公开(公告)号：US20130079325A1

公开(公告)日：2013-03-28

申请号：US13676826

申请日：2012-11-14

申请人： Jennifer R. Allen ,  Biswas Kaustav ,  Frank Chavez ,  Ning Chen ,  Frenel Fils De Morin ,  James R. Falsey ,  Michael J. Frohn ,  Paul E. Harrington ,  Daniel B. Horne ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Roxanne Kunz ,  Holger Monenschein ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Guomin Yao

发明人： Jennifer R. Allen ,  Biswas Kaustav ,  Frank Chavez ,  Ning Chen ,  Frenel Fils De Morin ,  James R. Falsey ,  Michael J. Frohn ,  Paul E. Harrington ,  Daniel B. Horne ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Roxanne Kunz ,  Holger Monenschein ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Guomin Yao

IPC分类号： C07D413/14 ,  C07D401/14 ,  C07D401/12

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00

摘要： Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。

公开(公告)号：US08497265B2

公开(公告)日：2013-07-30

申请号：US13106718

申请日：2011-05-12

申请人： Jennifer R. Allen ,  Daniel B. Horne ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Holger Monenschein ,  Thomas T. Nguyen ,  Andreas Reichelt ,  Robert M. Rzasa

发明人： Jennifer R. Allen ,  Daniel B. Horne ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Holger Monenschein ,  Thomas T. Nguyen ,  Andreas Reichelt ,  Robert M. Rzasa

IPC分类号： C07D241/18 ,  C07D413/14 ,  C07D401/14 ,  A61K31/5355 ,  A61K31/497 ,  A61P3/04 ,  A61P3/10 ,  A61P25/18

CPC分类号： C07D491/107 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/10

摘要： Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 杂环氧基杂环基化合物和含有它们的组合物，以及这些化合物的制备方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。

公开(公告)号：US08318718B2

公开(公告)日：2012-11-27

申请号：US12619573

申请日：2009-11-16

申请人： Jennifer R. Allen ,  Biswas Kaustav ,  Frank Chavez ,  Ning Chen ,  Frenel Fils De Morin ,  James R. Falsey ,  Michael J. Frohn ,  Paul E. Harrington ,  Daniel B. Horne ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Roxanne Kunz ,  Holger Monenschein ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Guomin Yao

发明人： Jennifer R. Allen ,  Biswas Kaustav ,  Frank Chavez ,  Ning Chen ,  Frenel Fils De Morin ,  James R. Falsey ,  Michael J. Frohn ,  Paul E. Harrington ,  Daniel B. Horne ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Roxanne Kunz ,  Holger Monenschein ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Guomin Yao

IPC分类号： A61K31/4439 ,  A61K31/437 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/397 ,  C07D401/12 ,  C07D471/04 ,  C07D473/00 ,  C07D413/14 ,  C07D401/14 ,  A61P25/00

CPC分类号： C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00

摘要： Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。

公开(公告)号：US20110306588A1

公开(公告)日：2011-12-15

申请号：US13106718

申请日：2011-05-12

申请人： Jennifer R. Allen ,  Daniel B. Horne ,  Essa Hu ,  Matthew R. Kaller ,  Holger Monenschein ,  Thomas T. Nguyen ,  Andreas Reichelt ,  Robert M. Rzasa

发明人： Jennifer R. Allen ,  Daniel B. Horne ,  Essa Hu ,  Matthew R. Kaller ,  Holger Monenschein ,  Thomas T. Nguyen ,  Andreas Reichelt ,  Robert M. Rzasa

IPC分类号： A61K31/497 ,  C07D413/14 ,  C07D491/107 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  A61K31/551 ,  A61K31/498 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P25/00 ,  A61P25/14 ,  A61P25/24 ,  A61P25/30 ,  C07D401/14

CPC分类号： C07D491/107 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/10

摘要： Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 杂环氧基杂环基化合物和含有它们的组合物，以及这些化合物的制备方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。

公开(公告)号：US08637500B2

公开(公告)日：2014-01-28

申请号：US12639931

申请日：2009-12-16

申请人： Jennifer R. Allen ,  Ning Chen ,  James R. Falsey ,  Michael J. Frohn ,  Paul E. Harrington ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Roxanne K. Kunz ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Aaron C. Siegmund ,  Guomin Yao

发明人： Jennifer R. Allen ,  Ning Chen ,  James R. Falsey ,  Michael J. Frohn ,  Paul E. Harrington ,  Essa Hu Harrington ,  Matthew R. Kaller ,  Roxanne K. Kunz ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Aaron C. Siegmund ,  Guomin Yao

IPC分类号： A61K31/551 ,  A61K31/553 ,  A61K31/5377 ,  A61K31/497 ,  C07D243/08 ,  C07D267/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14

CPC分类号： C07D401/04 ,  C07D213/74 ,  C07D213/84 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14

摘要： Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 吡啶和嘧啶化合物或其药学上可接受的盐，其中m，n，R1，R2，R3，R4，R5，R6，R7，X1，X2，X3，X4，X5，X6，X7，X8和Y为 如说明书中所定义; 或其药学上可接受的盐，其中环A，m，n，y，R2，R3，R4，R5，R6，R7，R8，R9，X1，X2和环A如说明书中所定义; 和其药学上可接受的盐，其中m，n，y，R2，R3，R4，R5，R6，R7，R9，X1，X2和环A如说明书中所定义; 含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。

