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公开(公告)号：US09238680B2
公开(公告)日：2016-01-19
申请号：US13140779
申请日：2009-12-21
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C07K14/415 , C12N15/8279
摘要： Disclosed are nucleic acid molecules which encode heat-stable plant resistance polypeptides having NB-LRR structural motifs, where the polypeptide confers heat-stability to a plant defense response. The invention further involves transgenic plants and transformed host cells that express these nucleic acid molecules and exhibit enhanced disease resistance over a wide range of temperatures.
摘要翻译： 公开了编码具有NB-LRR结构基序的热稳定植物抗性多肽的核酸分子，其中多肽赋予植物防御反应的热稳定性。 本发明还涉及表达这些核酸分子的转基因植物和转化的宿主细胞，并且在宽的温度范围内表现出增强的抗病性。
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公开(公告)号：US20120030835A1
公开(公告)日：2012-02-02
申请号：US13140779
申请日：2009-12-21
CPC分类号： C07K14/415 , C12N15/8279
摘要： Disclosed are nucleic acid molecules which encode heat-stable plant resistance polypeptides having NB-LRR structural motifs, where the LRR domain includes a sub-domain which confers heat-stability to a plant defense response. The invention further involves transgenic plants and transformed host cells that express these nucleic acid molecules and exhibit enhanced disease resistance over a wide range of temperatures.
摘要翻译： 公开了编码具有NB-LRR结构基序的热稳定植物抗性多肽的核酸分子，其中LRR结构域包括赋予植物防御反应热稳定性的亚结构域。 本发明还涉及表达这些核酸分子的转基因植物和转化的宿主细胞，并且在宽的温度范围内表现出增强的抗病性。
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公开(公告)号：US20140044857A1
公开(公告)日：2014-02-13
申请号：US14002539
申请日：2011-03-02
申请人： Jian Hua , Xinghui Chang
发明人： Jian Hua , Xinghui Chang
IPC分类号： A24D1/00
CPC分类号： A24D1/002 , A24B15/281 , A24B15/30
摘要： A method for preparing water-soluble tobacco flavor in gel state is disclosed. The method includes the following steps: mixing food thickener with glycerol in a mass ratio of 1:50 to 1:5 and mixing to uniform, heating to a temperature of 80° C. to 100 ° C. and keep stirring till dissolve thoroughly, homogenizing for 5 to 15 minutes, cooling to a temperature of 30° C. to 50° C., adding water-soluble tobacco flavor and mixing to uniform, and placing at least 12 hours at a temperature of 1° C. to 30 ° C. to obtain a final product. The product obtained by the method can greatly inhibit volatilization of the tobacco flavor, maintain fragrance completely, reduce the loss caused by volatile components, and can be easily transported and stored.
摘要翻译： 公开了一种制备凝胶态水溶性烟草香精的方法。 该方法包括以下步骤：将食品增稠剂与甘油以1:50至1:5的质量比混合并均匀混合，加热至80℃至100℃，继续搅拌直至彻底溶解， 均化5至15分钟，冷却至30℃至50℃的温度，加入水溶性烟草香料并混合均匀，并在1℃至30℃的温度下放置至少12小时 C.获得最终产品。 通过该方法获得的产品可以极大地抑制烟草香味的挥发，完全保持香味，减少由挥发性成分引起的损失，并且可以方便的运输和储存。
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公开(公告)号：US11752277B2
公开(公告)日：2023-09-12
申请号：US15733525
申请日：2019-03-13
申请人： Jian Hua
发明人： Jian Hua , Xuefeng Song
CPC分类号： A61M11/00 , A61M16/00 , A61M16/06 , A61M39/08 , A61M2016/003 , A61M2016/0027 , A61M2205/3331 , A61M2205/3334 , A61M2205/3584 , A61M2205/505 , A61M2205/587 , A61M2205/8206 , A61M2209/08
摘要： A nebulization device having dual modules includes: a nebulization host machine; a three-way tube communicated with the nebulization host machine; and a controller connected to the nebulization host machine; the nebulization host machine further includes a side cover, a nozzle arranged on a lower side of the side cover, a liquid medicine bottle arranged on an upper side of the side cover and communicated with the nozzle, a nebulization sheet arranged on one side of the liquid medicine bottle and communicated with the nozzle, and a first plug-in interface arranged below the liquid medicine bottle; a bottom portion within an interior of the nozzle is provided with a partition plate that divides the interior of the nozzle into an upper nebulization chamber and a lower gas flow chamber.
