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公开(公告)号：US20240076598A1
公开(公告)日：2024-03-07
申请号：US18243829
申请日：2023-09-08
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
CPC classification number: C12M27/04 , C12M23/28 , C12M23/38 , C12M29/06 , B01F23/233 , B01F27/91 , B01F35/146 , B01F35/514
Abstract: Miniature stirred tank bioreactor and system; the bioreactor configured for single use culturing, providing unobstructed culturing volume with sensors, probes and ports using minimally invasive placement in-wall or across the wall methods; the bioreactor further capable of containing scaffolds and features for culturing cells and tissue, including structures providing surfaces for cell growth, and screens for retaining microparticles during media exchange
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公开(公告)号：US20200165558A1
公开(公告)日：2020-05-28
申请号：US16612460
申请日：2018-05-10
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
Abstract: Miniature stirred tank bioreactor and system; the bioreactor configured for single use culturing providing unobstructed culturing volume with sensors, probes and ports using minimally invasive placement in-wall or across the wall methods; the bioreactor further capable of containing scaffolds and features for culturing cells and tissue, including structures providing surfaces for cell growth, and screens for retaining microparticles during media exchange.
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公开(公告)号：US20190167971A1
公开(公告)日：2019-06-06
申请号：US16305798
申请日：2017-05-30
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
Abstract: A connector for facilitating the connection of one piece of tubing to another so that fluid can flow from one piece to the other in a sterile manner. Characteristics of the connector include, hut are not limited to, a flange at one of the connector, the flange comprising a recess for storage of at least part of a protective shield which Is removable after the flange is connected to the flange of a second connector.
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公开(公告)号：US20130270165A1
公开(公告)日：2013-10-17
申请号：US13818679
申请日：2011-08-24
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
IPC: B01D61/58
CPC classification number: B01D61/58 , B01D63/02 , B01D2313/13 , B01D2313/243 , C12M23/40 , C12M29/00 , C12M29/04 , C12M29/10 , C12M33/00 , C12M41/26 , C12M41/32 , C12M41/38 , C12M41/40 , C12M47/10
Abstract: Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump. Also dual diaphragm pump, a diaphragm pump-driven sampling manifold, and a modifier module, all usable with the enclosed reactor systems as well as other systems.
Abstract translation: 封闭的反应器系统，每个至少三个室，在由选择性渗透屏障控制的室之间的流体流动，由交流流动隔膜泵控制。 还有双隔膜泵，隔膜泵驱动的取样歧管和修改器模块，都可用于封闭的反应器系统以及其他系统。
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公开(公告)号：US5635603A
公开(公告)日：1997-06-03
申请号：US352715
申请日：1994-12-05
Applicant: Hans J. Hansen , Shui-on Leung , Jerry Shevitz , Gary L. Griffiths , Seregulam V. Govindan
Inventor： Hans J. Hansen , Shui-on Leung , Jerry Shevitz , Gary L. Griffiths , Seregulam V. Govindan
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61K49/00 , A61K51/10 , C07H21/04 , C07K16/00 , C07K16/30 , C07K17/00 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/532 , G01N33/563 , G01N33/68
CPC classification number: G01N33/6857 , A61K51/1048 , A61K51/1069 , A61K51/1093 , C07K16/00 , C07K16/30 , C07K16/3007 , C07K16/3061 , G01N33/532 , A61K2121/00 , A61K2123/00 , A61K38/00
Abstract: The present invention relates to immunoconjugates comprising an antibody fragment which is covalently bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an antibody moiety that is an intact antibody containing a glycosylation site in the light chain variable domain which has been introduced into the antibody by mutating the nucleotide sequence encoding the light chain. The resultant immunoconjugates retain the immunoreactivity of the antibody fragment or intact antibody, and target the diagnostic or therapeutic principle to a target tissue where the diagnostic or therapeutic effect is realized. Thus, the invention contemplates the use of such immunoconjugates for diagnosis and immunotherapy. The invention further relates to methods for preparing such immunoconjugates.
Abstract translation: 本发明涉及包含通过抗体片段的轻链可变区中的碳水化合物部分与诊断或治疗原理共价结合的抗体片段的免疫缀合物。 本发明还涉及包含抗体部分的免疫缀合物，所述抗体部分是通过突变编码轻链的核苷酸序列而被引入抗体的包含轻链可变结构域中的糖基化位点的完整抗体。 所得的免疫偶联物保留抗体片段或完整抗体的免疫反应性，并将诊断或治疗原理靶向实现诊断或治疗效果的靶组织。 因此，本发明考虑使用这种免疫缀合物进行诊断和免疫治疗。 本发明还涉及制备这种免疫缀合物的方法。
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Patent Agency Ranking
公开(公告)号：US5443953A
公开(公告)日：1995-08-22
申请号：US162912
申请日：1993-12-08
Applicant: Hans J. Hansen , Shui-on Leung , Jerry Shevitz
Inventor： Hans J. Hansen , Shui-on Leung , Jerry Shevitz
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61K49/00 , A61K51/10 , C07H21/04 , C07K16/00 , C07K16/30 , C07K17/00 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/532 , G01N33/563 , G01N33/68
CPC classification number: G01N33/6857 , A61K51/1048 , A61K51/1069 , A61K51/1093 , C07K16/00 , C07K16/30 , C07K16/3007 , C07K16/3061 , G01N33/532 , A61K2121/00 , A61K2123/00 , A61K38/00
Abstract: The present invention relates to immunoconjugates comprising an antibody fragment which is covalently bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an antibody moiety that is an intact antibody containing a glycosylation site in the light chain variable domain which has been introduced into the antibody by mutating the nucleotide sequence encoding the light chain. The resultant immunoconjugates retain the immunoreactivity of the antibody fragment or intact antibody, and target the diagnostic or therapeutic principle to a target tissue where the diagnostic or therapeutic effect is realized. Thus, the invention contemplates the use of such immunoconjugates for diagnosis and immunotherapy. The invention further relates to methods for preparing such immunoconjugates.
