗体，否则产生弱或不足的抗原或合成疫苗。

    Immunogenic Peptides of Xage-1
    9.
    发明申请
    Immunogenic Peptides of Xage-1 审中-公开
    Xage-1免疫原性肽

    公开(公告)号：US20130171178A1

    公开(公告)日：2013-07-04

    申请号：US10582703

    申请日：2004-12-13

    申请人： Jay A. Berzofsky ,  Ira H. Pastan ,  Masaki Terabe

    发明人： Jay A. Berzofsky ,  Ira H. Pastan ,  Masaki Terabe

    IPC分类号： C07K7/06 ,  A61K39/00 ,  A61K45/06 ,  C07K7/08 ,  C12P21/06 ,  C07H21/04 ,  C07K14/82

    CPC分类号： C07K7/06 ,  A61K39/0011 ,  A61K45/06 ,  C07K14/4748

    摘要： XAGE-1 is a gene expressed in a number of important human cancers, including prostate cancer, lung cancer, breast cancer, ovarian cancer, glioblastoma, pancreatic cancer, and melanoma. It has now been discovered that peptides of fifty or fewer amino acids comprising the sequence X1X2X3PSAPSPX4 (SEQ ID NO:5), where X1 is any amino acid and is preferably G or Y; X2 is selected from the group consisting of L, M, A, I, V, and T, with L and M being preferred; X3 is a hydrophobic residue, M or A; and X4 is V, M, L, A, I, or T, and is preferably V, bind to the HLA-A2 MHC class I molecule, and can be used to raise immune responses to XAGE-1-expressing cancers. In some embodiments, the P at position 7, the S at position 8, or the P at position 9, can be omitted to create a 9 amino acid peptide. The invention provides immunogenic peptides, nucleic acids encoding them, vectors comprising the nucleic acids, uses of the peptides and nucleic acids for manufacture of medicaments, methods of using the peptides and nucleic acids, and compositions of the peptides or nucleic acids in pharmaceutically acceptable carriers.

    摘要翻译： XAGE-1是在许多重要的人类癌症中表达的基因，包括前列腺癌，肺癌，乳腺癌，卵巢癌，胶质母细胞瘤，胰腺癌和黑素瘤。 现在已经发现包含序列X1X2X3PSAPSPX4（SEQ ID NO：5）的五十个或更少的氨基酸的肽，其中X 1是任何氨基酸并且优选是G或Y; X2选自L，M，A，I，V和T，其中L和M是优选的; X3是疏水残基M或A; 并且X4是V，M，L，A，I或T，并且优选为V，结合HLA-A2 MHC I类分子，并且可用于引起对表达XAGE-1的癌症的免疫应答。 在一些实施方案中，可以省略位置7处的P，位置8处的S或位置9处的P，以产生9个氨基酸的肽。 本发明提供免疫原性肽，编码它们的核酸，包含核酸的载体，肽和核酸用于制备药物的用途，使用肽和核酸的方法，以及肽或核酸在药学上可接受的载体中的组合物 。