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20 条记录 (耗时 0.023 秒)

    Method for making mixed high purity (meth)acrylic anhydrides
    1.
    发明授权
    Method for making mixed high purity (meth)acrylic anhydrides 失效
    混合高纯度（甲基）丙烯酸酐的方法

    公开(公告)号：US06346650B1

    公开(公告)日：2002-02-12

    申请号：US09601240

    申请日：2000-07-31

    申请人： Jean-Michel Paul ,  Alain Riondel ,  Frédéric Fabis ,  Sylvain Rault

    发明人： Jean-Michel Paul ,  Alain Riondel ,  Frédéric Fabis ,  Sylvain Rault

    IPC分类号： C07C5156

    CPC分类号： C07C68/02 ,  C07C69/96

    摘要： The invention concerns a method consisting in making a mixed (meth)acrylic anhydride of formula (I) by reacting an alkaline (meth)acrylate of formula (II) and a chloroformate of formula (III), carrying out said reaction in an aqueous medium and in the absence of amines, the mol ratio chloroformate (III)/alkaline (meth)acrylate (II) being at least equal to 1.15. R1 represents H or CH3; R2 represents an alkyl, alkenyl, aryl, alkaryl or aralkyl residue; and M is an alkaline metal.

    摘要翻译： 本发明涉及通过使式（II）的碱式（甲基）丙烯酸酯与式（III）的氯甲酸酯在水性介质中进行所述反应而制备式（I）的混合（甲基）丙烯酸酐的方法 在不存在胺的情况下，氯甲酸酯（III）/碱性（甲基）丙烯酸酯（II）的摩尔比至少等于1.15。 R1表示H或CH3; R 2表示烷基，烯基，芳基，烷芳基或芳烷基残基; M是碱金属。

    Pyrrolo [1,2A] thieno [3,2-F] [1,4] diazepines
    6.
    发明授权
    Pyrrolo [1,2A] thieno [3,2-F] [1,4] diazepines 失效
    吡咯（1,2A）噻吩（3,2-F）（1,4）二氮杂

    公开(公告)号：US5153190A

    公开(公告)日：1992-10-06

    申请号：US665807

    申请日：1991-03-07

    申请人： Sylvain Rault ,  Michel Boulouard ,  Marie P. Foloppe ,  Max Robba ,  Beatrice Guardiola ,  Michelle Devissague

    发明人： Sylvain Rault ,  Michel Boulouard ,  Marie P. Foloppe ,  Max Robba ,  Beatrice Guardiola ,  Michelle Devissague

    IPC分类号： A61K31/55 ,  A61P3/06 ,  A61P3/08 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P25/28 ,  C07D495/14

    CPC分类号： C07D495/14

    摘要： The invention relates to pyrrolo [1,2-a] thieno [3,2-f][1,4]diazepine compounds of the formula (I) ##STR1## in which: R.sub.1 is hydrogen; alkyl optionally substituted with alkoxy, hydroxy, cycloalkyl, or phenyl; or alkyl- or arylsulfonyl; R.sub.2 is hydrogen, phenyl, or phenylalkyl; alkyl optionally substituted with hydroxyl, alkoxy, oxo, cycloalkyl or phenyl; or optionally substituted amino; R.sub.3 represents hydrogen or alkyl, and R.sub.4 and R.sub.5 independently represent: hydrogen, alkyl optionally substituted with alkoxy, cycloalkyl, or phenyl; or phenyl; their isomers, diastereoisomers and enantiomers as well as their addition salts with pharmaceutically-acceptable acids. The compounds are useful for treating cerebral ischemia, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, and hyperglycemia and are obtained in a few steps from the corresponding substituted 2-(1-pyrrolyl)thiophenes ##STR2## Y=--CHO or H; X= CN, CONH.sub.2, CH.sub.2 NHCOR.sub.2, or CH.sub.2 NH.sub.2.

    摘要翻译： 本发明涉及式（I）的吡咯并[1,2-a]噻吩并[3,2-f] [1,4]二氮杂化合物，其中：R1是氢; 任选被烷氧基，羟基，环烷基或苯基取代的烷基; 或烷基 - 或芳基磺酰基; R2是氢，苯基或苯基烷基; 任选被羟基，烷氧基，氧代，环烷基或苯基取代的烷基; 或任选取代的氨基; R3表示氢或烷基，R4和R5独立地表示：氢，任选被烷氧基，环烷基或苯基取代的烷基; 或苯基; 它们的异构体，非对映异构体和对映体以及它们与药学上可接受的酸的加成盐。 这些化合物可用于治疗脑缺血，高甘油三酯血症，高胆固醇血症，高脂血症和高血糖症，并且从相应的取代的2-（1-吡咯基）噻吩获得的几步中获得：Y = -CHO或H; X = CN，CONH 2，CH 2 NHCOR 2或CH 2 NH 2。