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公开(公告)号：US07173043B2
公开(公告)日：2007-02-06
申请号：US11178164
申请日：2005-07-08
IPC分类号： A61K31/4453 , A61K31/428 , A61K31/381 , C07D417/10 , C07D275/04 , C07D333/58
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US06953806B2
公开(公告)日：2005-10-11
申请号：US10315770
申请日：2002-12-10
申请人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand
发明人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand
IPC分类号： C07D295/12 , A61K31/18 , A61K31/223 , A61K31/27 , A61K31/325 , A61K31/397 , A61K31/40 , A61K31/4164 , A61K31/445 , A61K31/4453 , A61K31/505 , A61K31/5375 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , A61P43/00 , C07B61/00 , C07C269/04 , C07C269/06 , C07C271/46 , C07C271/48 , C07C271/52 , C07C291/04 , C07C303/40 , C07C311/17 , C07C311/18 , C07D203/12 , C07D205/04 , C07D207/08 , C07D211/46 , C07D233/52 , C07D233/60 , C07D239/42 , C07D295/084 , C07D295/088 , C07D295/10 , C07D295/135 , C07D521/00 , C07D211/06
CPC分类号： C07D207/08 , C07C271/52 , C07C311/17 , C07C311/18 , C07C2601/14 , C07D205/04 , C07D211/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/084 , C07D295/088 , C07D295/135
摘要： The present invention provides compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, U, V, W, m, n and p are as indicated in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia and hyperlipemia.
摘要翻译： 本发明提供式（I）的化合物，其中A 1，A 2，S 3，S 4， ，A 5，A 6，A 7，A 8，A 9， A，U，V，W，m，n和p如说明书中所示，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症和高脂血症相关的疾病。
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公开(公告)号：US20070099985A1
公开(公告)日：2007-05-03
申请号：US11634573
申请日：2006-12-06
IPC分类号： A61K31/381 , C07D333/72
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及异离子OSC抑制剂。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US06858651B2
公开(公告)日：2005-02-22
申请号：US09925188
申请日：2001-08-09
申请人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
IPC分类号： C07D295/08 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/223 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C269/04 , C07C271/24 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C303/38 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07D205/04 , C07D207/12 , C07D209/42 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/70 , C07D213/81 , C07D215/36 , C07D233/84 , C07D261/10 , C07D295/092 , C07D295/135 , C07D295/14 , C07D307/38 , C07D309/12 , C07D317/58 , C07D333/24 , C07D333/34 , C07D333/40 , A61K31/14 , C07C43/20
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US07449483B2
公开(公告)日：2008-11-11
申请号：US11634573
申请日：2006-12-06
IPC分类号： A61K31/445 , A61K31/38 , A61K31/40 , C07D409/06 , C07D333/58 , C07D333/64 , C07D411/06 , C07D205/02 , C07D205/10
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及异离子OSC抑制剂。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US07335687B2
公开(公告)日：2008-02-26
申请号：US11014374
申请日：2004-12-15
申请人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
IPC分类号： A61K31/14 , C07C205/00
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US20050176766A1
公开(公告)日：2005-08-11
申请号：US11014374
申请日：2004-12-15
申请人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Denise Blum , Alexander Chucholowski , Henrietta Dehmlow , Hans-Peter Maerki , Olivier Morand , Rene Trussardi , Elisabeth von der Mark , Sabine Wallbaum , Thomas Weller
IPC分类号： C07D295/08 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/223 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/351 , A61K31/36 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C269/04 , C07C271/24 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C303/38 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07D205/04 , C07D207/12 , C07D209/42 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/70 , C07D213/81 , C07D215/36 , C07D233/84 , C07D261/10 , C07D295/092 , C07D295/135 , C07D295/14 , C07D307/38 , C07D309/12 , C07D317/58 , C07D333/24 , C07D333/34 , C07D333/40 , C07D211/26
CPC分类号： C07D295/088 , C07C233/23 , C07C233/74 , C07C235/54 , C07C235/84 , C07C255/57 , C07C271/52 , C07C271/56 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C291/04 , C07C307/08 , C07C307/10 , C07C311/07 , C07C311/13 , C07C311/20 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/22 , C07C2601/02 , C07C2601/14 , C07D295/135
摘要： The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的氨基环己醇衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US07442791B2
公开(公告)日：2008-10-28
申请号：US10942154
申请日：2004-09-16
申请人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand , Narendra Panday
发明人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand , Narendra Panday
IPC分类号： C07D243/08 , A01N43/00 , A61K31/33
CPC分类号： C07D239/26 , C07C271/56 , C07C311/20 , C07C2601/14 , C07D239/30 , C07D295/185 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3，R 4， R 5，U，V，W，k和m如说明书和权利要求书及其药学上可接受的盐和/或其药学上可接受的酯所定义。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶相关的疾病，例如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染，胆结石，肿瘤和/或过度增殖性疾病， 以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US07012077B2
公开(公告)日：2006-03-14
申请号：US10310559
申请日：2002-12-05
IPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61P3/00 , A61P3/06
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D237/22 , C07D239/42 , C07D401/04 , C07D409/04
摘要： The present invention relates to compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, U, V, m, n and o are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the 2,3-oxidosqualene-lanosterol cyclase biosynthetic pathway such as hypercholesterolemia and hyperlipemia.
摘要翻译： 本发明涉及式（I）的化合物，其中A 1，A 2，A 3，A 4， 其中，A 5，A 6，U，V，m，n和o如说明书中所定义，及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶生物合成途径相关的疾病，例如高胆固醇血症和高脂血症。
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公开(公告)号：US20050272774A1
公开(公告)日：2005-12-08
申请号：US11176901
申请日：2005-07-07
申请人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand
发明人： Jean Ackermann , Johannes Aebi , Henrietta Dehmlow , Georges Hirth , Hans-Peter Maerki , Olivier Morand
IPC分类号： C07D295/12 , A61K31/18 , A61K31/223 , A61K31/27 , A61K31/325 , A61K31/397 , A61K31/40 , A61K31/4164 , A61K31/445 , A61K31/4453 , A61K31/505 , A61K31/5375 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , A61P43/00 , C07B61/00 , C07C269/04 , C07C269/06 , C07C271/46 , C07C271/48 , C07C271/52 , C07C291/04 , C07C303/40 , C07C311/17 , C07C311/18 , C07D203/12 , C07D205/04 , C07D207/08 , C07D211/46 , C07D233/52 , C07D233/60 , C07D239/42 , C07D295/084 , C07D295/088 , C07D295/10 , C07D295/135 , C07D521/00 , C07D211/26
CPC分类号： C07D207/08 , C07C271/52 , C07C311/17 , C07C311/18 , C07C2601/14 , C07D205/04 , C07D211/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/084 , C07D295/088 , C07D295/135
摘要： The present invention provides compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8 , A9, A10, U, V, W, m, n and p-are as indicated in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia and hyperlipemia.
摘要翻译： 本发明提供式（I）的化合物，其中A 1，A 2，S 3，S 4， ，A 5，A 6，A 7，A 8，A 9， A，U，V，W，m，n和p-如本说明书中所示，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症和高脂血症相关的疾病。
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