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    Nitric oxide-producing hydrogel materials
    6.
    发明授权
    Nitric oxide-producing hydrogel materials 失效

    公开(公告)号：US07052711B2

    公开(公告)日：2006-05-30

    申请号：US10129418

    申请日：2001-09-04

    申请人： Jennifer L. West ,  Kristyn Simcha Masters

    发明人： Jennifer L. West ,  Kristyn Simcha Masters

    IPC分类号： A61F2/02 ,  A61K9/14

    CPC分类号： A61K9/06 ,  A61F2/82 ,  A61K9/0019 ,  A61K31/00 ,  A61K33/00 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6903

    摘要： Hydrogels releasing or producing NO, most preferably polymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The polymeric materials can be formed into films, coatings, or microparticles for application to medical devices, such as stents, vascular grafts and catheters. The polymeric materials can also be applied directly to biological tissues and can be polymerized in situ. The hydrogels are formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.

    Quantum Dot Probes
    7.
    发明申请
    Quantum Dot Probes 审中-公开
    量子点探针

    公开(公告)号：US20080241071A1

    公开(公告)日：2008-10-02

    申请号：US12013215

    申请日：2008-01-11

    申请人： Jennifer L. West ,  Rebekah A. Drezek

    发明人： Jennifer L. West ,  Rebekah A. Drezek

    IPC分类号： A61K49/00 ,  G01N21/64

    CPC分类号： G01N21/6428 ,  B82Y15/00 ,  G01N33/587 ,  G01N33/588

    摘要： Novel nanoparticulate compositions of luminescent probes, as well as methods of using such compositions and systems comprising such compositions are provided. One such composition comprises at least one probe comprising a quantum dot, at least one metal nanoparticle, and at least one tether that is attached to the quantum dot and to the at least one metal nanoparticle. One such method comprises providing at least one such probe, introducing the at least one probe into a subject; and detecting luminescence from the at least one probe in the subject. One such system comprises at least one such probe and a detector capable of detecting luminescence from the quantum dot, wherein the detector is positioned in relation to the at least one probe such that luminescence can be detected.

    摘要翻译： 提供了新型的发光探针纳米颗粒组合物，以及使用这些组合物和包含这些组合物的体系的方法。 一种这样的组合物包含至少一种包含量子点，至少一种金属纳米颗粒和至少一个连接到量子点和至少一种金属纳米颗粒的系链的探针。 一种这样的方法包括提供至少一个这样的探针，将至少一个探针引入受试者; 以及检测来自所述受试者中的所述至少一个探针的发光。 一个这样的系统包括至少一个这样的探针和能够检测来自量子点的发光的检测器，其中检测器相对于至少一个探针定位，使得可以检测发光。

    Nitric oxide-producing hydrogel materials
    8.
    发明授权
    Nitric oxide-producing hydrogel materials 失效
    产生一氧化氮的水凝胶材料

    公开(公告)号：US07279176B1

    公开(公告)日：2007-10-09

    申请号：US09653406

    申请日：2000-09-01

    申请人： Jennifer L. West ,  Kristyn Simcha Bohl

    发明人： Jennifer L. West ,  Kristyn Simcha Bohl

    IPC分类号： A61F2/00 ,  A61K9/14

    CPC分类号： A61K9/06 ,  A61F2/82 ,  A61K9/0019 ,  A61K31/00 ,  A61K33/00 ,  A61K47/58 ,  A61K47/60 ,  A61K47/6903

    摘要： Hydrogels releasing or producing NO, most preferably photopolymerizable biodegradable hydrogels capable of releasing physiological amounts of NO for prolonged periods of time, are applied to sites on or in a patient in need of treatment thereof for disorders such as restenosis, thrombosis, asthma, wound healing, arthritis, penile erectile dysfunction or other conditions where NO plays a significant role. The hydrogels are typically formed of macromers, which preferably include biodegradable regions, and have bound thereto groups that are released in situ to elevate or otherwise modulate NO levels at the site where treatment is needed. The macromers can form a homo or hetero-dispersion or solution, which is polymerized to form a hydrogel material, that in the latter case can be a semi-interpenetrating network or interpenetrating network. Compounds to be released can be physically entrapped, covalently or ionically bound to macromer, or actually form a part of the polymeric material. The hydrogel can be formed by ionic and/or covalent crosslinking. Other active agents, including therapeutic, prophylactic, or diagnostic agents, can also be included within the polymeric material.

    摘要翻译： 释放或产生NO，最优选能够长时间释放生理量的NO的可光聚合的可生物降解的水凝胶的水凝胶被施用于需要治疗的患者或患者的位置，例如再狭窄，血栓形成，哮喘，伤口愈合 ，关节炎，阴茎勃起功能障碍或其他NO起重要作用的病症。 水凝胶通常由大分子单体形成，其优选包括可生物降解的区域，并且与其原有结合的基团结合以在需要治疗的部位升高或以其他方式调节NO水平。 大分子单体可以形成均聚或异质分散体或溶液，其被聚合以形成水凝胶材料，在后一种情况下可以是半互穿网络或互穿网络。 待释放的化合物可以被物理截留，共价或离子键结合到大分子单体上，或实际上形成聚合物材料的一部分。 水凝胶可以通过离子和/或共价交联形成。 其它活性剂，包括治疗剂，预防剂或诊断剂也可以包括在聚合物材料内。