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公开(公告)号：US20070048861A1
公开(公告)日：2007-03-01
申请号：US11333770
申请日：2006-01-17
申请人： Harriet Robinson , James Smith , Jian Hua , Bernard Moss , Rama Amara , Linda Wyatt , Patricia Earl , Ted Ross , Rick Bright , Salvatore Butera , Dennis Ellenberger , Thomas Folks
发明人： Harriet Robinson , James Smith , Jian Hua , Bernard Moss , Rama Amara , Linda Wyatt , Patricia Earl , Ted Ross , Rick Bright , Salvatore Butera , Dennis Ellenberger , Thomas Folks
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/70 , C07K14/005 , C07K14/472 , C07K16/10 , C07K2319/00 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/85 , C12N15/86 , C12N2710/24134 , C12N2710/24143 , C12N2740/16043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16334 , C12N2760/16134 , C12N2830/42 , C12N2840/107 , C12N2840/20
摘要： The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.
摘要翻译： 本发明涉及用于递送DNA疫苗的新型质粒构建体。 本发明提供具有转录盒的新颖质粒，其能够引导编码来自任何病原体（包括真菌，细菌和病毒）的免疫原的疫苗核酸插入物的表达。 然而，本发明特别可用于在患者中诱导针对病毒性病毒如HIV，麻疹或流行性感冒的免疫应答。 本发明的免疫缺陷病毒疫苗插入物表达具有多个病毒表位的非传染性HIV病毒样颗粒（VLP）。 VLP允许将表位呈现给多种组织相容性类型，从而降低靶向病毒逃避免疫应答的可能性。 还描述了通过将本发明的新型质粒递送给患者以在其中表达疫苗插入物来免疫患者的方法。 任选地，免疫方案可以包括加强免疫接种，其可以是活载体疫苗，例如重组痘病毒或修饰的牛痘Arbora载体。 增效活疫苗载体包括表达与初次免疫载体相同疫苗插入片段的转录盒。
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公开(公告)号：US20050284623A1
公开(公告)日：2005-12-29
申请号：US10876242
申请日：2004-06-24
申请人： Wallace Poole , James Abbott , Gabriel Kuschel , Jian Hua
发明人： Wallace Poole , James Abbott , Gabriel Kuschel , Jian Hua
CPC分类号： F01N5/02 , F01N1/006 , F01N2470/02 , F01N2490/08 , F01N2490/14 , F01N2490/155 , F28D7/024 , F28F2265/28 , Y02T10/16
摘要： A combined muffler and heat exchanger apparatus is provided. The apparatus includes a housing defining a heat transfer chamber and an acoustic attenuation chamber separated by a partition. A flow regulator and a fluid transport member are disposed within the heat transfer chamber. The flow regulator is adapted to regulate the flow of a first fluid, such as a heat source, between an input end of the housing and the partition. The fluid transport member is adapted to contain the flow of a second fluid. An acoustic regulator is disposed in the acoustic attenuation chamber and extends longitudinally from the partition to an output end of the housing. The acoustic regulator is a metal tube including a plurality of apertures adapted to attenuate exhaust stream acoustics associated with an automotive vehicle power source.
