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公开(公告)号：US07619009B2
公开(公告)日：2009-11-17
申请号：US11462799
申请日：2006-08-07
CPC分类号： A61F2/442 , A61F2002/444 , A61L27/16 , A61L27/52 , A61L2430/38 , C08J3/09 , C08J2329/04 , C08L29/04 , Y10S516/902 , Y10S524/916 , C08L2666/26
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gellation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
摘要翻译： 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制备乙烯基聚合物凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性质的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供了通过可控制的粘弹性溶液凝胶制备的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。
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公开(公告)号：US07776352B2
公开(公告)日：2010-08-17
申请号：US11462813
申请日：2006-08-07
CPC分类号： A61F2/442 , A61F2002/444 , A61L27/16 , A61L27/52 , A61L2430/38 , C08J3/09 , C08J2329/04 , C08L29/04 , Y10S516/902 , Y10S524/916 , C08L2666/26
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
摘要翻译： 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制备乙烯基聚合物水凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。
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公开(公告)号：US07485670B2
公开(公告)日：2009-02-03
申请号：US10771852
申请日：2004-02-04
CPC分类号： A61F2/442 , A61F2002/444 , A61L27/16 , A61L27/52 , A61L2430/38 , C08J3/09 , C08J2329/04 , C08L29/04 , Y10S516/902 , Y10S524/916 , C08L2666/26
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
摘要翻译： 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制备乙烯基聚合物凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。
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公开(公告)号：US07745532B2
公开(公告)日：2010-06-29
申请号：US10631491
申请日：2003-07-31
CPC分类号： C08J3/09 , A61K9/0024 , C08J2329/04
摘要： The preferred embodiments of the present invention provide polymer compositions and methods for controlling a property of a resultant gel. A preferred method includes dissolving a vinyl polymer in a first solvent to form a solution; and contacting the vinyl polymer solution in a suitable volume of at least one immersion solvent comprising a second solvent to cause gelation. In preferred embodiments, the invention provides poly(vinyl alcohol) compositions and methods that produce physically crosslinked hydrogels that have tunable physical properties. Also provided are articles of manufacture such as prosthetic intervertebral disks and contact lenses.
摘要翻译： 本发明的优选实施方案提供聚合物组合物和控制所得凝胶性质的方法。 优选的方法包括将乙烯基聚合物溶解在第一溶剂中以形成溶液; 并使乙烯基聚合物溶液在合适体积的包含第二溶剂的至少一种浸渍溶剂中接触以引起凝胶化。 在优选的实施方案中，本发明提供聚（乙烯醇）组合物和产生具有可调谐物理性质的物理交联水凝胶的方法。 还提供诸如假肢椎间盘和隐形眼镜的制品。
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公开(公告)号：US07048963B2
公开(公告)日：2006-05-23
申请号：US10306825
申请日：2002-11-27
IPC分类号： B05D3/12
CPC分类号： A61L27/24 , A61L27/38 , A61L27/50 , A61L2400/18 , B29C41/045 , B29C41/22 , B29C41/36 , B29C41/52 , B29C47/0004 , B29C47/0021 , B29C67/0003 , B29C67/24 , B29C2037/90 , B29K2089/00 , B29K2995/005 , C08L89/06 , D01D5/18 , D01D5/38 , D01F4/00
摘要： This invention includes a method of producing a thin, oriented layer of polymer material. The material is preferably produced by the method of introducing a shearing flow to a free surface in a predominantly monomeric solution of the self-assembling polymer sub-units, and inducing polymerization or growth of the monomer while in this shearing flow. The system for forming the oriented layer of material provides relative movement between a delivery system and the substrate on or over which the material is deposited. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. Preferred embodiments include either angular or linear relative movement between the delivery system and the substrate.
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6.发明授权Apparatus and methods for measuring extensional rheological properties of a material 有权用于测量材料的拉伸流变性质的装置和方法公开(公告)号：US06711941B2
公开(公告)日：2004-03-30
申请号：US09928643
申请日：2001-08-13
IPC分类号： G01N1100
CPC分类号： G01N11/00 , G01N3/08 , G01N13/02 , G01N33/442 , G01N2011/004 , G01N2203/0092
摘要： Apparatus and methods for evaluating the rheological properties of Newtonian and non-Newtonian liquids and melts employs the principle of capillary breakup following rapid stretching of the fluid between two plates. The apparatus includes opposed surfaces defining a sample site disposed therebetween. A liquid sample undergoes an extensional deformation between the opposed surfaces which separate using a user-defined motion profile. The time profile of the diameter of the liquid filament is monitored and recorded as a function of time. Preferred embodiments of the present invention include data analysis of the diameter of the filament as a function of time which provides information regarding rheological parameters including, but not limited to, extensional viscosity versus strain.
