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    Hybrid-ionone and curcumin molecules as anticancer agents
    1.
    发明授权
    Hybrid-ionone and curcumin molecules as anticancer agents 有权
    杂合紫罗兰酮和姜黄素分子作为抗癌剂

    公开(公告)号：US08470889B2

    公开(公告)日：2013-06-25

    申请号：US13131275

    申请日：2009-11-25

    申请人： Jian Hui Wu ,  Gérald Batist ,  Jinming Zhou ,  Guoyan Geng ,  Rongtuan Lin ,  Yi Li

    发明人： Jian Hui Wu ,  Gérald Batist ,  Jinming Zhou ,  Guoyan Geng ,  Rongtuan Lin ,  Yi Li

    IPC分类号： C07C49/14

    CPC分类号： C07D209/86 ,  C07C49/252 ,  C07D213/64 ,  C07D215/14 ,  C07D231/12 ,  C07D239/26 ,  C07D303/32 ,  C07D403/04 ,  C07D409/04

    摘要： The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.

    摘要翻译： 本发明涉及一系列紫罗酮和姜黄素衍生物的合成，所述紫罗酮和姜黄素衍生物作为有效对抗激素敏感和激素非依赖性癌症的多靶向剂。 特别地，本发明涉及一种不同种类的双功能抗雄激素，其抑制AR和IκB激酶（IKK）。 合成了一系列基于紫罗烯酮的查尔酮，证明了其对前列腺癌细胞系的体外细胞毒性。 通过使基于紫罗酮的查尔酮和肼反应形成的一系列衍生物在前列腺癌，乳腺癌和肺癌细胞系中表现出显着的抗增殖活性。

    Knowledge-based entity detection and disambiguation
    3.
    发明授权
    Knowledge-based entity detection and disambiguation 有权

    公开(公告)号：US09665643B2

    公开(公告)日：2017-05-30

    申请号：US13340722

    申请日：2011-12-30

    申请人： Kang Li ,  Yi Li ,  Yiping Zhou ,  Zhengdong Lv ,  Yohn Cao

    发明人： Kang Li ,  Yi Li ,  Yiping Zhou ,  Zhengdong Lv ,  Yohn Cao

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30867 ,  G06F17/30687 ,  G06F17/30864

    摘要： An entity-based search system is described herein that detects and recognizes entities in Internet-based content and uses this recognition to organize search results. The system associates one or more entity identifiers with a web page and stores this information as metadata of the page in a search engine index. This metadata will enable entity-based queries as well as rich data presentations in a search engine result page (SERP), including grouping results by entities, filtering results by one or more particular entities, or re-ranking search results based on user preference of entities. Thus, the entity-based search system allows users to identify a particular entity the user is interested in finding, and to receive search results directly related to that entity.

    Projection system using excitable wavelength conversion material in the light source
    4.
    发明授权
    Projection system using excitable wavelength conversion material in the light source 有权

    公开(公告)号：US09612511B2

    公开(公告)日：2017-04-04

    申请号：US13594187

    申请日：2012-08-24

    申请人： Fei Hu ,  Yi Li ,  Yi Yang

    发明人： Fei Hu ,  Yi Li ,  Yi Yang

    IPC分类号： G03B21/20 ,  G03B33/06

    CPC分类号： G03B21/204 ,  G03B33/06

    摘要： A solid state light source device for generating a constant broad band light useful in multiple SLM projectors. The light source device includes a blue or UV/near UV excitation light and a moving plate carrying wavelength conversion materials to convert the excitation light into a broad band light. The wavelength conversion materials include red, green, yellow and/or blue phosphors, and may pass some of the blue excitation light. The broad band light outputted by the phosphor plate includes at least two primary color components and has a constant intensity and spectrum as a function of time. The solid state light source device further includes a second light source such as a blue light source, and a light combination device which combines the output light of the moving phosphor plate and the light from the second light source into one beam of constant, broad band light.

    Light source system and projection system applied thereby
    5.
    发明授权
    Light source system and projection system applied thereby 有权
    因此应用光源系统和投影系统

    公开(公告)号：US09500345B2

    公开(公告)日：2016-11-22

    申请号：US14346300

    申请日：2012-08-10

    申请人： Yi Yang ,  Yi Li

    发明人： Yi Yang ,  Yi Li

    IPC分类号： F21V17/02 ,  G03B21/20 ,  F21V9/16 ,  F21V13/02 ,  F21V13/08 ,  G01J1/04 ,  G03B21/16

    CPC分类号： F21V17/02 ,  F21V9/30 ,  F21V13/02 ,  F21V13/08 ,  G01J1/0448 ,  G03B21/16 ,  G03B21/204 ,  G03B21/2093

    摘要： A light source system and a projection system employing the same. The light source system includes a light source emitting an excitation light, a moving device carrying a wavelength conversion material and an adjustment device. The excitation light irradiates on the wavelength conversion material. When the moving device is in a periodical moving state, the light spot position irradiated by the excitation light on the moving device moves following a first working track. The adjustment device is used for adjusting the light spot position irradiated by the adjusted excitation light on the moving device so that it moves following a second working track. The first working track is separated from the second working track. The system can reduce the working load of the wavelength conversion material on the first working track, thus slowing the aging of the wavelength conversion material, and improving the life of the light source system.

    摘要翻译： 光源系统和采用该光源系统的投影系统。 光源系统包括发射激发光的光源，携带波长转换材料的移动装置和调节装置。 激发光照射在波长转换材料上。 当移动装置处于周期性移动状态时，由移动装置上的激发光照射的光点位置在第一工作轨迹之后移动。 调整装置用于调整由移动装置上调节的激发光照射的光点位置，使其在第二工作轨迹之后移动。 第一个工作轨道与第二个工作轨道分开。 该系统可以降低第一工作轨道上的波长转换材料的工作负荷，从而减慢波长转换材料的老化，并提高光源系统的使用寿命。

    Light source, control method for light source, and projection system having light source
    9.
    发明授权
    Light source, control method for light source, and projection system having light source 有权
    光源，光源控制方法和具有光源的投影系统

    公开(公告)号：US09088731B2

    公开(公告)日：2015-07-21

    申请号：US13263286

    申请日：2010-04-07

    申请人： Yi Li ,  Quanquan Chen

    发明人： Yi Li ,  Quanquan Chen

    IPC分类号： G03B21/20 ,  H04N9/31

    CPC分类号： H04N9/3114 ,  G03B21/204 ,  H04N9/3111 ,  H04N9/3164

    摘要： A light source includes a first light emitting source (2), a second light emitting source (3), a color-adjusting apparatus (1) with light wavelength conversion material, a control unit, and a positioning apparatus provided on the color-adjusting apparatus (1). The positioning apparatus sends a positioning signal which indicates a position of the color-adjusting apparatus to the control unit. The control unit outputs a control signal to the power switch of the second light emitting source so that the second light emitting source is controlled to stop emitting the light when the light generated by the color-adjusting apparatus is the same as that of the first light emitting source. A control method for light source and a projection system having light source are also disclosed.

    摘要翻译： 光源包括第一发光源（2），第二发光源（3），具有光波长转换材料的调色设备（1），控制单元和设置在调色板上的定位设备 装置（1）。 定位装置将指示调色装置的位置的定位信号发送到控制单元。 控制单元向第二发光源的电源开关输出控制信号，使得当由颜色调节装置产生的光与第一光的相同时，第二发光源被控制为停止发光 发射源。 还公开了一种用于光源的控制方法和具有光源的投影系统。