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    Process to treat avascular necrosis (AVN) with osteoinductive materials
    1.
    发明申请
    Process to treat avascular necrosis (AVN) with osteoinductive materials 审中-公开
    用骨诱导材料治疗无血管性坏死（AVN）的方法

    公开(公告)号：US20060057184A1

    公开(公告)日：2006-03-16

    申请号：US10942042

    申请日：2004-09-16

    申请人： Jeffrey Nycz ,  William McKay ,  Jon Serbousek

    发明人： Jeffrey Nycz ,  William McKay ,  Jon Serbousek

    IPC分类号： A61K38/18 ,  A61F2/00

    CPC分类号： A61K38/1875 ,  A61B17/58 ,  A61F2/2814

    摘要： A method of treating avascular necrosis (“AVN”) comprising administering one or more osteoinductive formulations to the site of AVN disease progression. The method involves the combination of a core decompression technique, followed by the introduction of one or more osteoinductive formulations into the decompression core, and concluding with capping of the lateral aspect of the decompression core with a femoral core cap. The osteoinductive formulations of the invention comprise one or more osteoinductive agents and suitable carrier molecules. The femoral core cap retains the osteoinductive formulation within the decompression core, thereby preventing leakage of the osteoinductive formulation from the decompression core. The method of the invention optionally comprises introduction of autograft or allograft with the osteoinductive formulations of the invention. The method of the invention further optionally comprises incorporation of sustained release compositions to provide extended periods of osteogenesis.

    摘要翻译： 一种治疗无血管性坏死（“AVN”）的方法，包括向AVN疾病进展的部位施用一种或多种骨诱导性制剂。 该方法涉及核心减压技术的组合，接着将一种或多种骨诱导性制剂引入减压核心，并且用股骨芯帽盖住减压芯的侧面方面。 本发明的骨诱导制剂包含一种或多种成骨诱导剂和合适的载体分子。 股骨芯帽将骨诱导制剂保留在减压芯内，从而防止骨诱导制剂从减压芯渗漏。 本发明的方法任选地包括用本发明的骨诱导制剂引入自体移植物或同种异体移植物。 本发明的方法还任选地包括并入缓释组合物以提供延长的成骨期。

    Porous coated bone screw
    5.
    发明授权
    Porous coated bone screw 失效
    多孔涂层骨螺钉

    公开(公告)号：US5098434A

    公开(公告)日：1992-03-24

    申请号：US619029

    申请日：1990-11-28

    申请人： Jon Serbousek

    发明人： Jon Serbousek

    IPC分类号： A61B17/86 ,  A61F2/30 ,  A61L31/14

    CPC分类号： A61B17/866 ,  A61B17/8625 ,  A61F2/30767 ,  A61L31/146 ,  A61F2002/3085 ,  Y10S606/907

    摘要： A bone screw is disclosed for joining bone fragments or for mounting a prosthetic component onto an underlying bone. The bone screw includes a head and an elongated cylindrical shank which is integral with and extends from the head. The shank includes a threaded member and a shoulder member connecting the threaded member and the head, the shoulder member having an outer surface with a porous medium thereon for encouraging bone ingrowth fixation. The outer diameter of the shoulder member is greater than the diameter of a bore of the bone into which the screw is to be threadedly engaged. The head of the screw is provided with a coupling member engageable by a tool for selectively rotating the shank to advance the screw into the bone. As the bone screw is advanced toward a fully seated position, the shoulder member with the porous medium thereon engages the bone in a fitting manner which may be described as a "scratch fit". Initial loosening of the bone screw due to the viscoelastic relaxation of the bone tissue following fixation is thereby largely inhibited and long term loosening of the bone screw is also inhibited by providing an interface onto which or into which bone tissue can grow to stabilize the repair site or the implanted component.