摘要翻译： 用于评估牛顿和非牛顿液体和熔体的流变性质的装置和方法采用在两块板之间快速拉伸流体之后毛细管断裂的原理。 该装置包括限定其间设置的样品位置的相对表面。 液体样品在使用用户定义的运动曲线分离的相对表面之间经历拉伸变形。 作为时间的函数监视和记录液体长丝的直径的时间曲线。 本发明的优选实施例包括作为时间的函数的长丝的直径的数据分析，其提供关于流变参数的信息，包括但不限于拉伸粘度对应变。
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公开(公告)号：US08637063B2
公开(公告)日：2014-01-28
申请号：US13132507
申请日：2009-12-07
CPC分类号： C08F218/08 , C08F8/12 , C08F2810/20 , C08G81/025 , C08F118/08 , C08F218/16 , C08F299/026
摘要： The invention provides methods of making hydrolyzed cross-linked polyvinyl alcohol (PVA) hydrogels by polymerizing vinyl acetate (VAc) monomers to polyvinyl acetate (PVAc) polymer network by chemical-crosslinking and hydrolysis. The invention also provides methods for including pendant chains in the hydrogel during the polymerization process. Materials produced and use of the cross-linked hydrolyzed PVA hydrogels also are disclosed herein.
摘要翻译： 本发明提供了通过化学交联和水解将乙酸乙烯酯（VAc）单体聚合到聚乙酸乙烯酯（PVAc）聚合物网络上来制备水解的交联聚乙烯醇（PVA）水凝胶的方法。 本发明还提供了在聚合过程中将侧链包含在水凝胶中的方法。 所生产的材料和使用的交联水解PVA水凝胶也在本文中公开。
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公开(公告)号：US20080274161A1
公开(公告)日：2008-11-06
申请号：US11419142
申请日：2006-05-18
CPC分类号： A61L27/52 , A61L31/145 , B01J13/0065 , B01J13/0069 , B01J13/046
摘要： The invention provides fabricated hydrogels, hydrogel particles, hydrogel containing compositions, and methods of making the same. The invention also provides methods of implanting, injecting, or administering the hydrogels, hydrogel particles, or the hydrogel containing compositions to treat a subject in need. Methods of crosslinking pre-solidified or pre-gelled hydrogel particles and making crosslinked hydrogels, crosslinked hydrogel particles, and crosslinked hydrogel containing compositions also are disclosed herein.
摘要翻译： 本发明提供制造的水凝胶，水凝胶颗粒，含水凝胶组合物及其制备方法。 本发明还提供了植入，注射或施用水凝胶，水凝胶颗粒或含水凝胶的组合物以治疗有需要的受试者的方法。 交联预固化或预胶凝的水凝胶颗粒和制备交联的水凝胶，交联的水凝胶颗粒和交联的含水凝胶的组合物的交联方法也在本文中公开。
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公开(公告)号：US09394384B2
公开(公告)日：2016-07-19
申请号：US11916703
申请日：2005-09-27
申请人： Orhun K. Muratoglu , Jeeyoung Choi , Hatice Bodugoz-Senturk , Gavin J. C. Braithwaite , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Jeeyoung Choi , Hatice Bodugoz-Senturk , Gavin J. C. Braithwaite , Stephen H. Spiegelberg
IPC分类号： A61F2/30 , A61F2/32 , A61L31/04 , C08F6/10 , A61L27/52 , C08J3/075 , C08L29/04 , A61F2/38 , C08L71/02
CPC分类号： C08F6/10 , A61F2/30756 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2002/30754 , A61L27/52 , C08J3/075 , C08J2329/04 , C08L29/04 , C08L71/02 , C08L2666/14
摘要： The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making crosslinked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.
摘要翻译： 本发明提供了制造的韧性水凝胶，含水凝胶的组合物及其制备方法。 本发明还提供了植入或施用韧性水凝胶或含水凝胶组合物以治疗有需要的受试者的方法。 交联预固化或预胶凝的水凝胶颗粒和制备交联的韧性水凝胶以及交联的含有韧性水凝胶的组合物的方法也在本文中公开。
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