Abstract translation: 本发明涉及包含通过抗体片段的轻链可变区中的碳水化合物部分与诊断或治疗原理共价结合的抗体片段的免疫缀合物。 本发明还涉及包含抗体部分的免疫缀合物，所述抗体部分是通过突变编码轻链的核苷酸序列而被引入抗体的包含轻链可变结构域中的糖基化位点的完整抗体。 所得的免疫偶联物保留抗体片段或完整抗体的免疫反应性，并将诊断或治疗原理靶向实现诊断或治疗效果的靶组织。 因此，本发明考虑使用这种免疫缀合物进行诊断和免疫治疗。 本发明还涉及制备这种免疫缀合物的方法。
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7.发明授权Device, system and process for modification or concentration of cell-depleted fluid 有权用于改变或浓缩细胞贫乏液体的装置，系统和方法公开(公告)号：US09446354B2
公开(公告)日：2016-09-20
申请号：US13408243
申请日：2012-02-29
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
CPC classification number: C12M29/18 , B01D61/14 , B01D61/58 , B01D63/02 , B01D2313/13 , B01D2313/243 , B01D2313/50 , C12M29/04 , C12M29/16 , C12M33/10
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
Abstract translation: 一种产品浓度装置，其利用连接到中空纤维过滤元件的储存器，其中储存器可以用作从另一个过滤装置发出的滤液的容器，使得储存器中的产品可以根据需要进行储存，浓缩和/或进一步处理 。 封闭的反应器系统，每个至少三个室，在由选择性渗透屏障控制的室之间的流体流动，由交流流动隔膜泵控制。
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8.发明申请Device, System and Process for Modification or Concentration of Cell-depleted Fluid 有权用于改变或浓缩细胞消耗液体的装置，系统和方法公开(公告)号：US20130059371A1
公开(公告)日：2013-03-07
申请号：US13408243
申请日：2012-02-29
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
CPC classification number: C12M29/18 , B01D61/14 , B01D61/58 , B01D63/02 , B01D2313/13 , B01D2313/243 , B01D2313/50 , C12M29/04 , C12M29/16 , C12M33/10
Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
Abstract translation: 一种产品浓度装置，其利用连接到中空纤维过滤元件的储存器，其中储存器可以用作从另一个过滤装置发出的滤液的容器，使得储存器中的产品可以根据需要进行储存，浓缩和/或进一步处理 。 封闭的反应器系统，每个至少三个室，在由选择性渗透屏障控制的室之间的流体流动，由交流流动隔膜泵控制。
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公开(公告)号：US20100078395A1
公开(公告)日：2010-04-01
申请号：US12565605
申请日：2009-09-23
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
CPC classification number: B01D29/68 , B01D29/111 , B01D29/114 , B01D29/13 , B01D29/66 , B01D35/153 , B01D35/26 , B01D35/30 , C12M47/02
Abstract: Improved screen filter modules, related compartmentalized filtration modules, and related filtration processes, suitable for filtering fluid to eliminate suspended particulate matter, such as living cells or microcarriers anchoring living cells, or to separate particulate matter based on size. The improvement is the presence of a barrier that channels redirected filtrate to the portion of the filter most susceptible to clogging by the particulate matter and induces flow patterns that act against clogging.
Abstract translation: 改进的筛网过滤器模块，相关的分区过滤模块和相关的过滤方法，适用于过滤流体以消除悬浮颗粒物质，例如锚定活细胞的活细胞或微载体，或基于尺寸分离颗粒物质。 改进是存在通道将滤液重新导向过滤器的部分，其最容易受到颗粒物质的堵塞并且引起阻止堵塞的流动模式。
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公开(公告)号：US11773361B2
公开(公告)日：2023-10-03
申请号：US16612460
申请日：2018-05-10
Applicant: Jerry Shevitz
Inventor： Jerry Shevitz
CPC classification number: C12M27/04 , B01F23/233 , B01F27/91 , B01F35/146 , B01F35/514 , C12M23/28 , C12M23/38 , C12M29/06
Abstract: Miniature stirred tank bioreactor and system; the bioreactor configured for single use culturing providing unobstructed culturing volume with sensors, probes and ports using minimally invasive placement in-wall or across the wall methods; the bioreactor further capable of containing scaffolds and features for culturing cells and tissue, including structures providing surfaces for cell growth, and screens for retaining microparticles during media exchange.
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