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公开(公告)号：US06846084B2
公开(公告)日：2005-01-25
申请号：US10646432
申请日：2003-08-22
CPC分类号： G02B21/32 , G02B27/1086 , G02B27/42 , G02B27/4244 , G02B27/425
摘要： A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.
摘要翻译： 用于控制光阱阵列的方法和装置，并且使用在光谱的可见部分中的光形成粒子阵列。 该方法和装置提供激光器和时变衍射光学元件，以允许光阱阵列的动态控制和随后的粒子阵列的控制以及使用多个光阱的操纵单个物体的能力。 通过避免与下层材料中的强吸收相关的波长，用连续波激光产生光阱，优化各陷阱的效率，并在多个点捕获扩展样本，可以最大限度地减少有害非线性光学过程的速率。
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公开(公告)号：US06626546B2
公开(公告)日：2003-09-30
申请号：US10186807
申请日：2002-07-01
IPC分类号： G02B2700
CPC分类号： G02B21/32 , G02B27/1086 , G02B27/42 , G02B27/4244 , G02B27/425
摘要： A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.
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公开(公告)号：US20080316575A1
公开(公告)日：2008-12-25
申请号：US12155503
申请日：2008-06-05
CPC分类号： G02B21/32
摘要： A method and system for correcting aberrations in a beam of light including correcting for effects from an undiffracted portion of an input beam. The method and system includes (1) a component for providing a beam of light; (2) a component for applying a diffraction grating pattern to the beam of light to establish an optical gradient to form an optical trap; (3) component for measuring aberration in the beam of light having the applied diffraction grating pattern; (4) component for calculating a phase-shifting diffraction grating encoding the aberration; and (5) component for projecting the phase-shifting diffraction grating in conjunction with the diffraction grating pattern characteristic of the optical trap. The method and system also includes (1) providing an input beam of light; (2) applying a diffractive grating pattern to the input beam of light to establish a diffracted portion, apart from an undiffracted portion, to form at least one optical trap; (3) operating on both the diffracted portion and the undiffracted portion to bring the light to focus out of the focal plane; and (4) operating on the diffracted portion of the input beam of light (the optical trap) to modify focus of the diffracted portion relative to the undiffracted portion to bring the diffracted portion into focus in the focal plane.
摘要翻译： 一种用于校正光束中的像差的方法和系统，包括校正来自输入光束的未衍射部分的效果。 该方法和系统包括（1）用于提供光束的部件; （2）用于将衍射光栅图案应用于光束以建立光学梯度以形成光阱的部件; （3）用于测量具有施加的衍射光栅图案的光束中的像差的分量; （4）分量，用于计算编码像差的相移衍射光栅; 以及（5）用于将相移衍射光栅与光阱的衍射光栅图案特性相结合的部件。 该方法和系统还包括（1）提供输入光束; （2）将衍射光栅图案施加到所述输入光束以建立远离未衍射部分的衍射部分，以形成至少一个光阱; （3）在衍射部分和未衍射部分上操作以使光聚焦在焦平面之外; 和（4）在输入光束（光阱）的衍射部分上操作，以改变衍射部分相对于未衍射部分的焦点，以使衍射部分在焦平面中聚焦。
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公开(公告)号：US07104659B2
公开(公告)日：2006-09-12
申请号：US11010004
申请日：2004-12-10
CPC分类号： G02B21/32 , G02B27/1086 , G02B27/42 , G02B27/4244 , G02B27/425
摘要： A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.
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公开(公告)号：US06995351B2
公开(公告)日：2006-02-07
申请号：US11059876
申请日：2005-02-17
IPC分类号： H01J40/14
CPC分类号： H05H3/04 , B01F13/0052 , B01F15/00551 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2400/0409 , B01L2400/0454 , F04B19/006 , G01N30/00 , G01N30/02 , G01N2015/149 , G02B21/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , B01D2015/3895
摘要： A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales.
摘要翻译： 一种用于在任意三维配置中创建大量高质量光阱的方法，并在计算机控制下动态地重构陷阱。 该方法使用计算机产生的衍射光学元件将一个或多个光学镊子转换成一个或多个光学旋转。 该方法涉及将光学旋涡技术与全息光学镊子技术组合以产生任意配置的多个光学旋涡。 该方法还涉及通过光学旋涡在捕获的颗粒中诱导的旋转，以将颗粒簇组装成功能微机械，驱动先前组装的微机械，通过微流体通道泵送流体，以控制流体通过微流体通道，将微流体中的流体混合 通道，运输粒子，对粒子进行分类，并对长度尺度上的物质进行其他相关的操作和转换。
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公开(公告)号：US06737634B2
公开(公告)日：2004-05-18
申请号：US10050213
申请日：2002-01-16
IPC分类号： G01V800
CPC分类号： H05H3/04 , B01F13/0052 , B01F15/00551 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2400/0409 , B01L2400/0454 , F04B19/006 , G01N30/00 , G01N30/02 , G01N2015/149 , G02B21/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , B01D2015/3895
摘要： A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales
摘要翻译： 一种用于在任意三维配置中创建大量高质量光阱的方法，并在计算机控制下动态地重构陷阱。 该方法使用计算机产生的衍射光学元件将一个或多个光学镊子转换成一个或多个光学旋转。 该方法涉及将光学旋涡技术与全息光学镊子技术组合以产生任意配置的多个光学旋涡。 该方法还涉及通过光学旋涡在捕获的颗粒中诱导的旋转，以将颗粒簇组装成功能微机械，驱动先前组装的微机械，通过微流体通道泵送流体，以控制流体通过微流体通道，将微流体中的流体混合 通道，运输粒子，对粒子进行分类，并对长度尺度上的物质进行其他相关的操作和转换
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公开(公告)号：US07176445B2
公开(公告)日：2007-02-13
申请号：US11266989
申请日：2005-11-04
IPC分类号： H01J40/14
CPC分类号： H05H3/04 , B01F13/0052 , B01F15/00551 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2400/0409 , B01L2400/0454 , F04B19/006 , G01N30/00 , G01N30/02 , G01N2015/149 , G02B21/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , B01D2015/3895
摘要： A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales.