摘要翻译： 提供了组合的消音器和热交换器装置。 该装置包括限定传热室的壳体和由隔板分隔开的声衰减室。 流量调节器和流体输送构件设置在传热室内。 流量调节器适于调节壳体的输入端和隔板之间的第一流体（例如热源）的流动。 流体输送构件适于容纳第二流体的流动。 声调节器设置在声衰减室中并且从隔板纵向延伸到壳体的输出端。 声调节器是包括适于衰减与汽车动力源相关联的排气流声学的多个孔的金属管。
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9.发明申请PROVIDING A MEETING LINK TO A PARTICIPANT WHO HAS LEFT A LOCATION OF THE MEETING 审中-公开向与会者提供与会者的会议连接，会议地点不在位公开(公告)号：US20160205154A1
公开(公告)日：2016-07-14
申请号：US14592093
申请日：2015-01-08
申请人： Haihua Huang , Yuan Wu , Dapeng Sun , Qiulan Huang , Jian Hua
发明人： Haihua Huang , Yuan Wu , Dapeng Sun , Qiulan Huang , Jian Hua
CPC分类号： H04L65/403 , G06F16/9558 , H04N7/15 , H04N2007/145 , H04W4/02
摘要： In one embodiment, a method includes identifying a first device as being located at a first physical location associated with a meeting, and determining when the first device is no longer located at the first physical location during the meeting. When it is determined that the first device is no longer located at the first physical location during the meeting, the method also includes determining whether to provide a meeting link to the first device, the meeting link being arranged to allow the first device to join the meeting. Finally, the method includes providing the meeting link to the first device if it is determined that the meeting link is to be provided to the first device.
摘要翻译： 在一个实施例中，一种方法包括将第一设备识别为位于与会议相关联的第一物理位置处，以及确定在会议期间何时第一设备不再位于第一物理位置。 当在会议期间确定第一设备不再位于第一物理位置时，该方法还包括确定是否向第一设备提供会议链接，会议链路被布置为允许第一设备加入 会议。 最后，如果确定将会议链路提供给第一设备，该方法包括向第一设备提供会议链路。
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公开(公告)号：US20150231227A1
公开(公告)日：2015-08-20
申请号：US12749164
申请日：2010-03-29
申请人： Harriet L. Robinson , James M. Smith , Jian Hua , Bernard Moss , Rama R. Amara , Linda S. Wyatt , Patricia L. Earl , Ted M. Ross , Rick A. Bright , Salvatore T. Butera , Dennis L. Ellenberger , Thomas M. Folks
发明人： Harriet L. Robinson , James M. Smith , Jian Hua , Bernard Moss , Rama R. Amara , Linda S. Wyatt , Patricia L. Earl , Ted M. Ross , Rick A. Bright , Salvatore T. Butera , Dennis L. Ellenberger , Thomas M. Folks
IPC分类号： A61K39/21 , A61K39/145 , C12N7/00 , A61K39/165
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N2710/24134 , C12N2710/24143 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2760/16134
摘要： Novel plasmid constructs useful for the delivery of DNA vaccines are provided having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The constructs are useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to a patient. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector having a transcription cassette expressing the same vaccine insert as the primary immunizing vector.
摘要翻译： 提供了可用于递送DNA疫苗的新型质粒构建体，其具有能够指导编码来自任何病原体（包括真菌，细菌和病毒）的免疫原的疫苗核酸插入物的表达的转录盒。 所述构建体可用于在患者中诱导针对病原体病毒如HIV，麻疹或流行性感冒的免疫应答。 本发明的免疫缺陷病毒疫苗插入物表达具有多个病毒表位的非传染性HIV病毒样颗粒（VLP）。 VLP允许将表位呈现给多种组织相容性类型。 还描述了通过将本发明的新型质粒递送给患者来免疫患者的方法。 任选地，免疫方案可以包括加强免疫接种，其可以是活载体疫苗例如重组痘病毒或具有表达与主免疫载体相同的疫苗插入片段的转录盒的修饰的痘苗痘苗载体。
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