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公开(公告)号：US20140309190A1
公开(公告)日：2014-10-16
申请号：US14306231
申请日：2014-06-17
申请人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Ma Bin , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Ma Bin , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： A61K31/695 , A61K31/11 , A61K31/18 , A61K31/216 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/683 , A61K31/662 , A61K31/47 , A61K31/277 , A61K31/41 , A61K31/4709 , A61K31/472 , A61K31/337 , A61K31/517 , A61K31/428 , A61K31/404 , A61K45/06 , C07C43/247 , C07C47/575 , C07C311/51 , C07C229/14 , C07D205/04 , C07D207/16 , C07D211/62 , C07F9/40 , C07D215/227 , C07C255/54 , C07D257/04 , C07F7/08 , C07D401/06 , C07D217/04 , C07D305/08 , C07D239/74 , C07D277/64 , C07D209/08 , C07F9/38 , A61K31/085
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是肌氨酸 - 甙类似物，磷酸化后，可以作为S1P受体的激动剂。
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公开(公告)号：US08269043B2
公开(公告)日：2012-09-18
申请号：US12588883
申请日：2009-10-30
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： C07C211/00 , C09B11/02 , A61K31/66
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US20120190649A1
公开(公告)日：2012-07-26
申请号：US13389054
申请日：2010-08-05
申请人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： A61K31/683 , C07C47/575 , C07C311/51 , C07C229/36 , C07D205/04 , C07D207/16 , C07D211/62 , C07D215/227 , C07D239/74 , C07D403/06 , A61K31/085 , A61K31/11 , A61K31/21 , A61K31/216 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/47 , A61K31/517 , A61K31/662 , A61P25/00 , A61P37/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P1/00 , A61P3/10 , A61K31/56 , A61P11/08 , A61P37/06 , A61P37/02 , C07C43/247
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US20100160258A1
公开(公告)日：2010-06-24
申请号：US12588883
申请日：2009-10-30
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： A61K31/66 , C12Q1/48 , A61K31/135 , C07F9/06 , C07C223/02
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US08802659B2
公开(公告)日：2014-08-12
申请号：US13389054
申请日：2010-08-05
申请人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： C07C43/00 , C07C47/575 , C07C229/36 , C07C311/51 , C07D205/04 , C07D207/16 , C07D211/62 , C07D215/227 , C07D239/74 , C07D403/06
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US08546359B2
公开(公告)日：2013-10-01
申请号：US13608227
申请日：2012-09-10
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： A01N57/00 , C07C211/00
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.
摘要翻译： 提供了在一种或多种SIP受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为SIP受体的激动剂。
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公开(公告)号：US20130059821A1
公开(公告)日：2013-03-07
申请号：US13608227
申请日：2012-09-10
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： A61K31/137 , A61K31/421 , A61K31/337 , A61K31/505 , A61K31/56 , A61P25/00 , A61P37/00 , A61P3/10 , A61P19/02 , A61P1/00 , A61P17/06 , A61K31/661 , A61P29/00
CPC分类号： A61K31/135 , A61K31/27 , C07C205/26 , C07C205/50 , C07C217/52 , C07C217/60 , C07C229/32 , C07C271/16 , C07D263/38 , C07F9/091 , C07F9/093 , C07F9/653 , C07F9/65744
摘要： Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.
摘要翻译： 提供了在一种或多种SIP受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为SIP受体的激动剂。
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公开(公告)号：US08349849B2
公开(公告)日：2013-01-08
申请号：US12588882
申请日：2009-10-30
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： A61K31/517
CPC分类号： A61K31/135 , A61K31/22 , C07C217/52 , C07C217/74 , C07C2602/10 , C07D215/20 , C07D239/74
摘要： Compounds of formula (I): that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供式（I）化合物：在一种或多种S1P受体上具有激动剂活性。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US20100160357A1
公开(公告)日：2010-06-24
申请号：US12588882
申请日：2009-10-30
申请人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
发明人： Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC分类号： A61K31/517 , G01N33/53 , A61K31/47 , A61K31/421 , C07D239/74 , C07D215/14 , C07D215/20 , C07D263/24 , A61P25/00 , A61P37/00 , A61P1/00 , A61P11/06
CPC分类号： A61K31/135 , A61K31/22 , C07C217/52 , C07C217/74 , C07C2602/10 , C07D215/20 , C07D239/74
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译： 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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