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公开(公告)号：US20110306588A1
公开(公告)日：2011-12-15
申请号：US13106718
申请日：2011-05-12
申请人： Jennifer R. Allen , Daniel B. Horne , Essa Hu , Matthew R. Kaller , Holger Monenschein , Thomas T. Nguyen , Andreas Reichelt , Robert M. Rzasa
发明人： Jennifer R. Allen , Daniel B. Horne , Essa Hu , Matthew R. Kaller , Holger Monenschein , Thomas T. Nguyen , Andreas Reichelt , Robert M. Rzasa
IPC分类号： A61K31/497 , C07D413/14 , C07D491/107 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/551 , A61K31/498 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/00 , A61P25/14 , A61P25/24 , A61P25/30 , C07D401/14
CPC分类号： C07D491/107 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/10
摘要： Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 杂环氧基杂环基化合物和含有它们的组合物，以及这些化合物的制备方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。
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2.发明申请公开(公告)号：US20130079325A1
公开(公告)日：2013-03-28
申请号：US13676826
申请日：2012-11-14
申请人： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
发明人： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
IPC分类号： C07D413/14 , C07D401/14 , C07D401/12
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
摘要： Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
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公开(公告)号：US08497265B2
公开(公告)日：2013-07-30
申请号：US13106718
申请日：2011-05-12
申请人： Jennifer R. Allen , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Holger Monenschein , Thomas T. Nguyen , Andreas Reichelt , Robert M. Rzasa
发明人： Jennifer R. Allen , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Holger Monenschein , Thomas T. Nguyen , Andreas Reichelt , Robert M. Rzasa
IPC分类号： C07D241/18 , C07D413/14 , C07D401/14 , A61K31/5355 , A61K31/497 , A61P3/04 , A61P3/10 , A61P25/18
CPC分类号： C07D491/107 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/10
摘要： Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 杂环氧基杂环基化合物和含有它们的组合物，以及这些化合物的制备方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。
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4.发明授权公开(公告)号：US08318718B2
公开(公告)日：2012-11-27
申请号：US12619573
申请日：2009-11-16
申请人： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
发明人： Jennifer R. Allen , Biswas Kaustav , Frank Chavez , Ning Chen , Frenel Fils De Morin , James R. Falsey , Michael J. Frohn , Paul E. Harrington , Daniel B. Horne , Essa Hu Harrington , Matthew R. Kaller , Roxanne Kunz , Holger Monenschein , Thomas T. Nguyen , Alexander J. Pickrell , Andreas Reichelt , Shannon Rumfelt , Robert M. Rzasa , Kelvin Sham , Guomin Yao
IPC分类号： A61K31/4439 , A61K31/437 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/397 , C07D401/12 , C07D471/04 , C07D473/00 , C07D413/14 , C07D401/14 , A61P25/00
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , C07D473/00
摘要： Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
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公开(公告)号：US08778941B2
公开(公告)日：2014-07-15
申请号：US13529880
申请日：2012-06-21
申请人： James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Holger Monenschein , Thomas T. Nguyen , Nobuko Nishimura , Wenge Zhong
发明人： James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Holger Monenschein , Thomas T. Nguyen , Nobuko Nishimura , Wenge Zhong
IPC分类号： C07D401/14 , C07D213/75 , C07D213/40 , C07D405/12 , C07D413/12
CPC分类号： C07D213/53 , C07C275/30 , C07D213/40 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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公开(公告)号：US20130158034A1
公开(公告)日：2013-06-20
申请号：US13529880
申请日：2012-06-21
申请人： James BROWN , Jian J. CHEN , Vijay Keshav GORE , Scott HARRIED , Daniel B. Horne , Matthew R. KALLER , Qingyian LIU , Holger MONENSCHEIN , Thomas T. NGUYEN , Nobuko NISHIMURA , Wenge ZHONG
发明人： James BROWN , Jian J. CHEN , Vijay Keshav GORE , Scott HARRIED , Daniel B. Horne , Matthew R. KALLER , Qingyian LIU , Holger MONENSCHEIN , Thomas T. NGUYEN , Nobuko NISHIMURA , Wenge ZHONG
IPC分类号： C07D401/14 , C07D213/40 , C07D409/12 , C07D413/12 , C07D401/12 , C07D213/75 , C07D405/12
CPC分类号： C07D213/53 , C07C275/30 , C07D213/40 , C07D213/75 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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公开(公告)号：US20130157996A1
公开(公告)日：2013-06-20
申请号：US13529860
申请日：2012-06-21
申请人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
发明人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
IPC分类号： C07D498/04 , C07D401/14 , C07D213/81 , C07D487/04 , C07D413/12 , C07D401/12 , C07D471/04
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I的化合物可用作TRPM8的拮抗剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：US08710043B2
公开(公告)日：2014-04-29
申请号：US13529860
申请日：2012-06-21
申请人： Jian J. Chen , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma
发明人： Jian J. Chen , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma
IPC分类号： C07D498/04 , C07D401/12 , C07D471/04 , C07D213/81
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I的化合物可用作TRPM8的拮抗剂。 这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。 这些疾病的实例包括但不限于偏头痛和神经性疼痛。 式I的化合物具有以下结构：其中本文提供变量的定义。
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