摘要翻译： 一种用于在任意三维配置中创建大量高质量光阱的方法，并在计算机控制下动态地重构陷阱。 该方法使用计算机产生的衍射光学元件将一个或多个光学镊子转换成一个或多个光学旋转。 该方法涉及将光学旋涡技术与全息光学镊子技术组合以产生任意配置的多个光学旋涡。 该方法还涉及通过光学旋涡在捕获的颗粒中诱导的旋转，以将颗粒簇组装成功能微机械，驱动先前组装的微机械，通过微流体通道泵送流体，以控制流体通过微流体通道，将微流体中的流体混合 通道，运输粒子，对粒子进行分类，并对长度尺度上的物质进行其他相关的操作和转换。
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公开(公告)号：US06858833B2
公开(公告)日：2005-02-22
申请号：US10847042
申请日：2004-05-17
CPC分类号： H05H3/04 , B01F13/0052 , B01F15/00551 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2400/0409 , B01L2400/0454 , F04B19/006 , G01N30/00 , G01N30/02 , G01N2015/149 , G02B21/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , B01D2015/3895
摘要： A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales.
摘要翻译： 一种用于在任意三维配置中创建大量高质量光阱的方法，并在计算机控制下动态地重构陷阱。 该方法使用计算机产生的衍射光学元件将一个或多个光学镊子转换成一个或多个光学旋转。 该方法涉及将光学旋涡技术与全息光学镊子技术组合以产生任意配置的多个光学旋涡。 该方法还涉及通过光学旋涡在捕获的颗粒中诱导的旋转，以将颗粒簇组装成功能微机械，驱动先前组装的微机械，通过微流体通道泵送流体，以控制流体通过微流体通道，将微流体中的流体混合 通道，运输粒子，对粒子进行分类，并对长度尺度上的物质进行其他相关的操作和转换。
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公开(公告)号：US07075060B2
公开(公告)日：2006-07-11
申请号：US11041640
申请日：2005-01-24
IPC分类号： H05H3/04
CPC分类号： G03H1/0005 , F04B19/006 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H1/30 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G03H2227/03 , H05H3/04
摘要： A method of use for holographic optical traps or gradients in which repetitive cycling of a small number of appropriately designed arrays of traps are used for general and very complex manipulations of particles and volumes of matter. Material transport results from a process resembling peristaltic pumping, with the sequence of holographically-defined trapping or holding manifolds resembling the states of a physical peristaltic pump.
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公开(公告)号：US07232989B2
公开(公告)日：2007-06-19
申请号：US11522665
申请日：2006-09-18
申请人： David G. Grier , Jennifer E. Curtis
发明人： David G. Grier , Jennifer E. Curtis
IPC分类号： H01S1/00
CPC分类号： G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32
摘要： A method and system for generating modulated optical vortices. Optical vortices can be used for a variety of applications, such as applying controlled torque or controlled force patterns to objects from a few nanometers to hundreds of micrometers in size. Numerous optical modes of optical vortices can be created to meet virtually any desired need in manipulating of objects. Furthermore, one can modify the wavefront of a beam of light in a specific way to create a new type of optical trap useful for manipulating mesoscopic materials. When the modified beam is brought to a focus, the resulting optical trap exerts forces transverse to the optical axis that can be used to transport mesoscopic matter such as nanoclusters, colloidal particles, and biological cells.
摘要翻译： 一种用于产生调制光学旋涡的方法和系统。 光学旋涡可用于各种应用，例如将受控扭矩或受控力图案应用于尺寸从几纳米到几百微米的物体。 可以创建光学旋涡的许多光学模式，以满足在操作物体时几乎任何所需的需要。 此外，可以以特定方式修改光束的波前，以产生用于操纵介观材料的新型光阱。 当修改的光束被聚焦时，所产生的光阱被施加横向于光轴的力，该光轴可用于传输诸如纳米团簇，胶体粒子和生物细胞的介观物质。
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