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1.发明申请CONTROLLED RELEASE ORAL FORMULATIONS OF ION CHANNEL MODULATING COMPOUNDS AND RELATED METHODS FOR PREVENTING ARRHYTHMIA 审中-公开离子通道调节化合物的控制释放口服制剂及相关方法预防脑脊液公开(公告)号：US20080312309A1
公开(公告)日：2008-12-18
申请号：US12114652
申请日：2008-05-02
IPC分类号： A61K31/4015 , G01N33/566
CPC分类号： A61K31/40 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/4808 , A61K31/4015 , A61K45/06 , C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides methods of treating and preventing arrhythmia and other diseases or disorders, using ion channel modulating compounds, including vernakalant hydrochloride. The present invention further provides controlled release oral formulations and dosages of vernakalant hydrochloride, which are effective in preventing arrhythmia. Certain methods and formulations of the present invention are adapted for the treatment and prevention of arrhythmia and other disease or disorders in subjects identified as having altered drug metabolism due to polymorphism of the gene encoding cytochrome P450 2D6.
摘要翻译： 本发明提供了使用离子通道调节化合物（包括盐酸维奈卡兰）来治疗和预防心律失常等疾病或病症的方法。 本发明进一步提供了有效预防心律失常的盐酸伐卡沙坦的控释口服制剂和剂量。 本发明的某些方法和制剂适于治疗和预防由于编码细胞色素P450 2D6的基因的多态性鉴定为具有改变的药物代谢的受试者的心律失常和其它疾病或病症。
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公开(公告)号：US07534790B2
公开(公告)日：2009-05-19
申请号：US11944282
申请日：2007-11-21
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M. C. Plouvier , Tao Sheng , Michael J. A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/426 , A61K31/403 , A61K31/4015 , A61K31/40 , C07D295/033 , C07D413/02 , C07D295/027 , C07D277/04 , C07D209/96 , C07D207/12
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US08207219B2
公开(公告)日：2012-06-26
申请号：US12689909
申请日：2010-01-19
IPC分类号： A61K31/40
CPC分类号： A61K31/40 , A61K31/455 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
摘要翻译： 用于治疗或预防心律失常的方法，组合物，给药方案和给药途径。 在这些方法中，可以通过向有需要的受试者施用离子通道调节化合物来减少或消除早期后消极和延长QT间期。 离子通道调节化合物可以是环烷基胺醚化合物，特别是环己胺醚化合物。 还描述了诱导早期后极化，延长QT间期和/或Torsades de Pointes的离子通道调节化合物和药物的组合物。
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公开(公告)号：US20110207730A1
公开(公告)日：2011-08-25
申请号：US12970532
申请日：2010-12-16
申请人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
发明人： Allen I. Bain , Gregory N. Beatch , Cindy J. Longley , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander B. Zolotoy
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/5375 , C07D207/325 , A61K31/40 , C07D413/02 , C07C211/38 , A61K31/135 , C07D241/06 , A61K31/4965 , C07D491/113 , A61K31/438 , C07D277/24 , A61K31/426 , A61P9/00 , C12N5/071
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译： 公开了离子通道调节化合物。 本发明的化合物可以掺入组合物和试剂盒中。 本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。
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公开(公告)号：US06740673B2
公开(公告)日：2004-05-25
申请号：US10144607
申请日：2002-05-13
IPC分类号： A61K31404
CPC分类号： C07D209/08 , C07C237/04
摘要： Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.
摘要翻译： 含有这些化合物并具有抗咳嗽活性的新型化合物和药物组合物，以及将其用于包括人在内的温血动物的方法。
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公开(公告)号：US06388095B1
公开(公告)日：2002-05-14
申请号：US09328541
申请日：1999-06-09
IPC分类号： C07D20914
CPC分类号： C07D209/08 , C07C237/04
摘要： Compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans.
摘要翻译： 含有这些化合物并具有抗咳嗽活性的化合物和药物组合物，以及将其用于包括人在内的温血动物的方法。
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公开(公告)号：US20120095073A1
公开(公告)日：2012-04-19
申请号：US13110574
申请日：2011-05-18
IPC分类号： A61K31/40 , A61P9/06 , C07D207/12
CPC分类号： A61K31/40 , A61K31/00 , A61K31/455 , A61K31/4965 , A61K31/519 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D207/24 , C07D207/27 , C07D277/04 , C07D295/096 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g. atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
摘要翻译： 用于治疗或预防心律失常的方法，组合物，给药方案和给药途径。 在这些方法中，可以通过向有需要的受试者施用离子通道调节化合物来减少或消除心律失常（例如房颤，心房扑动，早期去极化和QT间期延长）。 离子通道调节化合物可以是环烷基胺醚化合物，特别是环己胺醚化合物。 还描述了诱导早期后极化，延长QT间期和/或Torsades de Pointes的离子通道调节化合物和药物的组合物。
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公开(公告)号：US20110118329A1
公开(公告)日：2011-05-19
申请号：US12900330
申请日：2010-10-07
申请人： Gregory N. Beatch , Alan M. Ezrin
发明人： Gregory N. Beatch , Alan M. Ezrin
CPC分类号： A61K31/455 , A61K31/40 , A61K31/4965 , A61K31/519 , C07D207/12
摘要： Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one or more ion channel modulating compounds to a subject, where the ion channel modulating compound or compounds produce specific plasma levels in the subject. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds.
摘要翻译： 用于治疗或预防心律失常的方法，制剂，给药方案和给药途径，包括治疗或预防心房颤动。 在这些方法中，通过向受试者施用一种或多种离子通道调节化合物来治疗或预防疾病或病症，其中离子通道调节化合物或化合物在受试者中产生特异性血浆水平。 离子通道调节化合物可以是环烷基胺醚化合物，特别是环己胺醚化合物。
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公开(公告)号：US20100056603A1
公开(公告)日：2010-03-04
申请号：US12412010
申请日：2009-03-26
申请人： Gregory N. Beatch , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
发明人： Gregory N. Beatch , Bertrand M.C. Plouvier , Tao Sheng , Michael J.A. Walker , Richard A. Wall , Sandro L. Yong , Jeff Jiqun Zhu , Alexander R. Zolotoy
CPC分类号： A61K31/40 , A61K9/0019 , A61K31/4015 , C07D209/36
摘要： Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
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公开(公告)号：US07507545B2
公开(公告)日：2009-03-24
申请号：US10914841
申请日：2004-08-09
申请人： David Fedida , Gregory N. Beatch , Alan M. Ezrin , Peter Orth
发明人： David Fedida , Gregory N. Beatch , Alan M. Ezrin , Peter Orth
IPC分类号： G01N33/53
CPC分类号： A61K31/40 , A61K31/00 , A61K31/455 , A61K31/4965 , A61K31/519 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D207/24 , C07D207/27 , C07D277/04 , C07D295/096 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, arrythmias (e.g. atrial fibrillation, atrial flutter, early afterdepolarizations and prolongation of QT interval) may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
摘要翻译： 用于治疗或预防心律失常的方法，组合物，给药方案和给药途径。 在这些方法中，可以通过向有需要的受试者施用离子通道调节化合物来减少或消除心律失常（例如房颤，心房扑动，早期去极化和QT间期延长）。 离子通道调节化合物可以是环烷基胺醚化合物，特别是环己胺醚化合物。 还描述了诱导早期后极化，延长QT间期和/或Torsades de Pointes的离子通道调节化合物和药物的组合物。
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