公开(公告)号：US20100160280A1

公开(公告)日：2010-06-24

申请号：US12639931

申请日：2009-12-16

申请人： Jennifer R. Allen ,  Ning Chen ,  James R. Falsey ,  Michael Frohn ,  Paul Harrington ,  Essa Hu ,  Matthew R. Kaller ,  Roxanne Kunz ,  Stephanie J. Mercede ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Aaron C. Siegmund ,  Christopher M. Tegley ,  Guomin Yao

发明人： Jennifer R. Allen ,  Ning Chen ,  James R. Falsey ,  Michael Frohn ,  Paul Harrington ,  Essa Hu ,  Matthew R. Kaller ,  Roxanne Kunz ,  Stephanie J. Mercede ,  Thomas T. Nguyen ,  Alexander J. Pickrell ,  Andreas Reichelt ,  Shannon Rumfelt ,  Robert M. Rzasa ,  Kelvin Sham ,  Aaron C. Siegmund ,  Christopher M. Tegley ,  Guomin Yao

IPC分类号： A61K31/397 ,  C07D213/22 ,  A61K31/444 ,  C07D213/62 ,  C07D413/14 ,  A61K31/5377 ,  C07D401/02 ,  A61K31/506 ,  C07D403/14 ,  A61K31/4545 ,  A61K31/496 ,  C07D267/10 ,  A61K31/553 ,  C07D243/08 ,  A61K31/551 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D213/74 ,  C07D213/84 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14

摘要： Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 吡啶和嘧啶化合物或其药学上可接受的盐，其中m，n，R1，R2，R3，R4，R5，R6，R7，X1，X2，X3，X4，X5，X6，X7，X8和Y为 如说明书中所定义; 或其药学上可接受的盐，其中环A，m，n，y，R2，R3，R4，R5，R6，R7，R8，R9，X1，X2和环A如说明书中所定义; 和其药学上可接受的盐，其中m，n，y，R2，R3，R4，R5，R6，R7，R9，X1，X2和环A如说明书中所定义; 含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖型糖尿病，精神分裂症，双相情感障碍，强迫症等。

公开(公告)号：US08193199B2

公开(公告)日：2012-06-05

申请号：US12079406

申请日：2008-03-24

申请人： Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

发明人： Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P35/00 ,  A61P19/02 ,  A61P37/06 ,  A61P19/08 ,  C07D487/04 ,  C07D241/40 ,  C07D241/44 ,  C07D215/14 ,  C07D215/26 ,  C07D215/22 ,  C07D417/14 ,  C07D417/04

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D473/34

摘要： Substituted bicyclic heteroaryls having the structures: and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 具有以下结构的取代的双环杂芳基：和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎症 包括但不限于自身免疫疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性疾病， 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） Ch 骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

公开(公告)号：US20090030002A1

公开(公告)日：2009-01-29

申请号：US12079281

申请日：2008-03-24

申请人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

发明人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC分类号： A61K31/498 ,  C07D473/34 ,  A61K31/52 ,  C07D471/02 ,  A61P29/00 ,  A61P19/02 ,  A61P37/02 ,  A61P35/00 ,  A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelodysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，例如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（Myeloid Leukemi）的介导，依赖或与p110delta活性相关的癌症的方法 （CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

公开(公告)号：US08946230B2

公开(公告)日：2015-02-03

申请号：US13103858

申请日：2011-05-09

申请人： Jennifer R. Allen ,  Kristin L. Andrews ,  Michael J. Frohn ,  Paul E. Harrington ,  Alexander J. Pickrell ,  Robert M. Rzasa

发明人： Jennifer R. Allen ,  Kristin L. Andrews ,  Michael J. Frohn ,  Paul E. Harrington ,  Alexander J. Pickrell ,  Robert M. Rzasa

IPC分类号： A61K31/497 ,  A61K31/506 ,  A61K31/4709 ,  C07D471/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14

摘要： Aryl- and heteroaryl-nitrogen heterocyclic compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein m, p, q, R1, R2, R3, X1, X2, X3, Y1 and Y2 are defined herein; and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.

摘要翻译： 式（I）的芳基和杂芳基氮杂环化合物或其药学上可接受的盐，其中m，p，q，R1，R2，R3，X1，X2，X3，Y1和Y2如本文所定义; 和含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，亨廷顿舞蹈病，双相情感障碍，强迫症等。

公开(公告)号：US20100179177A1

公开(公告)日：2010-07-15

申请号：US12713360

申请日：2010-02-26

申请人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

发明人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC分类号： A61K31/506 ,  C07D239/42 ,  C07D215/36 ,  A61K31/4709 ,  C07D215/12 ,  A61P19/02 ,  A61P19/00 ,  A61P29/00 ,  A61P37/00 ,  A61P27/02 ,  A61P13/10 ,  A61P17/00 ,  A61P1/00 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D401/14

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD），介导，依赖或与p110δ活性相关的癌症的方法 （CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。