    摘要翻译： 公开了用于接合骨碎片或用于将假体组件安装到下面的骨上的骨螺钉。 骨螺钉包括头部和与头部成一体并从头部延伸的细长圆筒形柄部。 所述柄包括螺纹构件和连接所述螺纹构件和所述头部的肩部构件，所述肩部构件具有外表面，其上具有用于鼓励骨向内生长固定的多孔介质。 肩部构件的外径大于螺钉与其螺纹接合的骨的孔的直径。 螺钉的头部设置有可由工具接合的联接构件，用于选择性地旋转柄以将螺钉推进到骨中。 当骨螺钉朝向完全就位的位置前进时，其上具有多孔介质的肩部构件以可被描述为“划痕”的配合方式接合骨骼。 因此，固定后由于骨组织的粘弹性松弛引起的骨螺钉的初始松动因此受到很大的抑制，并且通过提供骨组织可以生长到其中或可以生长以稳定修复部位的界面也可以抑制骨螺钉的长期松动 或植入的部件。

    Vented directional delivery cannula with openings of different size for use with flowable materials and method for use thereof
    6.
    发明申请
    Vented directional delivery cannula with openings of different size for use with flowable materials and method for use thereof 审中-公开
    具有不同尺寸开口的通气式定向输送套管，用于可流动材料及其使用方法

    公开(公告)号：US20070255230A1

    公开(公告)日：2007-11-01

    申请号：US11412345

    申请日：2006-04-27

    申请人： Jeffrey Gross ,  Jon Serbousek

    发明人： Jeffrey Gross ,  Jon Serbousek

    IPC分类号： A61M5/32

    CPC分类号： A61B17/8811 ,  A61M25/007

    摘要： In one preferred aspect, a cannula is provided that has openings of different size to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different size into a patient.

    摘要翻译： 在一个优选的方面，提供具有不同尺寸的开口的插管，以允许外科医生选择性地控制可流动材料通过插管并进入患者的分布模式。 在另一方面，提供了一种方法，用于选择性地控制可流动材料通过具有不同尺寸开口的插管到患者体内的分布模式。

    Polymeric wrap for in vivo delivery of osteoinductive formulations
    7.
    发明申请
    Polymeric wrap for in vivo delivery of osteoinductive formulations 审中-公开
    用于体内递送骨诱导制剂的聚合物包装

    公开(公告)号：US20060045902A1

    公开(公告)日：2006-03-02

    申请号：US10931198

    申请日：2004-09-01

    申请人： Jon Serbousek

    发明人： Jon Serbousek

    IPC分类号： A61F2/02 ,  A61F2/28

    CPC分类号： A61L27/34 ,  A61F2/30907 ,  A61F2/34 ,  A61F2/36 ,  A61F2/367 ,  A61F2002/2817 ,  A61F2002/2867 ,  A61F2002/30064 ,  A61F2002/30678 ,  A61F2002/30919 ,  A61F2002/30929 ,  A61F2310/00365 ,  A61F2310/0097 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/608

    摘要： The application discloses a polymeric wrap having one or more osteoinductive formulations, wherein each osteoinductive formulation comprises one or more osteoinductive agent(s). In one embodiment, the osteoinductive formulation(s) is contained within a biodegradable polymer sheet. In another embodiment of the invention, the polymeric wrap comprises at least two or more individual biodegradable polymer sheets or layers optionally comprising osteoinductive formulation(s) comprising at least one osteoinductive agent. The osteoinductive formulations are available in immediate or sustained release formulations. The method further relates to preventing and treating osteolytic lesions formed following implantation of an orthopaedic device or other implant.

    摘要翻译： 本申请公开了一种具有一种或多种成骨诱导剂的聚合物包衣，其中每种骨诱导性制剂包含一种或多种骨诱导剂。 在一个实施方案中，骨诱导制剂包含在可生物降解的聚合物片材内。 在本发明的另一个实施方案中，聚合物包层包含至少两个或多个单独的可生物降解的聚合物片或层，任选地包含至少一种骨诱导剂的骨诱导制剂。 骨诱导制剂可用于即时或持续释放制剂。 该方法还涉及预防和治疗在植入矫形装置或其它植入物之后形成的溶骨性病变。